scholarly journals Parakeratotic Corneocytes Play a Unique Role in Human Skin Wound Healing

2013 ◽  
Vol 133 (3) ◽  
pp. 856-858 ◽  
Author(s):  
Marcia L. Usui ◽  
Robert A. Underwood ◽  
Philip. Fleckman ◽  
John E. Olerud
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Unique Role

scholarly journals 350 The landscape of microRNA-mediated gene regulation in human skin wound healing and venous ulcers

2021 ◽  
Vol 141 (10) ◽  
pp. S210
Author(s):  
Z. Liu ◽  
L. Zhang ◽  
MA. Toma ◽  
P. Sommar ◽  
N.X. Landén
Keyword(s):  
Wound Healing ◽  
Gene Regulation ◽  
Human Skin ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Venous Ulcers

scholarly journals 1′‐Acetoxychavicol acetate accelerates human skin wound healing

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Atsuki Mori ◽  
Koji Sugawara ◽  
Daisuke Tsuruta ◽  
Isao Matsui‐Yuasa ◽  
Akiko Kojima‐Yuasa
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Skin Wound ◽  
Skin Wound Healing

Regeneration of rete ridges in Lanyu pig ( Sus scrofa ): Insights for human skin wound healing

2019 ◽  
Vol 28 (4) ◽  
pp. 472-479 ◽  
Author(s):  
Chein‐Hong Lin ◽  
Po‐Yuan Chiu ◽  
Yuan‐Yu Hsueh ◽  
Shyh‐Jou Shieh ◽  
Chia‐Ching Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Sus Scrofa ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Demonstration of re-epithelialization in a bioprinted human skin equivalent wound model

2020 ◽  
Author(s):  
Carlos Poblete Jara ◽  
Carolina Motter Catarino ◽  
Yuguo Lei ◽  
Lício Augusto Velloso ◽  
Pankaj Karande ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Wound Closure ◽  
Skin Wound ◽  
Skin Equivalent ◽  
Surrounding Tissue ◽  
Skin Wound Healing ◽  
Over The Top ◽  
Human Skin Equivalent

AbstractObjectiveThe development of an in vitro platform for modeling human skin injury and the re-epithelization process.ApproachA fibrin provisional matrix (FPM) was installed into a wound facsimile of a bioprinted human skin equivalent (HSE). A mixture of plasma-derived fibrinogen-containing factor XIII, fibronectin, thrombin, and macrophages (an FPM “bioink”) was extruded into the wound site. The surrounding in vitro tissue culture became a source of keratinocytes to achieve wound closure by a re-epithelialization process signaled by the FPM.ResultsAn in vitro analog of wound closure and re-epithelialization by keratinocytes occurred over the FPM after a normal migration initiation at 3 days.InnovationA physiologic mixture of macrophage/fibrinogen/fibronectin that supports macrophage differentiation was applied to a mechanically wounded, bioprinted dermal tissue. We developed a transitional culture medium to mimic the changing microenvironment during the initial phases of wound healing. As a reference, we temporally compared our in vitro model with a murine skin wound healing.ConclusionThis co-culture model was shown to temporally synchronize a re-epithelization process for initiation of keratinocyte migration from a surrounding tissue and the migration process over the top of an FPM. A future study of the analogous subepithelial healing pathway is envisioned using the same in vitro bioprinted tissue study platform for co-culture of keratinocytes, melanocytes, fibroblasts, endothelial cells, and macrophages using more specialized FPMs.

Effect of Pantothenic Acid and Ascorbic Acid Supplementation on Human Skin Wound Healing Process

1995 ◽  
Vol 27 (3) ◽  
pp. 158-166 ◽  
Author(s):  
F. Vaxman ◽  
S. Olender ◽  
A. Lambert ◽  
G. Nisand ◽  
M. Aprahamian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ascorbic Acid ◽  
Human Skin ◽  
Healing Process ◽  
Pantothenic Acid ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Wound Healing ◽  
Acid Supplementation ◽  
Ascorbic Acid Supplementation

scholarly journals Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saskia Seiser ◽  
Lukas Janker ◽  
Nina Zila ◽  
Michael Mildner ◽  
Ana Rakita ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Ex Vivo ◽  
Skin Wound ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tape Stripping ◽  
Skin Wound Healing ◽  
Wound Model ◽  
Octenidine Dihydrochloride ◽  
Anti Inflammatory

AbstractOctenidine dihydrochloride (OCT) is a widely used antiseptic molecule, promoting skin wound healing accompanied with improved scar quality after surgical procedures. However, the mechanisms by which OCT is contributing to tissue regeneration are not yet completely clear. In this study, we have used a superficial wound model by tape stripping of ex vivo human skin. Protein profiles of wounded skin biopsies treated with OCT-containing hydrogel and the released secretome were analyzed using liquid chromatography-mass spectrometry (LC–MS) and enzyme-linked immunosorbent assay (ELISA), respectively. Proteomics analysis of OCT-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines (IL-8, IL-6) and matrix-metalloproteinases (MMP1, MMP2, MMP3, MMP9) when compared to controls. In addition, enzymatic activity of several released MMPs into culture supernatants was significantly lower in OCT-treated samples. Our data give insights on the mode of action based on which OCT positively influences wound healing and identified anti-inflammatory and protease-inhibitory activities of OCT.

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