High dose black cohosh extract for climacteric complaints

2013 ◽  
Vol 18 (4) ◽  
pp. 203-204
Author(s):  
S Chrubasik ◽  
J Drewe
Keyword(s):  
Black Cohosh ◽  
High Dose ◽  
Climacteric Complaints

The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa)

2014 ◽  
Vol 139 ◽  
pp. 302-310 ◽  
Author(s):  
Wolfgang Wuttke ◽  
Hubertus Jarry ◽  
Jutta Haunschild ◽  
Guenter Stecher ◽  
Markus Schuh ◽  
...  
Keyword(s):  
Black Cohosh ◽  
Actaea Racemosa ◽  
Climacteric Complaints

scholarly journals Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 766 ◽  
Author(s):  
Jöhrer ◽  
Stuppner ◽  
Greil ◽  
Çiçek
Keyword(s):  
Multiple Myeloma ◽  
Myeloma Cell ◽  
Black Cohosh ◽  
Active Constituent ◽  
Substitution Pattern ◽  
Multiple Myeloma Cell ◽  
Actaea Racemosa ◽  
Cytotoxic Compounds ◽  
Climacteric Complaints

Black cohosh is a well-established medicinal plant and preparations of its rootstock are used for the treatment of mild climacteric complaints. The compounds considered responsible for the therapeutic effect are triterpene glycosides, characterized by a cycloartane scaffold and a pentose moiety. Because some of these triterpenoids were found to exhibit relevant cytotoxic effects against human breast cancer cells, we decided to investigate their activity on multiple myeloma cell lines NCI-H929, OPM-2, and U266. In a systematic approach, we initially tested three known cytotoxic compounds of three different triterpenoid types, revealing the cimigenol-type triterpenoid as the most active constituent. In a second round, seven naturally occurring cimigenol derivatives were compared with respect to their sugar moiety and their substitution pattern at position C-25, leading to 25-O-methylcimigenol-3-O-α-L-arabinopyranoside as the most potent candidate. Interestingly, not only the methyl group at position C-25 increased the cytotoxic effect but also the arabinose moiety at position C-3 had an impact on the activity. The variety of cimigenol derivatives, moreover, allowed a detailed discussion of their structure–activity relationships, not only for their effect on multiple myeloma cells but also with regard to previous studies on the cytotoxicity of black cohosh triterpenoids.

Black Cohosh and St. John’s Wort for Climacteric Complaints

2006 ◽  
Vol 107 (2, Part 1) ◽  
pp. 247-255 ◽  
Author(s):  
Ralf Uebelhack ◽  
Jens-Uwe Blohmer ◽  
Hans-Joachim Graubaum ◽  
Regina Busch ◽  
Joerg Gruenwald ◽  
...  
Keyword(s):  
Black Cohosh ◽  
St John’S Wort ◽  
St John's Wort ◽  
Climacteric Complaints

Effects of high-dose RU-486 treatment on climacteric complaints in hysterectomized postmenopausal women: a 6-week pilot study

2004 ◽  
Vol 115 (1) ◽  
pp. 115-116
Author(s):  
Marieke O Verhoeven ◽  
Herjan J.T Coelingh Bennink ◽  
René F van der Linden ◽  
Marius J van der Mooren
Keyword(s):  
Pilot Study ◽  
Postmenopausal Women ◽  
High Dose ◽  
Ru 486 ◽  
Climacteric Complaints

Electron Beam Damage of Biomolecules Assessed by Energy Loss Spectroscopy

1978 ◽  
Vol 36 (3) ◽  
pp. 61-69
Author(s):  
M. Isaacson ◽  
M.L. Collins ◽  
M. Listvan
Keyword(s):  
Electron Microscopy ◽  
Radiation Damage ◽  
Structural Integrity ◽  
Analytical Electron Microscopy ◽  
High Dose ◽  
Dose Rates ◽  
Special Cases ◽  
Analytical Electron ◽  
Atom Migration ◽  
Beam Damage

Over the past five years it has become evident that radiation damage provides the fundamental limit to the study of blomolecular structure by electron microscopy. In some special cases structural determinations at very low doses can be achieved through superposition techniques to study periodic (Unwin & Henderson, 1975) and nonperiodic (Saxton & Frank, 1977) specimens. In addition, protection methods such as glucose embedding (Unwin & Henderson, 1975) and maintenance of specimen hydration at low temperatures (Taylor & Glaeser, 1976) have also shown promise. Despite these successes, the basic nature of radiation damage in the electron microscope is far from clear. In general we cannot predict exactly how different structures will behave during electron Irradiation at high dose rates. Moreover, with the rapid rise of analytical electron microscopy over the last few years, nvicroscopists are becoming concerned with questions of compositional as well as structural integrity. It is important to measure changes in elemental composition arising from atom migration in or loss from the specimen as a result of electron bombardment.

Electron-diffraction studies in synthetic polymer materials

1983 ◽  
Vol 41 ◽  
pp. 362-365
Author(s):  
D.T. Grubb
Keyword(s):  
Electron Diffraction ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Crystallographic Structure ◽  
High Dose ◽  
Electron Dose ◽  
Dose Rates ◽  
First Case ◽  
Diffraction Patterns ◽  
The Many

Diffraction studies in polymeric and other beam sensitive materials may bring to mind the many experiments where diffracted intensity has been used as a measure of the electron dose required to destroy fine structure in the TEM. But this paper is concerned with a range of cases where the diffraction pattern itself contains the important information.In the first case, electron diffraction from paraffins, degraded polyethylene and polyethylene single crystals, all the samples are highly ordered, and their crystallographic structure is well known. The diffraction patterns fade on irradiation and may also change considerably in a-spacing, increasing the unit cell volume on irradiation. The effect is large and continuous far C94H190 paraffin and for PE, while for shorter chains to C 28H58 the change is less, levelling off at high dose, Fig.l. It is also found that the change in a-spacing increases at higher dose rates and at higher irradiation temperatures.

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