scholarly journals Human fetal skeletal muscle contains a myogenic side population that expresses the melanoma cell-adhesion molecule

2012 ◽  
Vol 21 (16) ◽  
pp. 3668-3680 ◽  
Author(s):  
Ariya D. Lapan ◽  
Anete Rozkalne ◽  
Emanuela Gussoni
Keyword(s):  
Skeletal Muscle ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Side Population ◽  
Melanoma Cell Adhesion Molecule

scholarly journals CD146, from a melanoma cell adhesion molecule to a signaling receptor

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Zhaoqing Wang ◽  
Qingji Xu ◽  
Nengwei Zhang ◽  
Xuemei Du ◽  
Guangzhong Xu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Melanoma Cell Adhesion Molecule

scholarly journals Melanoma cell adhesion molecule as an emerging biomarker with prognostic significance in systolic heart failure

2016 ◽  
Vol 10 (7) ◽  
pp. 733-742 ◽  
Author(s):  
Joanna Banach ◽  
Magdalena Grochowska ◽  
Lidia Gackowska ◽  
Katarzyna Buszko ◽  
Robert Bujak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Prognostic Significance ◽  
Systolic Heart Failure ◽  
Melanoma Cell Adhesion Molecule

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

2015 ◽  
Vol 78 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Catherine Larochelle ◽  
Marc-André Lécuyer ◽  
Jorge Ivan Alvarez ◽  
Marc Charabati ◽  
Olivia Saint-Laurent ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Adhesion ◽  
T Lymphocytes ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Central Nervous System Inflammation ◽  
Cd8 T Lymphocytes ◽  
Melanoma Cell Adhesion Molecule

scholarly journals Melanoma Cell Adhesion Molecule Expressing Helper T Cells in CNS Inflammatory Demyelinating Diseases

2021 ◽  
Vol 8 (6) ◽  
pp. e1069
Author(s):  
Ryotaro Ikeguchi ◽  
Yuko Shimizu ◽  
Akihiro Kondo ◽  
Natsuki Kanda ◽  
Hayato So ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Absolute Number ◽  
Demyelinating Diseases ◽  
Helper T Cells ◽  
Melanoma Cell Adhesion Molecule ◽  
The Absolute

Background and ObjectiveTo elucidate the relationship between melanoma cell adhesion molecule (MCAM)-expressing lymphocytes and pathogenesis of CNS inflammatory demyelinating diseases (IDDs).MethodsPatients with multiple sclerosis (MS) (n = 72) and neuromyelitis optica spectrum disorder (NMOSD, n = 29) were included. We analyzed the frequency and absolute numbers of MCAM+ lymphocytes (memory helper T [mTh] cells, naive helper T cells, CD8+ T cells, and B cells) in the peripheral blood (PB) and the CSF of patients with MS and NMOSD, treated with/without disease-modifying drugs (DMDs) or steroids, using flow cytometry.ResultsThe frequency of MCAM+ cells was higher in the mTh cell subset than that in other lymphocyte subsets. A significant increase in the frequency and the absolute number of MCAM+ mTh cells was observed in the PB of patients with NMOSD, whereas no increase was observed in the PB of patients with MS. The frequency of CSF MCAM+ mTh cells was higher in relapsing patients with MS and NMOSD than that in the control group. Although there was no difference in the frequencies of MCAM+ lymphocytes among the DMD-treated groups, fingolimod decreased the absolute number of MCAM+ lymphocytes.DiscussionMCAM+ mTh cells were elevated in the CSF of relapsing patients with MS and in both the PB and CSF of patients with NMOSD. These results indicate that MCAM contributes to the pathogenesis of MS and NMOSD through different mechanisms. MCAM could be a therapeutic target of CNS IDDs, and further study is needed to elucidate the underlying mechanism of MCAM in CNS IDD pathogenesis.

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