Regeneration of rete ridges in Lanyu pig ( Sus scrofa ): Insights for human skin wound healing

2019 ◽  
Vol 28 (4) ◽  
pp. 472-479 ◽  
Author(s):  
Chein‐Hong Lin ◽  
Po‐Yuan Chiu ◽  
Yuan‐Yu Hsueh ◽  
Shyh‐Jou Shieh ◽  
Chia‐Ching Wu ◽  
...  
Author(s):  
Alexandr Basov ◽  
Liliya Fedulova ◽  
Ekaterina Vasilevskaya ◽  
Ekaterina Trofimova ◽  
Nataliya Murashova ◽  
...  

2013 ◽  
Vol 133 (3) ◽  
pp. 856-858 ◽  
Author(s):  
Marcia L. Usui ◽  
Robert A. Underwood ◽  
Philip. Fleckman ◽  
John E. Olerud

2021 ◽  
Vol 141 (10) ◽  
pp. S210
Author(s):  
Z. Liu ◽  
L. Zhang ◽  
MA. Toma ◽  
P. Sommar ◽  
N.X. Landén

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Atsuki Mori ◽  
Koji Sugawara ◽  
Daisuke Tsuruta ◽  
Isao Matsui‐Yuasa ◽  
Akiko Kojima‐Yuasa

2020 ◽  
Author(s):  
Carlos Poblete Jara ◽  
Carolina Motter Catarino ◽  
Yuguo Lei ◽  
Lício Augusto Velloso ◽  
Pankaj Karande ◽  
...  

AbstractObjectiveThe development of an in vitro platform for modeling human skin injury and the re-epithelization process.ApproachA fibrin provisional matrix (FPM) was installed into a wound facsimile of a bioprinted human skin equivalent (HSE). A mixture of plasma-derived fibrinogen-containing factor XIII, fibronectin, thrombin, and macrophages (an FPM “bioink”) was extruded into the wound site. The surrounding in vitro tissue culture became a source of keratinocytes to achieve wound closure by a re-epithelialization process signaled by the FPM.ResultsAn in vitro analog of wound closure and re-epithelialization by keratinocytes occurred over the FPM after a normal migration initiation at 3 days.InnovationA physiologic mixture of macrophage/fibrinogen/fibronectin that supports macrophage differentiation was applied to a mechanically wounded, bioprinted dermal tissue. We developed a transitional culture medium to mimic the changing microenvironment during the initial phases of wound healing. As a reference, we temporally compared our in vitro model with a murine skin wound healing.ConclusionThis co-culture model was shown to temporally synchronize a re-epithelization process for initiation of keratinocyte migration from a surrounding tissue and the migration process over the top of an FPM. A future study of the analogous subepithelial healing pathway is envisioned using the same in vitro bioprinted tissue study platform for co-culture of keratinocytes, melanocytes, fibroblasts, endothelial cells, and macrophages using more specialized FPMs.


1995 ◽  
Vol 27 (3) ◽  
pp. 158-166 ◽  
Author(s):  
F. Vaxman ◽  
S. Olender ◽  
A. Lambert ◽  
G. Nisand ◽  
M. Aprahamian ◽  
...  

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