scholarly journals Polypoid cystitis as a cause of haematuria in a pony mare

2017 ◽  
Vol 31 (5) ◽  
pp. 250-254 ◽  
Author(s):  
C. M. Rosales ◽  
N. J. Bamford ◽  
S. L. Sullivan ◽  
J. R. Bauquier ◽  
B. S. Tennent‐Brown
Keyword(s):  
Polypoid Cystitis

Polypoid cystitis in a three year old child: does microbial inflammation play a role in the aetiology of this disease?

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S138
Author(s):  
Almustapha Aliyu Liman ◽  
Ahmed Mohammed ◽  
Sannom Yates ◽  
Ahmed Tijjani Lawal ◽  
Murtala Abubakar
Keyword(s):  
Polypoid Cystitis

scholarly journals Assessment of HER2 Expression in Canine Urothelial Carcinoma of the Urinary Bladder

2019 ◽  
Vol 56 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Masaya Tsuboi ◽  
Kosei Sakai ◽  
Shingo Maeda ◽  
James K. Chambers ◽  
Tomohiro Yonezawa ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Evaluation Method ◽  
Growth Factor Receptor ◽  
Her2 Expression ◽  
Clinical Factors ◽  
Normal Bladder ◽  
Cell Proliferation And Differentiation ◽  
Polypoid Cystitis ◽  
Her2 Positivity

Canine urothelial carcinoma (UC) has a poor prognosis and high metastatic rate. Human epidermal growth factor receptor 2 (HER2), a receptor tyrosine kinase involved in cell proliferation and differentiation regulation, has been attracting interest as a therapeutic target molecule for human breast cancer. This study investigated expression of the canine homolog of HER2 (ERBB2) in canine UC, and its association with clinical factors. Since it has been controversial whether commercial anti-human HER2 antibody (Dako A0485) correctly recognizes the canine homolog of HER2, an application of the antibody using a canine UC cell line was validated first. By Western blot, a single band at the appropriate size for canine HER2 (185 kDa) was recognized. Immunohistochemistry for HER2 was performed on 23 samples of UC, 8 samples of polypoid cystitis, and 8 samples of normal urinary bladder, and the results were scored as either 0, 1+, 2+, or 3+ with reference to the evaluation method for human UC. Intense membranous HER2 immunoreactivity was frequently observed in neoplastic cells, especially in grade 2 UC. Minor HER2 expression was found in the epithelial cells of polypoid cystitis and normal bladder. The incidence of HER2 positivity (scores of 2+ or 3+) was 14 of 23 (60.9%) in UC, 3 of 8 (37.5%) in polypoid cystitis, and 0 of 8 (0%) in normal bladder. There was no significant correlation between HER2 positivity and clinical factors. While increased HER2 expression was observed in a subset of urothelial carcinomas, further mechanistic studies are needed to determine its role in the pathogenesis and targeted therapy of this cancer.

scholarly journals Diagnostic Ultrasound of Polypoid Cystitis in Dogs

2005 ◽  
Vol 67 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Mitsuyoshi TAKIGUCHI ◽  
Mutsumi INABA
Keyword(s):  
Diagnostic Ultrasound ◽  
Polypoid Cystitis

Urinary Retention Due to Benign Tumor of the Bladder Neck in a Woman; A Rare Case of Papillary Cystitis

2013 ◽  
Vol 80 (1) ◽  
pp. 83-85 ◽  
Author(s):  
Kostantinos Stamatiou
Keyword(s):  
Urinary Retention ◽  
Bladder Neck ◽  
Transitional Cell ◽  
Pathological Examination ◽  
Tissue Mass ◽  
First Case ◽  
History Of ◽  
Carcinoma Of The Bladder ◽  
Papillary Cystitis ◽  
Polypoid Cystitis

Background Urinary retention (UR) is not common in women. There are numerous causes now recognized in women, broadly categorized as infective, pharmacological, neurological, anatomical, myopathic and functional. As opposed to the male, obstructive UR is unusual in women. Methods A 56-year-old woman presented with urinary retention. She reported difficulty in urination for more than 15 days. She had no history of urinary tract infection, bladder surgery and catheterization. Her physical examination revealed a soft tissue mass obstructing the external orifice of the urethra. After its partial removal the patient regained her ability to urinate. Results The patient underwent urological investigation. Ultrasound examination of the urinary system was normal. Cystoscopic examination revealed a papillary lesion with broad base floating along the bladder neck. The patient underwent transurethral resection of the bladder tumor. Discussion Pathological examination diagnosed papillary cystitis. She was scheduled for a regular follow-up with urine cytology, ultrasound and cystoscopy. One year after diagnosis the patient remains free of symptoms and no recurrence was observed. Conclusions Papillary and polypoid cystitis are benign lesions, however under certain circumstances they should be considered in the differential diagnosis of transitional cell carcinoma of the bladder. Lack of the prominent inflammation and edema that characterizes both papillary and polypoid cystitis, and absence of a history of recent bladder catheterization and presence of vesical fistula may facilitate the decision to biopsy the lesion. To our knowledge, this is the first case of papillary cystitis presenting with urinary retention in a woman to be reported in the literature.

scholarly journals ErbB2 Copy Number Aberration in Canine Urothelial Carcinoma Detected by a Digital Polymerase Chain Reaction Assay

2019 ◽  
Vol 57 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Kosei Sakai ◽  
Shingo Maeda ◽  
Kohei Saeki ◽  
Ryohei Yoshitake ◽  
Yuko Goto-Koshino ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Copy Number ◽  
Digital Pcr ◽  
Copy Number Aberration ◽  
Chromosome 8 ◽  
Pcr Assay ◽  
Formalin Fixed Paraffin Embedded ◽  
Polypoid Cystitis ◽  
Normal Controls

Urothelial carcinoma (UC) is the most common tumor affecting the urinary bladder of dogs. Protein overexpression of ErbB2 (the canine homolog of HER2) has been observed in dogs with UC. However, no study regarding ErbB2 copy number aberration (CNA) is reported in dogs with UC. In this study, a digital PCR assay for detecting CNA of canine ErbB2 was developed. DNA samples were isolated from 83 formalin-fixed, paraffin-embedded urinary bladder tissues (36 UC, 8 polypoid cystitis, and 39 normal) and 94 urinary sediments (54 UC, 30 nonneoplastic, and 10 normal). The copy number of canine chromosome 8 ( CFA8) was used as a control. In the urinary bladder tissues, ErbB2 CNA was detected in 12 of 36 (33%) UC, 2 of 8 (25%) polypoid cystitis, and 0 of 39 (0%) normal controls. In the urinary sediments, ErbB2 CNA was also detected in 19 of 54 (35%) UC; however, no ErbB2 CNA was detected in nonneoplastic diseases or normal controls. The sensitivity and specificity of ErbB2 CNA in urinary sediment for the detection of UC were 35% and 100%, respectively. There was a positive correlation between the copy number ratios of ErbB2 to CFA8 in the urinary bladder tissues and urinary sediments. Our findings indicate that the digital PCR assay of urinary sediments may be a useful, noninvasive method for detecting ErbB2 CNA in dogs with UC.

scholarly journals Simulators of Urothelial Carcinoma

2020 ◽  
Author(s):  
Claudia Manini ◽  
Javier C. Angulo ◽  
José I. López
Keyword(s):  
Spindle Cell ◽  
Squamous Metaplasia ◽  
Molecular Data ◽  
Nephrogenic Adenoma ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Xanthogranulomatous Inflammation ◽  
Post Radiation ◽  
The Right ◽  
Polypoid Cystitis

A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract. This narrative collects most of them from a clinical and pathologic perspective offering urologists and general pathologists their most salient definitory features. Together with classical, well-known, entities such as urothelial papillomas (conventional and inverted), nephrogenic adenoma, polypoid cystitis, fibroepithelial polyp, prostatic-type polyp, verumontanum cyst, xanthogranulomatous inflammation, reactive changes secondary to BCG instillations, schistosomiasis, keratinizing desquamative squamous metaplasia, post-radiation changes, vaginal-type metaplasia, endocervicosis/endometriosis (müllerianosis), malakoplakia, florid von Brunn nest proliferation, cystitis/ureteritis cystica and glandularis, among others, still other cellular proliferations with concerning histological features and poorly understood etiopathogenesis like IgG4-related disease, PEComa, and pseudosarcomatous myofibroblastic proliferations (post-operative spindle cell nodule, inflammatory myofibroblastic tumor), are reviewed. Some of these diagnoses are problematic for urologists, other for pathologists, and still others for both. Interestingly, the right identification of their definitory features will allow their correct diagnoses thus avoiding overtreatment. The literature selected for this review also focuses on the immunohistochemical and/or molecular data useful to delineate prognosis.

scholarly journals Polypoid Cystitis in 17 Dogs (1978-2001)

2003 ◽  
Vol 17 (4) ◽  
pp. 499-509 ◽  
Author(s):  
Ivan Martinez ◽  
John S. Mattoon ◽  
Kathryn A. Eaton ◽  
Dennis J. Chew ◽  
Stephen P. DiBartola
Keyword(s):  
Polypoid Cystitis
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