scholarly journals Glucocorticoid-Inducible Kinase 2 Promotes Bladder Cancer Cell Proliferation, Migration and Invasion by Enhancing β-catenin/c-Myc Signaling Pathway

2018 ◽  
Vol 9 (24) ◽  
pp. 4774-4782 ◽  
Author(s):  
Jin-Bo Chen ◽  
Meng Zhang ◽  
Xiao-Long Zhang ◽  
Yu Cui ◽  
Pei-Hua Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation

scholarly journals lncRNA CCAT1 promotes bladder cancer cell proliferation, migration and invasion

2019 ◽  
Vol 45 (3) ◽  
pp. 549-559 ◽  
Author(s):  
Caixiang Zhang ◽  
Wenying Wang ◽  
Jun Lin ◽  
Jing Xiao ◽  
Ye Tian
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation

scholarly journals ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Haifan Yang ◽  
Ge Li ◽  
Bo Cheng ◽  
Rui Jiang
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Biological Function ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Long non-coding RNA (lncRNA) ZFAS1 (zinc finger antisense 1) has been suggested to have an oncogenic role in the tumorigenesis of human malignant tumors. However, the expression status and biological function of ZFAS1 in bladder cancer is still unknown. Thus, the purpose of the present study is to explore the clinical value of ZFAS1 in bladder cancer patients, and the biological function of ZFAS1 in bladder cancer cell. In the present study, we found ZFAS1 expression was increased in bladder cancer tissues compared with paired adjacent normal tissues through analyzing the Cancer Genome Atlas (TCGA) database. Furthermore, we confirmed that levels of ZFAS1 expression were elevated in bladder cancer tissues and cell lines compared with normal bladder tissues and normal uroepithelium cell line, respectively. Then, we observed that the expression level of ZFAS1 was positively associated with clinical stag, muscularis invasion, lymph node metastasis, and distant metastasis in bladder cancer patients. The experiments in vitro suggested that knockdown of ZFAS1 repressed bladder cancer cell proliferation via up-regulating KLF2 and NKD2 expression, and inhibited cell migration and invasion via down-regulating ZEB1 and ZEB2 expression. In conclusion, ZFAS1 is overexpressed in bladder cancer, and functions as an oncogenic lncRNA in regulating bladder cancer cell proliferation, migration, and invasion.

scholarly journals MEST promotes bladder cancer cell proliferation, migration and invasion via STAT3/Twist-1-mediated EMT

2020 ◽  
Vol 9 (10) ◽  
pp. 6178-6188
Author(s):  
Cheng Zhao ◽  
Xiheng Hu ◽  
Shiyu Tong ◽  
Miao Mo ◽  
Wei He ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Twist 1

scholarly journals ZKSCAN3 promotes bladder cancer cell proliferation, migration, and invasion

Oncotarget ◽  
2016 ◽  
Vol 7 (33) ◽  
pp. 53599-53610 ◽  
Author(s):  
Takashi Kawahara ◽  
Satoshi Inoue ◽  
Hiroki Ide ◽  
Eiji Kashiwagi ◽  
Shinji Ohtake ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation
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