scholarly journals Impact at Human Scale

2020 ◽  
Vol 2020 (1) ◽  
pp. 298-298
Author(s):  
Nick Agafonoff ◽  
Lindsay Ferris ◽  
Tabitha Steager ◽  
Erin Taylor
Keyword(s):  
Human Scale

The Human Scale: A Note on Hard Times

1967 ◽  
Vol 22 (3) ◽  
pp. 288-293
Author(s):  
Ronald Berman
Keyword(s):  
Human Scale ◽  
Hard Times

scholarly journals Development of a Bioartificial Vascular Pancreas

2021 ◽  
Vol 12 ◽  
pp. 204173142110277
Author(s):  
Edward X Han ◽  
Juan Wang ◽  
Mehmet Kural ◽  
Bo Jiang ◽  
Katherine L Leiby ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pancreatic Islets ◽  
Vascular Graft ◽  
Term Treatment ◽  
Diffusion Limitations ◽  
Human Scale ◽  
Arterial Blood ◽  
Long Term Treatment

Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased dramatically, as in translating from rodent studies to human-scale treatments. To address these limitations, an islet transplantation approach using an acellular vascular graft as a vascular scaffold has been developed, termed the BioVascular Pancreas (BVP). To create the BVP, islets are seeded as an outer coating on the surface of an acellular vascular graft, using fibrin as a hydrogel carrier. The BVP can then be anastomosed as an arterial (or arteriovenous) graft, which allows fully oxygenated arterial blood with a pO2 of roughly 100 mmHg to flow through the graft lumen and thereby supply oxygen to the islets. In silico simulations and in vitro bioreactor experiments show that the BVP design provides adequate survivability for islets and helps avoid islet hypoxia. When implanted as end-to-end abdominal aorta grafts in nude rats, BVPs were able to restore near-normoglycemia durably for 90 days and developed robust microvascular infiltration from the host. Furthermore, pilot implantations in pigs were performed, which demonstrated the scalability of the technology. Given the potential benefits provided by the BVP, this tissue design may eventually serve as a solution for transplantation of pancreatic islets to treat or cure type 1 diabetes.

scholarly journals New Housing Developments in the City Center of Guadalajara (Mexico): An Analysis from the Perspective of Collective and Sustainable Dwelling

Buildings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 168
Author(s):  
Alessandra Cireddu
Keyword(s):  
Point Of View ◽  
City Center ◽  
Compact City ◽  
Housing Developments ◽  
Human Scale ◽  
Horizontal Growth ◽  
Downtown Redevelopment ◽  
Mode Of Transport ◽  
The City ◽  
New Buildings

New vertical housing developments in Guadalajara (Mexico) are reaching the city center as a response for redensification after many years of expansion of the urban area characterized by a suburban, low density and fragmented pattern. This horizontal growth, dominated by use of the automobile as prevailing mode of transport, has proven to be unsustainable not only from an environmental point of view, but also from a social perspective where the “human scale” of the city has been affected, same as the daily life of its inhabitants. On the other hand, vertical housing proposals are by their very nature associated with concepts of redensification, compact city and collective living; the aim of this article is to analyze some new housing developments in Guadalajara downtown in order to evaluate to what extent the new buildings embody a more sustainable, livable and collective dwelling, to discuss findings, successes and failures and thus be able to contribute some conclusions and open a broader reflection about contemporary housing, urban density and downtown redevelopment in Latin America cities through collective and sustainable dwelling.

Stabilizing control and human scale simulation of a submarine ROV navigation

2016 ◽  
Vol 114 ◽  
pp. 66-78 ◽  
Author(s):  
Adel Khadhraoui ◽  
Lotfi Beji ◽  
Samir Otmane ◽  
Azgal Abichou
Keyword(s):  
Human Scale ◽  
Stabilizing Control

scholarly journals Reconstructing Late Pleistocene paleoclimate at the scale of human behavior: an example from the Neandertal occupation of La Ferrassie (France)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sarah Pederzani ◽  
Vera Aldeias ◽  
Harold L. Dibble ◽  
Paul Goldberg ◽  
Jean-Jacques Hublin ◽  
...  
Keyword(s):  
Human Behavior ◽  
Late Pleistocene ◽  
Tooth Enamel ◽  
Climatic Conditions ◽  
Climatic Data ◽  
Human Scale ◽  
Winter Temperatures ◽  
Archaeological Materials ◽  
Climatic Records

AbstractExploring the role of changing climates in human evolution is currently impeded by a scarcity of climatic information at the same temporal scale as the human behaviors documented in archaeological sites. This is mainly caused by high uncertainties in the chronometric dates used to correlate long-term climatic records with archaeological deposits. One solution is to generate climatic data directly from archaeological materials representing human behavior. Here we use oxygen isotope measurements of Bos/Bison tooth enamel to reconstruct summer and winter temperatures in the Late Pleistocene when Neandertals were using the site of La Ferrassie. Our results indicate that, despite the generally cold conditions of the broader period and despite direct evidence for cold features in certain sediments at the site, Neandertals used the site predominantly when climatic conditions were mild, similar to conditions in modern day France. We suggest that due to millennial scale climate variability, the periods of human activity and their climatic characteristics may not be representative of average conditions inferred from chronological correlations with long-term climatic records. These results highlight the importance of using direct routes, such as the high-resolution archives in tooth enamel from anthropogenically accumulated faunal assemblages, to establish climatic conditions at a human scale.

Abstract 297: Paroxysmal And Sustained Atrial Fibrillation In A New Large Animal Model Of Nonischemic Heart Failure

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Saad Sikanderkhel ◽  
Olawale Onibile ◽  
Gregory P Walcott ◽  
Steven M Pogwizd
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Animal Model ◽  
Holter Monitoring ◽  
Aortic Insufficiency ◽  
Large Animal Model ◽  
Large Animal ◽  
Aortic Constriction ◽  
Holter Monitor ◽  
Human Scale

Introduction: Atrial fibrillation is common in heart failure (HF). Understanding of the mechanisms of atrial fibrillation (AF) is limited by the paucity of large animal AF models, especially in the failing heart. We developed a large animal model of nonischemic heart failure (HF) in dogs by combined aortic insufficiency and aortic constriction and observed that a number of HF dogs developed paroxysmal AF on holter monitor. Here we characterize the spontaneously-occurring pAF in these HF dogs and perform electrophysiologic (EP) assessment of atrial refractoriness and AF inducibility along with echocardiographic imaging of left ventricle (LV) and left atrium (LA). Methods: HF was induced in dogs by aortic insufficiency and aortic constriction, and serial echocardiography (for LV fractional shortening (FS) and LA size) and Holter monitoring was performed. In control and HF dogs, EP study of atrial refractory period (AERP) and AF inducibility (duration and atrial cycle length (CL)) was performed. Results: By Holter monitoring, paroxysmal AF was noted in 5 dogs with episodes ranging from 15 to 94 beats long (mean of 49±27 beats, n=12). In EP studies, control dogs (N=3) exhibited AERP of 176±8 ms. Burst pacing resulted in AF of very brief duration (mean 32±24 sec) and a mean AF CL of 138±6 ms. LV FS averaged 37% and LA size averaged 4.3 cm2. HF dogs (N=5) exhibited RAERP of 150±8 (p=0.05 vs control). Two of these dogs had sustained AF with ventricular response up to 230 bpm on Holter monitor. In the other 3 HF dogs, burst pacing induced AF with a mean duration of 232±185 sec (at times with conversion to atrial flutter) and with a mean AF CL = 110±4 ms (p=0.002 vs control). Echo data showed LVFS averaged 30% and LA area of 14.9 cm2 (p=0.05 vs control). Conclusion: Thus we have developed a novel large animal model of HF that exhibits paroxysmal and sustained AF. This model will provide an opportunity for the study of underlying AF mechanisms, the progression of remodeling in HF hearts leading to AF, and the assessment of human-scale interventions to better treat and prevent this arrhythmia.

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