scholarly journals The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease

2013 ◽  
Vol 15 (4) ◽  
pp. 405-421 ◽  
Author(s):  
Rick Shin ◽  
Katsunori Kobayashi ◽  
Hideo Hagihara ◽  
Jeffrey H Kogan ◽  
Shinichi Miyake ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Mouse Models ◽  
Psychiatric Disease ◽  
Models Of Epilepsy

scholarly journals LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy

2014 ◽  
Vol 25 (9) ◽  
pp. 2729-2740 ◽  
Author(s):  
Francesco Rusconi ◽  
Leda Paganini ◽  
Daniela Braida ◽  
Luisa Ponzoni ◽  
Emanuela Toffolo ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Mouse Models ◽  
Neuronal Excitability ◽  
Models Of Epilepsy

scholarly journals Analysis of Differentially Expressed Genes in the Dentate Gyrus and Anterior Cingulate Cortex in a Mouse Model of Depression

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Yicong Wei ◽  
Keming Qi ◽  
Yi Yu ◽  
Wei Lu ◽  
Wei Xu ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Anterior Cingulate Cortex ◽  
Differentially Expressed Genes ◽  
Visual Learning ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Differentially Expressed ◽  
Psychiatric Disease ◽  
Mild Stress ◽  
Hub Genes

Major depressive disorder (MDD) is a prevalent, chronic, and relapse-prone psychiatric disease. However, the intermediate molecules resulting from stress and neurological impairment in different brain regions are still unclear. To clarify the pathological changes in the dentate gyrus (DG) and anterior cingulate cortex (ACC) regions of the MDD brain, which are the most closely related to the disease, we investigated the published microarray profile dataset GSE84183 to identify unpredictable chronic mild stress- (UCMS-) induced differentially expressed genes (DEGs) in the DG and ACC regions. Based on the DEG data, functional annotation, protein-protein interaction, and transcription factor (TF) analyses were performed. In this study, 1071 DEGs (679 upregulated and 392 downregulated) and 410 DEGs (222 upregulated and 188 downregulated) were identified in DG and ACC, respectively. The pathways and GO terms enriched by the DEGs in the DG, such as cell adhesion, proteolysis, ion transport, transmembrane transport, chemical synaptic transmission, immune system processes, response to lipopolysaccharide, and nervous system development, may reveal the molecular mechanism of MDD. However, the DEGs in the ACC involved metabolic processes, proteolysis, visual learning, DNA methylation, innate immune responses, cell migration, and circadian rhythm. Sixteen hub genes in the DG (Fn1, Col1a1, Anxa1, Penk, Ptgs2, Cdh1, Timp1, Vim, Rpl30, Rps21, Dntt, Ptk2b, Jun, Avp, Slit1, and Sema5a) were identified. Eight hub genes in the ACC (Prkcg, Grin1, Syngap1, Rrp9, Grwd1, Pik3r1, Hnrnpc, and Prpf40a) were identified. In addition, eleven TFs (Chd2, Zmiz1, Myb, Etv4, Rela, Tcf4, Tcf12, Chd1, Mef2a, Ubtf, and Mxi1) were predicted to regulate more than two of these hub genes. The expression levels of ten randomly selected hub genes that were specifically differentially expressed in the MDD-like animal model were verified in the corresponding regions in the human brain. These hub genes and TFs may be regarded as potential targets for future MDD treatment strategies, thus aiding in the development of new therapeutic approaches to MDD.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

2019 ◽  
Vol 62 (21) ◽  
pp. 9618-9641 ◽  
Author(s):  
Thilo Focken ◽  
Kristen Burford ◽  
Michael E. Grimwood ◽  
Alla Zenova ◽  
Jean-Christophe Andrez ◽  
...  
Keyword(s):  
Mouse Models ◽  
Models Of Epilepsy

scholarly journals Altered synaptic scaling of PV+ interneurons underlying sensorimotor gating deficit in psychiatric disease mouse models

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S270
Author(s):  
Jae Jin Shin ◽  
Sooyong Kim ◽  
Hwayoung Lee ◽  
Sangyoung Lee ◽  
Joomin Park ◽  
...  
Keyword(s):  
Mouse Models ◽  
Sensorimotor Gating ◽  
Psychiatric Disease ◽  
Synaptic Scaling

Social Endophenotypes in Mouse Models of Psychiatric Disease

2016 ◽  
pp. 231-264
Author(s):  
Marc T. Pisansky ◽  
Irving I. Gottesman ◽  
Jonathan C. Gewirtz
Keyword(s):  
Mouse Models ◽  
Psychiatric Disease

scholarly journals Enhancement of Progenitor Cell Division in the Dentate Gyrus Triggered by Initial Limbic Seizures in Rat Models of Epilepsy

Epilepsia ◽  
2000 ◽  
Vol 41 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Eiji Nakagawa ◽  
Yoshinari Aimi ◽  
Osamu Yasuhara ◽  
Ikuo Tooyama ◽  
Morimi Shimada ◽  
...  
Keyword(s):  
Cell Division ◽  
Dentate Gyrus ◽  
Progenitor Cell ◽  
Limbic Seizures ◽  
Rat Models ◽  
Models Of Epilepsy
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