scholarly journals Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule

2015 ◽  
Vol 25 (1) ◽  
pp. 74-76 ◽  
Author(s):  
Chunbao Rao ◽  
Zhongyuan Su ◽  
Huirong Li ◽  
Xiaoyin Ma ◽  
Xiaozi Zheng ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Melanoma Cell Adhesion Molecule

scholarly journals Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer

2020 ◽  
Vol 21 (24) ◽  
pp. 9776
Author(s):  
Kazuhisa Kitami ◽  
Masato Yoshihara ◽  
Yoshihiro Koya ◽  
Mai Sugiyama ◽  
Shohei Iyoshi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Transcription Factor ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Peritoneal Metastasis ◽  
Cell Adhesion Molecule ◽  
Progression Free Survival ◽  
Significant Prognostic Factor ◽  
Melanoma Cell Adhesion Molecule

Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. In this study, we investigated the function of microphthalmia-associated transcription factor (MITF), which contributes to the development of melanoma, in epithelial ovarian cancer (OvCa). High MITF expression was significantly associated with a poor prognosis in OvCa. Notably, MITF contributed to the motility and invasion of OvCa cells, and specifically with their peri-mesothelial migration. In addition, MITF-positive cells expressed the melanoma cell adhesion molecule (MCAM/CD146), which was initially identified as a marker of melanoma progression and metastasis, and MCAM expression was regulated by MITF. MCAM was also identified as a significant prognostic factor for poor progression-free survival in patients with OvCa. Collectively, our results suggest that MITF is a novel therapeutic target that potentially promotes peritoneal metastasis of OvCa.

scholarly journals CD146, from a melanoma cell adhesion molecule to a signaling receptor

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Zhaoqing Wang ◽  
Qingji Xu ◽  
Nengwei Zhang ◽  
Xuemei Du ◽  
Guangzhong Xu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Melanoma Cell Adhesion Molecule

scholarly journals Melanoma cell adhesion molecule as an emerging biomarker with prognostic significance in systolic heart failure

2016 ◽  
Vol 10 (7) ◽  
pp. 733-742 ◽  
Author(s):  
Joanna Banach ◽  
Magdalena Grochowska ◽  
Lidia Gackowska ◽  
Katarzyna Buszko ◽  
Robert Bujak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Prognostic Significance ◽  
Systolic Heart Failure ◽  
Melanoma Cell Adhesion Molecule

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

2015 ◽  
Vol 78 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Catherine Larochelle ◽  
Marc-André Lécuyer ◽  
Jorge Ivan Alvarez ◽  
Marc Charabati ◽  
Olivia Saint-Laurent ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Adhesion ◽  
T Lymphocytes ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Central Nervous System Inflammation ◽  
Cd8 T Lymphocytes ◽  
Melanoma Cell Adhesion Molecule
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