scholarly journals Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy

Epilepsia ◽  
2017 ◽  
Vol 59 (2) ◽  
pp. 358-368 ◽  
Author(s):  
Stephanie L. Vanhoof-Villalba ◽  
Nicole M. Gautier ◽  
Vikas Mishra ◽  
Edward Glasscock
Keyword(s):  
Mouse Models ◽  
Channel Activation ◽  
Models Of Epilepsy

scholarly journals LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy

2014 ◽  
Vol 25 (9) ◽  
pp. 2729-2740 ◽  
Author(s):  
Francesco Rusconi ◽  
Leda Paganini ◽  
Daniela Braida ◽  
Luisa Ponzoni ◽  
Emanuela Toffolo ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Mouse Models ◽  
Neuronal Excitability ◽  
Models Of Epilepsy

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

2019 ◽  
Vol 62 (21) ◽  
pp. 9618-9641 ◽  
Author(s):  
Thilo Focken ◽  
Kristen Burford ◽  
Michael E. Grimwood ◽  
Alla Zenova ◽  
Jean-Christophe Andrez ◽  
...  
Keyword(s):  
Mouse Models ◽  
Models Of Epilepsy

scholarly journals The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease

2013 ◽  
Vol 15 (4) ◽  
pp. 405-421 ◽  
Author(s):  
Rick Shin ◽  
Katsunori Kobayashi ◽  
Hideo Hagihara ◽  
Jeffrey H Kogan ◽  
Shinichi Miyake ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Mouse Models ◽  
Psychiatric Disease ◽  
Models Of Epilepsy

scholarly journals Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy

Neuroscience ◽  
2014 ◽  
Vol 259 ◽  
pp. 142-154 ◽  
Author(s):  
J.J. Rahn ◽  
J.E. Bestman ◽  
B.J. Josey ◽  
E.S. Inks ◽  
K.D. Stackley ◽  
...  
Keyword(s):  
Mouse Models ◽  
Vitamin K ◽  
Models Of Epilepsy

Detection of spontaneous seizures in EEGs in multiple experimental mouse models of epilepsy

2021 ◽  
Author(s):  
Lan Wei ◽  
Halima Boutouil ◽  
Rogerio R Gerbatin ◽  
Omar Mamad ◽  
Mona Heiland ◽  
...  
Keyword(s):  
Mouse Models ◽  
Spontaneous Seizures ◽  
Experimental Mouse ◽  
Models Of Epilepsy

scholarly journals Interactive automated tool for reliable seizure detection in rat and mouse models of epilepsy

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S522
Author(s):  
Armen Sargsyan ◽  
Pablo Casillas-Espinosa ◽  
Wayne Frankel ◽  
Dmitri Melkonian ◽  
Terence O’Brien
Keyword(s):  
Mouse Models ◽  
Seizure Detection ◽  
Automated Tool ◽  
Models Of Epilepsy

Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy

2020 ◽  
Vol 319 (3) ◽  
pp. C605-C610
Author(s):  
Mei Liu ◽  
Lijuan Jiang ◽  
Min Wen ◽  
Yue Ke ◽  
Xiangzhen Tong ◽  
...  
Keyword(s):  
Mouse Models ◽  
Neuronal Excitability ◽  
Neuronal Degeneration ◽  
Epileptic Seizures ◽  
Gabaergic Neurons ◽  
Seizure Severity ◽  
Neuronal Excitation ◽  
Acute Seizures ◽  
Models Of Epilepsy

Epileptic seizures are the manifestation of hypersynchronous and excessive neuronal excitation. While the glutamatergic and GABAergic neurons play major roles in shaping fast neuronal excitation/inhibition homeostasis, it is well illustrated that astrocytes profoundly regulate neuronal excitation by controlling glutamate, GABA, cannabinoids, adenosine, and concentration of K+ around neurons. However, little is known about whether microglia take part in the regulation of acute neuronal excitation and ongoing epileptic behaviors. We proposed that if microglia are innately ready to respond to epileptic overexcitation, depletion of microglia might alter neuronal excitability and severity of acute epileptic seizures. We found that microglia depletion by plx3397, an inhibitor of CSF1R, exacerbates seizure severity and excitotoxicity-induced neuronal degeneration, indicating that microglia are rapidly responsive to the change of excitation/inhibition homeostasis and participate in the protection of neurons from overexcitation.

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