miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling

FEBS Journal ◽  
2013 ◽  
Vol 280 (18) ◽  
pp. 4531-4538 ◽  
Author(s):  
Yuwen Guo ◽  
Liang Ying ◽  
Ye Tian ◽  
Peiqian Yang ◽  
Yichen Zhu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Wnt Signaling ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cancer Cell Proliferation

scholarly journals lncRNA CCAT1 promotes bladder cancer cell proliferation, migration and invasion

2019 ◽  
Vol 45 (3) ◽  
pp. 549-559 ◽  
Author(s):  
Caixiang Zhang ◽  
Wenying Wang ◽  
Jun Lin ◽  
Jing Xiao ◽  
Ye Tian
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation

scholarly journals ADNP Upregulation Promotes Bladder Cancer Cell Proliferation via the AKT Pathway

2020 ◽  
Vol 10 ◽  
Author(s):  
Shuai Zhu ◽  
Zhenzhou Xu ◽  
Yong Zeng ◽  
Ying Long ◽  
Gang Fan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Akt Pathway ◽  
Cancer Cell Proliferation

scholarly journals miR-143 inhibits bladder cancer cell proliferation and enhances their sensitivity to gemcitabine by repressing IGF-1R signaling

2016 ◽  
Vol 13 (1) ◽  
pp. 435-440 ◽  
Author(s):  
Hengbing Wang ◽  
Qi Li ◽  
Xiaobing Niu ◽  
Gongcheng Wang ◽  
Sinian Zheng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cancer Cell Proliferation

scholarly journals ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Haifan Yang ◽  
Ge Li ◽  
Bo Cheng ◽  
Rui Jiang
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Biological Function ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Long non-coding RNA (lncRNA) ZFAS1 (zinc finger antisense 1) has been suggested to have an oncogenic role in the tumorigenesis of human malignant tumors. However, the expression status and biological function of ZFAS1 in bladder cancer is still unknown. Thus, the purpose of the present study is to explore the clinical value of ZFAS1 in bladder cancer patients, and the biological function of ZFAS1 in bladder cancer cell. In the present study, we found ZFAS1 expression was increased in bladder cancer tissues compared with paired adjacent normal tissues through analyzing the Cancer Genome Atlas (TCGA) database. Furthermore, we confirmed that levels of ZFAS1 expression were elevated in bladder cancer tissues and cell lines compared with normal bladder tissues and normal uroepithelium cell line, respectively. Then, we observed that the expression level of ZFAS1 was positively associated with clinical stag, muscularis invasion, lymph node metastasis, and distant metastasis in bladder cancer patients. The experiments in vitro suggested that knockdown of ZFAS1 repressed bladder cancer cell proliferation via up-regulating KLF2 and NKD2 expression, and inhibited cell migration and invasion via down-regulating ZEB1 and ZEB2 expression. In conclusion, ZFAS1 is overexpressed in bladder cancer, and functions as an oncogenic lncRNA in regulating bladder cancer cell proliferation, migration, and invasion.

scholarly journals FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guanwen Zhou ◽  
Keqiang Yan ◽  
Jikai Liu ◽  
Lijian Gao ◽  
Xianzhou Jiang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Prognostic Biomarker ◽  
Critical Role ◽  
Bladder Cancer Cell ◽  
Dependent Manner ◽  
Cancer Cell Proliferation ◽  
Aberrant Expression

AbstractThe aberrant expression of fat mass and obesity-associated protein (FTO) has been confirmed to be associated with a variety of cancers and participates in the regulation of multiple biological behaviours. FTO plays an oncogenic role in bladder cancer, but few studies have focused on how FTO promotes bladder cancer progression by regulating miRNA synthesis. Here, we confirmed that FTO expression was significantly increased in bladder cancer and was associated with a poor prognosis. FTO overexpression promoted bladder cancer cell proliferation, whereas FTO knockdown inhibited bladder cancer cell proliferation. We also demonstrated that FTO promoted bladder cancer cell proliferation via the FTO/miR-576/CDK6 pathways. Taken together, our work revealed that FTO plays a critical role in bladder cancer and could be a potential diagnostic or prognostic biomarker for this disease.

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