scholarly journals The keratin 16 null phenotype is modestly impacted by genetic strain background in mice

2018 ◽  
Vol 27 (6) ◽  
pp. 672-674 ◽  
Author(s):  
Abigail Zieman ◽  
Pierre A. Coulombe
Keyword(s):  
Keratin 16 ◽  
Genetic Strain ◽  
Null Phenotype ◽  
Strain Background

scholarly journals ThemecAHomologmecCConfers Resistance against β-Lactams in Staphylococcus aureus Irrespective of the Genetic Strain Background

2014 ◽  
Vol 58 (7) ◽  
pp. 3791-3798 ◽  
Author(s):  
Britta Ballhausen ◽  
André Kriegeskorte ◽  
Nina Schleimer ◽  
Georg Peters ◽  
Karsten Becker
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Regulatory System ◽  
Wild Type ◽  
Beta Lactam ◽  
Beta Lactams ◽  
Content Type ◽  
Genetic Strain ◽  
Mrsa Strains ◽  
Strain Background

ABSTRACTIn staphylococci, methicillin resistance is mediated bymecA-encoded penicillin-binding protein 2a (PBP2a), which has a low affinity for beta-lactams. Recently, a novel PBP2a homolog was described as being encoded bymecC, which shares only 70% similarity tomecA. To prove thatmecCis the genetic determinant that confers methicillin resistance inStaphylococcus aureus, amecCknockout strain was generated. TheS. aureusΔmecCstrain showed considerably reduced oxacillin and cefoxitin MICs (0.25 and 4 μg/ml, respectively) compared to those of the corresponding wild-type methicillin-resistantS. aureus(MRSA) strain (8 and 16 μg/ml, respectively). Complementing the mutant intranswith wild-typemecCrestored the resistance to oxacillin and cefoxitin. By expressingmecCandmecAin differentS. aureusclonal lineages, we found thatmecCmediates resistance irrespective of the genetic strain background, yielding oxacillin and cefoxitin MIC values comparable to those withmecA. In addition, we showed thatmecCexpression is inducible by oxacillin, which supports the assumption that a functional beta-lactam-dependent regulatory system is active in MRSA strains possessing staphylococcal cassette chromosomemec(SCCmec) type XI. In summary, we showed thatmecCis inducible by oxacillin and mediates beta-lactam resistance in SCCmectype XI-carrying strains as well as in differentS. aureusgenetic backgrounds. Furthermore, our results could explain the comparatively low MICs for clinicalmecC-harboringS. aureusisolates.

GENETIC STRAIN BACKGROUND INFLUENCES THE PHENOTYPIC EFFECTS OF THE MOUSE WEAVER GENE

1997 ◽  
Vol 56 (5) ◽  
pp. 587
Author(s):  
S. R. Dlouhy ◽  
T. Verinn ◽  
J. J. Wei ◽  
J. Richter ◽  
C. Stauss ◽  
...  
Keyword(s):  
Genetic Strain ◽  
Strain Background

scholarly journals Effects of Broiler Genetic Strain and Dietary Amino Acid Reduction on Meat Yield and Quality (Part II)

2021 ◽  
pp. 101033
Author(s):  
Bo Zhang ◽  
Xue Zhang ◽  
M. Wes Schilling ◽  
Xiaofei Li ◽  
George T. Tabler ◽  
...  
Keyword(s):  
Amino Acid ◽  
Meat Yield ◽  
Yield And Quality ◽  
Genetic Strain ◽  
Dietary Amino Acid ◽  
Acid Reduction

Cytogenetic Investigation of the Rh(null) Phenotype

Vox Sanguinis ◽  
1974 ◽  
Vol 27 (2) ◽  
pp. 190-192
Author(s):  
W.L. Marsh ◽  
R.S.K. Chaganti ◽  
James German ◽  
S. Seidl ◽  
W. Spielmann
Keyword(s):  
Cytogenetic Investigation ◽  
Null Phenotype

scholarly journals Molecular Basis of the Kell-null Phenotype

2000 ◽  
Vol 276 (13) ◽  
pp. 10247-10252 ◽  
Author(s):  
Lung-Chih Yu ◽  
Yuh-Ching Twu ◽  
Ching-Yi Chang ◽  
Marie Lin
Keyword(s):  
Molecular Basis ◽  
Null Phenotype
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