Histopathologic subtype of hippocampal sclerosis and episodic memory performance before and after temporal lobectomy for epilepsy

Epilepsia ◽  
2018 ◽  
Vol 59 (4) ◽  
pp. 825-833 ◽  
Author(s):  
Shahram Saghafi ◽  
Lisa Ferguson ◽  
Olivia Hogue ◽  
Jordan M. Gales ◽  
Richard Prayson ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Hippocampal Sclerosis ◽  
Memory Performance ◽  
Temporal Lobectomy ◽  
Before And After

Memory Performance in Older Adults Before and After Temporal Lobectomy for Pharmacoresistant Epilepsy

2013 ◽  
Vol 27 (8) ◽  
pp. 1316-1327 ◽  
Author(s):  
Jessica S. Chapin ◽  
Robyn M. Busch ◽  
Diosely C. Silveira ◽  
Tim Wehner ◽  
Richard I. Naugle ◽  
...  
Keyword(s):  
Older Adults ◽  
Memory Performance ◽  
Temporal Lobectomy ◽  
Pharmacoresistant Epilepsy ◽  
Before And After

scholarly journals Age of seizure onset as a major determinant of memory changes following surgery for hippocampal sclerosis

2019 ◽  
Author(s):  
Eduardo Leal-Conceição ◽  
Marino Muxfeldt Bianchin ◽  
Wyllians Vendramini Borelli ◽  
Liss Januário de Oliveira ◽  
Mário Bernardes Wagner ◽  
...  
Keyword(s):  
Visual Memory ◽  
Age Of Onset ◽  
Hippocampal Sclerosis ◽  
Memory Performance ◽  
Mesial Temporal Lobe Epilepsy ◽  
Reliable Change Index ◽  
Control Group ◽  
Seizure Onset ◽  
Before And After ◽  
The Right

AbstractObjectiveTo study the relation of epileptological and surgical variables with post-operative memory performance, following surgery for refractory mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS).MethodsLogical memory (LM) and visual memory (VM) scores for immediate and late recall of 201 patients operated for MTLE/HS from 1996 to 2016 were reviewed. All patients were evaluated prior to surgery and reevaluated up until 5 years after the procedure. Scores were standardized to a control group of 54 healthy individuals matched for age and education. Patients were divided in two groups according to the hemisphere affected and scores for immediate and late recall were compared. Reliable Change Index (RCI) with a 90% confidence interval was performed to verify individual memory changes for each late LM (lLM) and late VM (lVM) score. A multiple linear regression was performed with the RCI using late recall scores of lLM and lVM and clinical variables.Results112 (56%) patients had left HS (lHS). The lHS group showed decreased immediate LM (iLM) scores before and after surgery (p<0.05), compared with rHS. The rHS group showed increased iLM scores post-operatively (p<0.05). RCI of the rHS group showed that 6 (7%) individuals had improved, 78 (87%) stabilized and 5 (6%) decresead in lLM scores, and for lVM 7 (8%) improved, 80 (89%) stabilized and 2 (3%) worsened (RCI> 1.645). RCI of the lHS group showed that 3 (3%) individuals had increased scores, 104 (93%) stabilized and 5 (4%) worsened for lLM, and for lVM 3 (3%) obtained improved scores, 103 (92%) stabilized and 6 (5%) decreased (RCI> 1.645). lHS and later age of onset of the first epileptic seizure were predictors of lLM loss (p<0.05).ConclusionLeft MTLE/HS and later age of seizure onset were predictive factors for worsening of lLM. No RCI predictors of post-op lVM performance were identified. We found a decreased baseline functioning of LM in the lHS group and improvement of LM in some patients who had resection of the right MTL. Patients of the rHS group had a higher percentage of reliable post-op improvement for both VM and LM scores.

Impact of Comorbid Depression on Serial Position Effects in Alzheimer’s Disease

GeroPsych ◽  
2014 ◽  
Vol 27 (4) ◽  
pp. 161-169 ◽  
Author(s):  
Nienke A. Hofrichter ◽  
Sandra Dick ◽  
Thomas G. Riemer ◽  
Carsten Schleussner ◽  
Monique Goerke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serial Position ◽  
Episodic Memory ◽  
Memory Performance ◽  
Memory Function ◽  
Word List ◽  
Position Effects ◽  
Serial Position Effects ◽  
List Memory

Hippocampal dysfunction and deficits in episodic memory have been reported for both Alzheimer’s disease (AD) and major depressive disorder (MDD). Primacy performance has been associated with hippocampus-dependent episodic memory, while recency may reflect working memory performance. In this study, serial position profiles were examined in a total of 73 patients with MDD, AD, both AD and MDD, and healthy controls (HC) by means of CERAD-NP word list memory. Primacy performance was most impaired in AD with comorbid MDD, followed by AD, MDD, and HC. Recency performance, on the other hand, was comparable across groups. These findings indicate that primacy in AD is impaired in the presence of comorbid MDD, suggesting additive performance decrements in this specific episodic memory function.

Knowledge is power: prior knowledge aids memory formation for both congruent and incongruent events, but in different ways.

2017 ◽  
Author(s):  
Andrea Greve ◽  
Elisa Cooper ◽  
Roni Tibon ◽  
Richard Henson
Keyword(s):  
Episodic Memory ◽  
Prior Knowledge ◽  
Memory Performance ◽  
Memory Formation ◽  
Memory Test ◽  
World Knowledge ◽  
Apparent Paradox ◽  
Power Prior

Events that conform to our expectations, i.e, are congruent with our world knowledge or schemas, are better remembered than unrelated events. Yet events that conflict with schemas can also be remembered better. We examined this apparent paradox in four experiments, in which schemas were established by training ordinal relationships between randomly-paired objects, while episodic memory was tested for the number of objects on each trial. Better memory was found for both congruent and incongruent trials, relative to unrelated trials, producing memory performance that was a “U-shaped” function of congruency. Furthermore, the incongruency advantage, but not congruency advantage, emerged even if the information probed by the memory test was irrelevant to the schema, while the congruency advantage, but not incongruency advantage, also emerged after initial encoding. Schemas therefore augment episodic memory in multiple ways, depending on the match between novel and existing information.

Long-term seizure outcomes after pediatric temporal lobectomy: does brain MRI lesion matter?

2019 ◽  
Vol 24 (2) ◽  
pp. 200-208
Author(s):  
Ravindra Arya ◽  
Francesco T. Mangano ◽  
Paul S. Horn ◽  
Sabrina K. Kaul ◽  
Serena K. Kaul ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Hippocampal Sclerosis ◽  
Brain Mri ◽  
Temporal Lobectomy ◽  
Seizure Freedom ◽  
Seizure Onset

OBJECTIVEThere is emerging data that adults with temporal lobe epilepsy (TLE) without a discrete lesion on brain MRI have surgical outcomes comparable to those with hippocampal sclerosis (HS). However, pediatric TLE is different from its adult counterpart. In this study, the authors investigated if the presence of a potentially epileptogenic lesion on presurgical brain MRI influences the long-term seizure outcomes after pediatric temporal lobectomy.METHODSChildren who underwent temporal lobectomy between 2007 and 2015 and had at least 1 year of seizure outcomes data were identified. These were classified into lesional and MRI-negative groups based on whether an epilepsy-protocol brain MRI showed a lesion sufficiently specific to guide surgical decisions. These patients were also categorized into pure TLE and temporal plus epilepsies based on the neurophysiological localization of the seizure-onset zone. Seizure outcomes at each follow-up visit were incorporated into a repeated-measures generalized linear mixed model (GLMM) with MRI status as a grouping variable. Clinical variables were incorporated into GLMM as covariates.RESULTSOne hundred nine patients (44 females) were included, aged 5 to 21 years, and were classified as lesional (73%), MRI negative (27%), pure TLE (56%), and temporal plus (44%). After a mean follow-up of 3.2 years (range 1.2–8.8 years), 66% of the patients were seizure free for ≥ 1 year at last follow-up. GLMM analysis revealed that lesional patients were more likely to be seizure free over the long term compared to MRI-negative patients for the overall cohort (OR 2.58, p < 0.0001) and for temporal plus epilepsies (OR 1.85, p = 0.0052). The effect of MRI lesion was not significant for pure TLE (OR 2.64, p = 0.0635). Concordance of ictal electroencephalography (OR 3.46, p < 0.0001), magnetoencephalography (OR 4.26, p < 0.0001), and later age of seizure onset (OR 1.05, p = 0.0091) were associated with a higher likelihood of seizure freedom. The most common histological findings included cortical dysplasia types 1B and 2A, HS (40% with dual pathology), and tuberous sclerosis.CONCLUSIONSA lesion on presurgical brain MRI is an important determinant of long-term seizure freedom after pediatric temporal lobectomy. Pediatric TLE is heterogeneous regarding etiologies and organization of seizure-onset zones with many patients qualifying for temporal plus nosology. The presence of an MRI lesion determined seizure outcomes in patients with temporal plus epilepsies. However, pure TLE had comparable surgical seizure outcomes for lesional and MRI-negative groups.

scholarly journals Stereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yi-He Wang ◽  
Si-Chang Chen ◽  
Peng-Hu Wei ◽  
Kun Yang ◽  
Xiao-Tong Fan ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Controlled Trial ◽  
Mesial Temporal Lobe Epilepsy ◽  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy ◽  
Radiofrequency Thermocoagulation ◽  
Mesial Temporal Lobe ◽  
Randomised Controlled

Abstract Introduction In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (STARTS). Mesial temporal lobe epilepsy (mTLE) is a classical subtype of temporal lobe epilepsy that often requires surgical intervention. Although anterior temporal lobectomy (ATL) remains the most popular treatment for mTLE, accumulating evidence has indicated that ATL can cause tetartanopia and memory impairments. Stereotactic EEG (SEEG)-guided radiofrequency thermocoagulation (RF-TC) is a non-invasive alternative associated with lower seizure freedom but greater preservation of neurological function. In the present study, we aim to compare the safety and efficacy of SEEG-guided RF-TC and classical ATL in the treatment of mTLE. Methods and analysis STARTS is a single-centre, two-arm, randomised controlled, parallel-group clinical trial. The study includes patients with typical mTLE over the age of 14 who have drug-resistant seizures for at least 2 years and have been determined via detailed evaluation to be surgical candidates prior to randomisation. The primary outcome measure is the cognitive function at the 1-year follow-up after treatment. Seizure outcomes, visual field abnormalities after surgery, quality of life, ancillary outcomes, and adverse events will also be evaluated at 1-year follow-up as secondary outcomes. Discussion SEEG-guided RF-TC for mTLE remains a controversial seizure outcome but has the advantage for cognitive and visual field protection. This is the first RCT studying cognitive outcomes and treatment results between SEEG-guided RF-TC and standard ATL for mTLE with hippocampal sclerosis. This study may provide higher levels of clinical evidence for the treatment of mTLE. Trial registration ClinicalTrials.gov NCT03941613. Registered on May 8, 2019. The STARTS protocol has been registered on the US National Institutes of Health. The status of the STARTS was recruiting and the estimated study completion date was December 31, 2021.

scholarly journals Bi-Temporal Anodal Transcranial Direct Current Stimulation during Slow-Wave Sleep Boosts Slow-Wave Density but Not Memory Consolidation

2021 ◽  
Vol 11 (4) ◽  
pp. 410
Author(s):  
Simon Ruch ◽  
Kristoffer Fehér ◽  
Stephanie Homan ◽  
Yosuke Morishima ◽  
Sarah Maria Mueller ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Slow Wave ◽  
Direct Current ◽  
Memory Consolidation ◽  
Transcranial Direct Current Stimulation ◽  
Slow Wave Sleep ◽  
Memory Performance ◽  
Direct Current Stimulation ◽  
Sleep Parameters ◽  
Episodic Memories

Slow-wave sleep (SWS) has been shown to promote long-term consolidation of episodic memories in hippocampo–neocortical networks. Previous research has aimed to modulate cortical sleep slow-waves and spindles to facilitate episodic memory consolidation. Here, we instead aimed to modulate hippocampal activity during slow-wave sleep using transcranial direct current stimulation in 18 healthy humans. A pair-associate episodic memory task was used to evaluate sleep-dependent memory consolidation with face–occupation stimuli. Pre- and post-nap retrieval was assessed as a measure of memory performance. Anodal stimulation with 2 mA was applied bilaterally over the lateral temporal cortex, motivated by its particularly extensive connections to the hippocampus. The participants slept in a magnetic resonance (MR)-simulator during the recordings to test the feasibility for a future MR-study. We used a sham-controlled, double-blind, counterbalanced randomized, within-subject crossover design. We show that stimulation vs. sham significantly increased slow-wave density and the temporal coupling of fast spindles and slow-waves. While retention of episodic memories across sleep was not affected across the entire sample of participants, it was impaired in participants with below-average pre-sleep memory performance. Hence, bi-temporal anodal direct current stimulation applied during sleep enhanced sleep parameters that are typically involved in memory consolidation, but it failed to improve memory consolidation and even tended to impair consolidation in poor learners. These findings suggest that artificially enhancing memory-related sleep parameters to improve memory consolidation can actually backfire in those participants who are in most need of memory improvement.

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