scholarly journals Identifying mouse models for skin cancer using the Mouse Tumor Biology Database

2014 ◽  
Vol 23 (10) ◽  
pp. 761-763 ◽  
Author(s):  
Dale A. Begley ◽  
Debra M. Krupke ◽  
Steven B. Neuhauser ◽  
Joel E. Richardson ◽  
Paul N. Schofield ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Mouse Models ◽  
Tumor Biology ◽  
Mouse Tumor

scholarly journals Mouse Tumor Biology (MTB): a database of mouse models for human cancer

2014 ◽  
Vol 43 (D1) ◽  
pp. D818-D824 ◽  
Author(s):  
Carol J. Bult ◽  
Debra M. Krupke ◽  
Dale A. Begley ◽  
Joel E. Richardson ◽  
Steven B. Neuhauser ◽  
...  
Keyword(s):  
Mouse Models ◽  
Human Cancer ◽  
Tumor Biology ◽  
Mouse Tumor

scholarly journals Abstract 5102: Identifying relevant mouse models of human cancer using the mouse tumor biology database (MTB)

2018 ◽  
Author(s):  
Dale A. Begley ◽  
Debra M. Krupke ◽  
Steven B. Neuhauser ◽  
Joel E. Richardson ◽  
John P. Sundberg ◽  
...  
Keyword(s):  
Mouse Models ◽  
Human Cancer ◽  
Tumor Biology ◽  
Mouse Tumor

scholarly journals The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer

2017 ◽  
Vol 77 (21) ◽  
pp. e67-e70 ◽  
Author(s):  
Debra M. Krupke ◽  
Dale A. Begley ◽  
John P. Sundberg ◽  
Joel E. Richardson ◽  
Steven B. Neuhauser ◽  
...  
Keyword(s):  
Mouse Models ◽  
Human Cancer ◽  
Tumor Biology ◽  
Mouse Tumor

scholarly journals Finding mouse models of human lymphomas and leukemia's using the Jackson laboratory mouse tumor biology database

2015 ◽  
Vol 99 (3) ◽  
pp. 533-536 ◽  
Author(s):  
Dale A. Begley ◽  
John P. Sundberg ◽  
Debra M. Krupke ◽  
Steven B. Neuhauser ◽  
Carol J. Bult ◽  
...  
Keyword(s):  
Mouse Models ◽  
Laboratory Mouse ◽  
Tumor Biology ◽  
Mouse Tumor ◽  
Jackson Laboratory

scholarly journals Electronic access to mouse tumor data: the Mouse Tumor Biology Database (MTB) project

1999 ◽  
Vol 27 (1) ◽  
pp. 99-105 ◽  
Author(s):  
C. J. Bult ◽  
D. M. Krupke ◽  
J. T. Eppig
Keyword(s):  
Tumor Biology ◽  
Mouse Tumor ◽  
Electronic Access

scholarly journals MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Kent Riemondy ◽  
Xiao-jing Wang ◽  
Enrique C Torchia ◽  
Dennis R Roop ◽  
Rui Yi
Keyword(s):  
Cell Division ◽  
Skin Cancer ◽  
Mouse Model ◽  
Mouse Models ◽  
Knockout Mouse ◽  
Selection Process ◽  
Tumor Initiating Cells ◽  
Knockout Mouse Model ◽  
Active Selection ◽  
The Impact

In many mouse models of skin cancer, only a few tumors typically form even though many cells competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an active selection process for tumor-initiating cells. Here, we use quantitative mRNA- and miR-Seq to determine the impact of HrasG12V on the transcriptome of keratinocytes. We discover that microRNA-203 is downregulated by HrasG12V. Using a knockout mouse model, we demonstrate that loss of microRNA-203 promotes selection and expansion of tumor-initiating cells. Conversely, restoration of microRNA-203 using an inducible model potently inhibits proliferation of these cells. We comprehensively identify microRNA-203 targets required for Hras-initiated tumorigenesis. These targets include critical regulators of the Ras pathway and essential genes required for cell division. This study establishes a role for the loss of microRNA-203 in promoting selection and expansion of Hras mutated cells and identifies a mechanism through which microRNA-203 antagonizes Hras-mediated tumorigenesis.

Mouse Models of Nonmelanoma Skin Cancer

2015 ◽  
pp. 217-250 ◽  
Author(s):  
Nicole Amberg ◽  
Martin Holcmann ◽  
Elisabeth Glitzner ◽  
Philipp Novoszel ◽  
Gabriel Stulnig ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Mouse Models ◽  
Nonmelanoma Skin Cancer

Abstract B50: Mouse Tumor Biology (MTB) database–An integrated data resource for GEM, inbred strains, and PDX models of human cancer

2018 ◽  
Author(s):  
Debra M. Krupke ◽  
Dale A. Begley ◽  
Steven B. Neuhauser ◽  
Joel E. Richardson ◽  
John P. Sundberg ◽  
...  
Keyword(s):  
Human Cancer ◽  
Tumor Biology ◽  
Inbred Strains ◽  
Mouse Tumor ◽  
Data Resource ◽  
Pdx Models

Abstract C18: Interpreting the cancer genome using the Mouse Tumor Biology (MTB) Database

2013 ◽  
Author(s):  
Debra M. Krupke ◽  
Dale A. Begley ◽  
Steven B. Neuhauser ◽  
Joel E. Richardson ◽  
John P. Sundberg ◽  
...  
Keyword(s):  
Tumor Biology ◽  
Cancer Genome ◽  
Mouse Tumor
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