scholarly journals Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xenia Kobeleva ◽  
Judith Machts ◽  
Maria Veit ◽  
Stefan Vielhaber ◽  
Susanne Petri ◽  
...  
Keyword(s):  
Working Memory ◽  
Amyotrophic Lateral Sclerosis ◽  
Brain Activity ◽  
Verbal Working Memory ◽  
Neuropsychological Function ◽  
Fmri Study ◽  
Lateral Sclerosis

scholarly journals Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xenia Kobeleva ◽  
Judith Machts ◽  
Maria Veit ◽  
Stefan Vielhaber ◽  
Susanne Petri ◽  
...  
Keyword(s):  
Working Memory ◽  
Amyotrophic Lateral Sclerosis ◽  
Functional Neuroimaging ◽  
Current Knowledge ◽  
Brain Activity ◽  
Reaction Times ◽  
Verbal Working Memory ◽  
Research Field ◽  
Fmri Study ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that causes progressive degeneration of neurons in motor and non-motor regions, affecting multiple cognitive domains. In order to contribute to the growing research field that employs structural and functional neuroimaging to investigate the effect of ALS on different working memory components, we conducted a functional magnetic resonance imaging (fMRI) study exploring the localization and intensity of alterations in neural activity. Being the first study to specifically address verbal working memory via fMRI in the context of ALS, we employed the verbal n-back task with 0-back and 2-back conditions. Despite ALS patients showing unimpaired accuracies and reaction times, there was significantly increased brain activity of frontotemporal and parietal regions in the 2-back minus 0-back contrast in patients compared to controls. This increased brain activity was largely associated with a better neuropsychological performance within the ALS group, suggesting a compensatory effect. This study therefore adds to the current knowledge on neural correlates of working memory in ALS and contributes to a more nuanced understanding of hyperactivity during cognitive processes in fMRI studies of ALS.

scholarly journals Patterns of Spontaneous Brain Activity in Amyotrophic Lateral Sclerosis: A Resting-State fMRI Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45470 ◽  
Author(s):  
ChunYan Luo ◽  
Qin Chen ◽  
Rui Huang ◽  
XuePing Chen ◽  
Ke Chen ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Resting State ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Spontaneous Brain Activity ◽  
Fmri Study ◽  
Lateral Sclerosis

Difference in cortical activity of lumbar- and bulbar-form of Amyotrophic lateral sclerosis: an fMRI study

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
K Kollewe ◽  
K Krampfl ◽  
A Samii ◽  
R Dengler ◽  
T Münte ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cortical Activity ◽  
Fmri Study ◽  
Lateral Sclerosis

Effects of Aquatic Motor Intervention on Verbal Working Memory and Brain Activity-A Pilot Study

2018 ◽  
Vol 12 (2) ◽  
pp. 90-99 ◽  
Author(s):  
Michal Nissim ◽  
Ronit Ram-Tsur ◽  
Joseph Glicksohn ◽  
Michal Zion ◽  
Zemira Mevarech ◽  
...  
Keyword(s):  
Working Memory ◽  
Pilot Study ◽  
Brain Activity ◽  
Verbal Working Memory

Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study

NeuroImage ◽  
2003 ◽  
Vol 19 (4) ◽  
pp. 1510-1520 ◽  
Author(s):  
John E Desmond ◽  
S.H.Annabel Chen ◽  
Eve DeRosa ◽  
Michelle R Pryor ◽  
Adolf Pfefferbaum ◽  
...  
Keyword(s):  
Working Memory ◽  
Verbal Working Memory ◽  
Fmri Study

scholarly journals An fMRI Study of Functional Abnormalities in the Verbal Working Memory System and the Relationship to Clinical Symptoms in Chronic Schizophrenia

2009 ◽  
Vol 20 (1) ◽  
pp. 46-60 ◽  
Author(s):  
Ryu-ichiro Hashimoto ◽  
KangUk Lee ◽  
Alexander Preus ◽  
Robert W. McCarley ◽  
Cynthia G. Wible
Keyword(s):  
Working Memory ◽  
Clinical Symptoms ◽  
Verbal Working Memory ◽  
Chronic Schizophrenia ◽  
Memory System ◽  
Fmri Study ◽  
The Relationship

A neurophysiological analysis of working memory in amyotrophic lateral sclerosis

2011 ◽  
Vol 1421 ◽  
pp. 90-99 ◽  
Author(s):  
Anke Hammer ◽  
Stefan Vielhaber ◽  
Antoni Rodriguez-Fornells ◽  
Bahram Mohammadi ◽  
Thomas F. Münte
Keyword(s):  
Working Memory ◽  
Amyotrophic Lateral Sclerosis ◽  
Lateral Sclerosis

scholarly journals Acute Ketamine Administration Alters the Brain Responses to Executive Demands in a Verbal Working Memory Task: an fMRI Study

2004 ◽  
Vol 29 (6) ◽  
pp. 1203-1214 ◽  
Author(s):  
R A E Honey ◽  
G D Honey ◽  
C O'Loughlin ◽  
S R Sharar ◽  
D Kumaran ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Task ◽  
Verbal Working Memory ◽  
Brain Responses ◽  
Fmri Study ◽  
The Brain
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