scholarly journals Symmetric dimethylarginine and renal function analysis in horses with dehydration

2021 ◽  
Author(s):  
Hsiao‐Chien Lo ◽  
Judith C. Winter ◽  
Heidrun Gehlen ◽  
Roswitha Merle
Keyword(s):  
Renal Function ◽  
Function Analysis ◽  
Symmetric Dimethylarginine

scholarly journals Assessment of symmetric dimethylarginine as a biomarker of renal function in hyperthyroid cats treated with radioiodine

2019 ◽  
Vol 33 (2) ◽  
pp. 516-522 ◽  
Author(s):  
Eva Buresova ◽  
Emmelie Stock ◽  
Dominique Paepe ◽  
Lisa Stammeleer ◽  
Eva Vandermeulen ◽  
...  
Keyword(s):  
Renal Function ◽  
Symmetric Dimethylarginine

Differential Renal Function Analysis in Unilateral Renal Disease

1966 ◽  
Vol 96 (3) ◽  
pp. 283-285
Author(s):  
F. Peter Kohler ◽  
Howard M. Rawnsley ◽  
John J. Murphy
Keyword(s):  
Renal Function ◽  
Renal Disease ◽  
Function Analysis ◽  
Differential Renal Function

scholarly journals Renal function analysis and dehydrated status in horses

2021 ◽  
Vol 37 (2) ◽  
pp. 156–164-156–164
Author(s):  
H-C Lo ◽  
J C Winter ◽  
H Gehlen
Keyword(s):  
Renal Function ◽  
Function Analysis

scholarly journals Evaluation of renal biomarkers, including symmetric dimethylarginine, following gentamicin-induced proximal tubular injury in the rat

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0006542020
Author(s):  
Diane M Hamlin ◽  
A. Eric Schultze ◽  
Michael J. Coyne ◽  
Donald J. McCrann ◽  
Rebekah Mack ◽  
...  
Keyword(s):  
Renal Function ◽  
Control Group ◽  
Analytical Sensitivity ◽  
Symmetric Dimethylarginine ◽  
Serum Cystatin C ◽  
Rat Serum ◽  
Proximal Tubular ◽  
Renal Biomarker ◽  
Biomarker Evaluation ◽  
Dose Levels

Symmetric dimethylarginine (SDMA) is an excretory renal function biomarker shown to correlate well with glomerular filtration rate in dogs, cats, humans, and rats. The objectives of this study were to determine utility of serum SDMA as a renal biomarker in a rat model of gentamicin-induced renal injury and provide validation of a commercially available SDMA immunoassay for rat serum. Rats were randomly assigned to one of three dose levels of gentamicin (20, 50, or 100 mg/kg) or a vehicle control group and dosed once daily by subcutaneous injection for either four or ten days. Serum and urine renal biomarker evaluation including serum SDMA, hematologic and serum biochemical analysis, urinalysis, and histologic examination of kidney were performed. Prior to biologic validation, analytic validation of the SDMA immunoassay for rat serum was performed including assessment of assay accuracy, precision, analytical sensitivity, linearity, analyte stability, and interference testing. Among markers of excretory renal function SDMA and serum creatinine increased earliest and at the lowest gentamicin concentrations and were significantly increased in both the 50 mg/kg and the 100 mg/kg dosage levels in the 4 and 10-dose treatment groups compared to controls. Time- and dose-dependent increases were noted for all urinary biomarkers investigated in this study, with µALB being most responsive and OPN least responsive for detection of gentamicin-induced injury across dose levels and schedules investigated. The SDMA immunoassay met all set quality requirements assessed in analytical validation. This study is the first to investigate performance of serum SDMA as compared to other excretory renal function markers in a rat gentamicin acute toxicity model. In this study serum SDMA was an earlier biomarker for detection of gentamicin-induced toxicity than serum cystatin C, BUN, and creatinine clearance. The SDMA immunoassay provides a reliable commercially available assay for future renal investigations in rat models.

Anti-Xa Levels and Renal Function: Analysis of the First 32 Patients in the Tinzaparin in Renal Insufficiency for Venous Thromboembolism Study.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 906-906
Author(s):  
Wendy Lim ◽  
James Douketis ◽  
Luqi Wang ◽  
Karen Woods ◽  
Terri Schnurr ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Renal Function ◽  
Venous Thromboembolism ◽  
Renal Insufficiency ◽  
Therapeutic Dose ◽  
Dose Adjustment ◽  
Function Analysis ◽  
Bleeding Event ◽  
Renal Elimination ◽  
Minor Bleeding

Abstract Background: Low-molecular-weight heparin (LMWH) is renally eliminated; its use in patients with renal insufficiency may be associated with accumulation and an increased bleeding risk. Due to its higher molecular weight and greater negative charge, tinzaparin may be less dependent on renal elimination compared to other LMWHs. As a result, tinzaparin may be less prone to accumulate in patients with renal insufficiency. Purpose: To measure the anticoagulant effect of a 5-day course of therapeutic-dose tinzaparin used for the initial treatment of venous thromboembolism (VTE) in patients with varying degrees of renal insufficiency. We present the anti-Xa results of the first 32 patients enrolled in the study, correlated with renal function. Design: Prospective cohort study. Methods: In- and out-patients requiring therapeutic dose anticoagulation were enrolled and stratified into 4 groups based on creatinine clearance (CrCl): > 60 ml/min, 30–60 ml/min, ≤ 30 ml/min and hemodialysis-dependent. Tinzaparin 175 IU/kg was administered once daily for 5 days or until the INR was ≥ 2.0 with warfarin therapy. Trough anti-Xa levels were measured prior to the 3rd (day 3) and 5th (day 5) tinzaparin doses. Patients with an anti-Xa level > 0.5 IU/mL received tinzaparin dose adjustment using a standardized nomogram. Results: The relationship between anti-Xa levels and CrCl is shown in figure 1. One patient with a CrCl of 47 ml/min had a day 3 anti-Xa level of 0.62 IU/ml and required dose adjustment, resulting in a day 5 anti-Xa of 0.22 IU/ml. There has been one minor bleeding event (hematoma) following a traumatic intravenous catheter insertion. No major bleeding or recurrent VTE events have occurred. Conclusions: In a cohort of 32 patients with differing degrees of renal function including patients requiring hemodialysis, use of therapeutic-dose tinzaparin for 5 days does not appear to result in accumulation of the anticoagulant effects. There is no apparent correlation between anti-Xa level and renal function. Our results support ongoing evaluation of tinzaparin in patients with severe renal insufficiency. Figure 1. Anti-Xa levels an renal function Figure 1. Anti-Xa levels an renal function

Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats

2021 ◽  
pp. 019262332110453
Author(s):  
Rebecca Kohnken ◽  
Lauren Himmel ◽  
Michael Logan ◽  
Richard Peterson ◽  
Sabyasachi Biswas ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Injury ◽  
Periodic Acid ◽  
Kidney Tissue ◽  
Glomerular Injury ◽  
Symmetric Dimethylarginine ◽  
Puromycin Aminonucleoside ◽  
Periodic Acid Schiff ◽  
Gold Standard Method ◽  
Toxicity Studies

Glomerular filtration rate is the gold-standard method for assessment of renal function but is rarely performed in routine toxicity studies. Standard serum biomarkers of renal function are insensitive and become elevated only with significant loss of organ function. Symmetric dimethylarginine (SDMA) is a ubiquitous analyte that is freely filtered by the glomerulus and can be detected in serum. It has shown utility for the detection of renal injury in dogs and cats in clinical veterinary practice, but the potential utility of SDMA to detect renal injury in preclinical species or toxicity studies has not been thoroughly investigated. We utilized a well-characterized glomerular toxicant, puromycin aminonucleoside, to induce podocyte injury and subsequent proteinuria in young male Sprague-Dawley rats. At the end of 1 or 2 weeks, blood, urine, and kidney tissue were collected for analysis. One week following a single 50 mg/kg dose, urea nitrogen, creatinine, and albumin mean values were within historical control ranges, while SDMA was increased. Glomerular changes in these animals included periodic acid–Schiff positive globules within podocytes, podocyte hypertrophy by light microscopy, and podocyte degeneration with effacement of foot processes by electron microscopy (EM). Taken together, our data indicate that SDMA may be a useful biomarker for early detection of glomerular toxicities in rats.

scholarly journals Carbon nanotubes functionalized with sodium hyaluronate: Sterilization, osteogenic capacity and renal function analysis

Life Sciences ◽  
2020 ◽  
Vol 248 ◽  
pp. 117460 ◽  
Author(s):  
Tatiane Cristina Silva Almeida ◽  
Paulo Antônio Martins-Júnior ◽  
Julliane Vasconcellos Joviano-Santos ◽  
Vanessa Barbosa Andrade ◽  
Luiz Carlos Duarte Ladeira ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Renal Function ◽  
Function Analysis ◽  
Sodium Hyaluronate

Impact of Mycophenolate Mofetil Dose Posttransplantation on 12-Month Renal Function: Analysis of the MOST Database

2005 ◽  
Vol 37 (6) ◽  
pp. 2464-2466 ◽  
Author(s):  
M. Salvadori ◽  
A. Bock ◽  
J. Chapman ◽  
B. Dussol ◽  
L. Fritsche ◽  
...  
Keyword(s):  
Renal Function ◽  
Mycophenolate Mofetil ◽  
Function Analysis

scholarly journals Renal dysfunction among HIV patients under highly active antiretroviral therapy attending Kibagabaga district

2021 ◽  
pp. bs20212
Author(s):  
Munyandamutsa Fulgence ◽  
Mucumbitsi Joseph ◽  
Yadufashije Callixte ◽  
Niyonzima William
Keyword(s):  
Renal Function ◽  
Antiretroviral Therapy ◽  
Data Collection ◽  
Renal Dysfunction ◽  
Highly Active Antiretroviral Therapy ◽  
Function Analysis ◽  
Primary Data ◽  
Hiv Patients ◽  
Blood Samples ◽  
Highly Active

Antiretroviral therapy is used for the suppression of the HIV virus and stops its progression to cause disease. Despite its role, it has the pathophysiologic effect to kidney function for users. The study was conducted to evaluate the renal function for HIV patients under highly active antiretroviral therapy at Kibagabaga District Hospital. Venous blood samples (4mL) were collected by vein puncture in phlebotomy services by means of the dry tubes from 170 patients under antiretroviral therapy. Blood samples were transported to clinical biochemistry department for analysis. Rotor centrifuge was used to separate the serum and other blood components; creatinine level was analysed for renal function analysis. The total of 170 HIV patients were considered in the study. Of the 170, 50 HIV patients were used for primary data collection, while 120 HIV patients who previously received antiretroviral therapy were considered as secondary data collection source. The patients between 25-45 years old have experienced the highest level of abnormal concentration of renal tests 25%, patients with above 45 years old was ranked the second to have the abnormal level (14.2%). Females were 59% and have experienced the high risk of renal dysfunction than males, the level of glomerular filtration rate was 67 (39.4%), and was higher than creatinine 42 (24.7%). Antiretroviral therapy has a negative effect on kidneys. Abnormalities of the kidney parameters were prevalently high among both male and female. The serious follow is needed for this vulnerable population.

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