Vitamin D3 potentiates the nephroprotective effects of vildagliptin‐metformin combination in a rat model of metabolic syndrome

2021 ◽  
Author(s):  
Nehal S. Wahba ◽  
Rasha H. Abdel‐Ghany ◽  
Salah A. Ghareib ◽  
Mohamed Abdel‐Aal ◽  
Amira E. Alsemeh ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D3 ◽  
Rat Model

Renoprotective effects of vitamin D3 supplementation in a rat model of metabolic syndrome

2020 ◽  
Author(s):  
Nehal S. Wahba ◽  
Salah A. Ghareib ◽  
Rasha H. Abdel-Ghany ◽  
Mohamed Abdel-Aal ◽  
Amira E. Alsemeh
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D3 ◽  
Rat Model ◽  
Vitamin D3 Supplementation

Myocardial Ischemic-reperfusion Injury in a Rat Model of Metabolic Syndrome

Obesity ◽  
2008 ◽  
Vol 16 (10) ◽  
pp. 2253-2258 ◽  
Author(s):  
Mahmood S. Mozaffari ◽  
Stephen W. Schaffer
Keyword(s):  
Metabolic Syndrome ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion

scholarly journals SP074SERINE PROTEASE INHIBITION ATTENUATES SALT-SENSITIVE HYPERTENSION AND KIDNEY INJURY IN A RAT MODEL OF METABOLIC SYNDROME

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i110-i110
Author(s):  
Yutaka Kakizoe ◽  
Teruhiko Mizumoto ◽  
Terumasa Nakagawa ◽  
Manabu Hayata ◽  
Yuichiro Izumi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model ◽  
Kidney Injury ◽  
Protease Inhibition ◽  
Salt Sensitive Hypertension

scholarly journals Insulin resistance in penile arteries from a rat model of metabolic syndrome

2010 ◽  
Vol 161 (2) ◽  
pp. 350-364 ◽  
Author(s):  
Cristina Contreras ◽  
Ana Sánchez ◽  
Pilar Martínez ◽  
Rafaela Raposo ◽  
Belén Climent ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Rat Model ◽  
Penile Arteries

Evaluation of the Relationship between Vitamin D Deficiency and Atherogenic Factors in Diabetic Patients with Metabolic Syndrome

2021 ◽  
Author(s):  
Leila Akbarbaglu ◽  
Elham Nozari Mirarkolaei ◽  
Massoumeh Hotelchi ◽  
Abbas Khonakdar-Tarsi ◽  
Mahboobeh Ghanbari ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Serum Level ◽  
Total Cholesterol ◽  
Vitamin D3 ◽  
Atherogenic Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Significant Difference ◽  
25 Oh Vitamin D

Introduction: Metabolic syndrome includes a range of disorders that increase the risk of cardiovascular disease and diabetes mellitus. In this study, we examined the serum level of vitamin D3 in diabetic individuals with metabolic syndrome compared with non-diabetic individuals without metabolic syndrome and the association of serum vitamin D3 levels with metabolic syndrome and atherogenic factor (LDL/HDL). Material and Methods: In a case-control study, we included 110 women with metabolic syndrome according to ATP III criteria and 127 healthy women as a control group. Serum concentration of total cholesterol, LDL-C, FBS, HDL-C and serum triglyceride determined by enzymatic method and colorimetric and, serum level 25-(OH) vitamin D determined by ELISA. Results: It was found that the two healthy and metabolic groups were significantly different in terms of total cholesterol levels, LDL and triglyceride levels, HDL, VLDL, FBS, atherogenic index (LDL/HDL) and vitamin D levels (p<0.05). All participants in the control group and the patient and the whole study population were divided into two categories of insufficient and sufficient based on their measured serum concentrations of 25-(OH) vitamin D. There was a significant difference between the group with insufficient levels of vitamin D in comparison with the group with sufficient levels of vitamin D in terms of total cholesterol, LDL and triglyceride levels, HDL, VLDL, FBS and atherogenic index (LDL/HDL) (p=0.000). Conclusion: The present results showed that there is a significant relationship between level 25-(OH) D and atherogenic index (LDL/HDL) and the incidence of metabolic syndrome.

scholarly journals Relationship Between Dyslipidemia and Hypertension (HBP) in Male ZDSD, a New Rat Model of Metabolic Syndrome (MetS)

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
David M Eaton ◽  
Ashley N Rogers ◽  
Ami E Rice ◽  
Kathy Coy ◽  
Richard G Peterson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model

scholarly journals Improvement of Cardiac Fibrosis Biomarkers through Inflammation Inhibition by Green Tea and Decaffeinated Light Roasted Green Coffee Extract Combination Administration in Metabolic Syndrome Rat Model

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1013
Author(s):  
Mifetika Lukitasari ◽  
Mohammad Saifur Rohman ◽  
Dwi Adi Nugroho ◽  
Nila Aisyah Wahyuni ◽  
Mukhamad Nur Kholis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Green Tea ◽  
Rat Model ◽  
Cardiac Fibrosis ◽  
Significant Risk ◽  
Green Coffee ◽  
The Metabolic Syndrome ◽  
Tnf Α ◽  
Tgf Β1

Background: Metabolic syndrome is a significant risk factor for cardiovascular diseases. Green tea and green coffee extracts, antioxidant and anti-inflammatory agents may participate in metabolic syndrome-induced cardiac fibrosis alleviation. However, the effect of combination of those extracts still needs exploration. Therefore, this study investigated the effect of green tea and decaffeinated light roasted green coffee extracts and their combination in metabolic syndrome-induced cardiac fibrosis rats. Methods: Metabolic syndrome rat model was i1nduced through high-fat high sucrose diets feeding for 8 weeks and injection of low dose streptozotocin at the 2nd week. The metabolic syndrome rats were divided into 4 experimental groups metabolic syndrome rats (MS); metabolic syndrome rats treated with 300 mg/ kg b.w green tea extract (GT); metabolic syndrome rats treated with 200 mg/ kg b.w decaffeinated light roasted green coffee extract (GC); metabolic syndrome rats treated with the combination of the two extracts (CE); and a normal control (NC) group was added. Angiotensin 2 level was analyzed by ELISA method. Gene expression of NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma were analyzed by touchdown polymerase chain reaction methods. Results: Metabolic syndrome rats treated with green tea and decaffeinated light roasted green coffee significantly decreased angiotensin-2 serum level and cardiac inflammation and fibrosis gene expression level (NF-κB, TNF-α, IL-6, Tgf-β1, Rac-1, and α-sma). More significant alleviation was observed in the combination group. Conclusion: This study suggested that combination of green tea and decaffeinated light roasted green coffee extracts showed better improvement in metabolic syndrome-induced cardiac fibrosis rat model compared to that of single extract administration through inflammation inhibition

scholarly journals Hydrochlorothiazide exacerbates metabolic syndrome in the SHROB rat model

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Paul Ernsberger ◽  
Akshita Agarwal ◽  
Beth Lute ◽  
Richard J Koletsky
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model

scholarly journals The ZDSD, a New Rat Model of Metabolic Syndrome: Evidence of Cardiovascular Disease

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
C Subah Packer ◽  
Leeanna M Meulen ◽  
Alexa M Boice ◽  
Kathy Coy ◽  
Richard G Peterson
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Rat Model
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