Usefulness of the postkainate spontaneous recurrent seizure model for screening for antiseizure and neuroprotective effects

Epilepsia ◽  
2021 ◽  
Author(s):  
Mohamad A. Mikati ◽  
Gregory L. Holmes
Keyword(s):  
Neuroprotective Effects ◽  
Recurrent Seizure ◽  
Seizure Model ◽  
Spontaneous Recurrent Seizure

Spontaneous recurrent seizure following status epilepticus enhances dentate gyrus neurogenesis

2004 ◽  
Vol 26 (6) ◽  
pp. 394-397 ◽  
Author(s):  
Byung Ho Cha ◽  
Cigdem Akman ◽  
Diosely C. Silveira ◽  
Xianzeng Liu ◽  
Gregory L. Holmes
Keyword(s):  
Status Epilepticus ◽  
Dentate Gyrus ◽  
Recurrent Seizure ◽  
Spontaneous Recurrent Seizure

scholarly journals Effects of N(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in spontaneous recurrent seizure rats

2010 ◽  
Vol 4 (2) ◽  
pp. 271-279
Author(s):  
Onrawee Khongsombat ◽  
Boonyong Tantisira ◽  
Mayuree H. Tantisira
Keyword(s):  
Amino Acid ◽  
Parent Compound ◽  
Gamma Aminobutyric Acid ◽  
Amino Acid Neurotransmitters ◽  
Recurrent Seizure ◽  
Inhibitory Neurotransmitters ◽  
Spontaneous Recurrent Seizure ◽  
And Control ◽  
Human Temporal Lobe

Abstract Background: N(2-propylpentanoyl) urea (VPU) is a new valproic acid (VPA) analog with higher anticonvulsant activity than its parent compound in various animal models including seizure acutely induced by pilocarpine. Objective: Investigate its effects on hippocampal amino acid neurotransmitters in spontaneous recurrent seizure (SRS) rats. Methods: Pilocarpine hydrochloride was used to induce status epilepticus (SE). Animals were visually observed for two hours/day for an episode of SRS for six weeks. Microdialysis experiment was performed to detect hippocampal amino acid neurotransmitters on those rats that developed SRS. Results: In comparison to normal rats, hippocampal glutamate, gamma-aminobutyric acid (GABA), and glycine, significantly increased in SRS rats. Occurrence of SRS in the faces of increased level of inhibitory neurotransmitters suggests the key role played by glutamate in the genesis and control of SRS. Based on the observation in pilocarpine-induced SE, the level of glutamate in SRS rats significantly decreased by a clinically effective anticonvulsant, VPA (300 and 600 mg/kg, i.p). Similar profile on hippocampal glutamate was also exhibited by VPU (50 and 100 mg/kg, i.p.). Conclusion: The possible role of VPU in controlling seizure in SRS rats and subsequently human temporal lobe epilepsy as VPA was suggested.

scholarly journals A Spontaneous Recurrent Seizure Bioassay for Anti-Epileptogenic Molecules

2005 ◽  
Vol 32 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Angela P. Lyon ◽  
Dan Wainman ◽  
Sandra Marone ◽  
Donald F. Weaver
Keyword(s):  
Drug Design ◽  
Biological Model ◽  
Normal Brain ◽  
Maximal Electroshock ◽  
Recurrent Seizure ◽  
New Chemical Entities ◽  
Spontaneous Recurrent Seizure ◽  
New Compounds

Drug design in epilepsy is now tackling a new target - epileptogenesis. This is the process whereby a normal brain becomes susceptible to recurrent seizures. One of the stumbling blocks in the design and discovery of new chemical entities as antiepileptogenics is the implementation of an appropriate biological model. Current models, such as the maximal electroshock model, are models of seizures, not models of epileptogenesis. To develop such a model, we have extended and modified a chronic pilocarpine spontaneous recurrent seizure (SRS) model for the purposes of developing a bioassay with which to screen new compounds for putative antiepileptogenic bioactivity.

scholarly journals Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model

2015 ◽  
Vol 5 (10) ◽  
pp. 817-820 ◽  
Author(s):  
Humera Khatoon ◽  
Rahila Najam ◽  
Talat Mirza ◽  
Bushra Sikandar ◽  
Humera Ishaq ◽  
...  
Keyword(s):  
Camel Milk ◽  
Neuroprotective Effects ◽  
Seizure Model

scholarly journals Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Shuzhen Kong ◽  
Zhihua Cheng ◽  
Jianhui Liu ◽  
Yun Wang
Keyword(s):  
Animal Model ◽  
Epileptic Seizure ◽  
Hippocampal Neurons ◽  
Drug Testing ◽  
Anticonvulsant Drug ◽  
Recurrent Seizure ◽  
Receptor Inhibition ◽  
Gaba Synthesis ◽  
Freely Moving ◽  
Seizure Model

Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ induced seizure rats could develop to have recurrent seizure still remains unknown. In the current study, we demonstrated that 46% of the CTZ induced seizure rats developed to have recurrent seizure behavior as well as epileptic EEG with a starting latency between 2 weeks and several months. In those chronic seizure rats 6 months after the seizure induction by the CTZ, our immunohistochemistry results showed that both GAD and GAT-1 were significantly decreased across CA1, CA3, and dentate gyrus area of the hippocampus studied. In addition, both BDNF and its receptor TrkB were also decreased in hippocampus of the chronic CTZ seizure rats. Our results indicate that CTZ induced seizure is capable of developing to have recurrent seizure, and the decreased GABA synthesis and transport as well as the impaired BDNF-TrkB signaling pathway may contribute to the development of the recurrent seizure. Thus, CTZ seizure rats may provide a novel animal model for epilepsy study and anticonvulsant drug testing in the future.

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