Serum high‐molecular‐weight adiponectin level and incident dementia in patients with vascular risk factors

2015 ◽  
Vol 23 (3) ◽  
pp. 641-647 ◽  
Author(s):  
K. Kitagawa ◽  
K. Miwa ◽  
S. Okazaki ◽  
M. Sakaguchi ◽  
H. Mochizuki
Keyword(s):  
Risk Factors ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Adiponectin Level ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
High Molecular Weight Adiponectin ◽  
Incident Dementia

scholarly journals Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome

2016 ◽  
Vol 63 (7) ◽  
pp. 655-662 ◽  
Author(s):  
Guoyue Yuan ◽  
Weiyun Qian ◽  
Ruirong Pan ◽  
Jue Jia ◽  
Dan Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
High Molecular Weight Adiponectin

scholarly journals Lower ratio of high-molecular-weight adiponectin level to total may be associated with coronary high-risk plaque

2013 ◽  
Vol 6 (1) ◽  
pp. 83 ◽  
Author(s):  
Masao Moroi ◽  
Shamima Akter ◽  
Ryo Nakazato ◽  
Taeko Kunimasa ◽  
Hirofumi Masai ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Risk ◽  
High Molecular Weight ◽  
Adiponectin Level ◽  
High Molecular Weight Adiponectin ◽  
Lower Ratio

Association between carotid stenosis or lacunar infarction and incident dementia in patients with vascular risk factors

2014 ◽  
Vol 22 (1) ◽  
pp. 187-192 ◽  
Author(s):  
K. Kitagawa ◽  
K. Miwa ◽  
Y. Yagita ◽  
S. Okazaki ◽  
M. Sakaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carotid Stenosis ◽  
Vascular Risk Factors ◽  
Lacunar Infarction ◽  
Vascular Risk ◽  
Incident Dementia

Abstract 98: Midlife Vascular Risk Factors and Incident Dementia in the ARIC Cohort

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Rebecca F Gottesman ◽  
Marilyn Albert ◽  
Laura Coker ◽  
Josef Coresh ◽  
Sonia M Davis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Status ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Atherosclerosis Risk In Communities ◽  
Black And White ◽  
Apoe Ε4 ◽  
Phone Calls ◽  
Incident Dementia ◽  
Increased Risk

Background: Vascular risk factors have been associated with risk of cognitive decline, with increasing evidence that midlife exposure to these risk factors may be most important in conferring late-life risk of cognitive impairment. We explored associations between vascular risk factors measured in midlife and the development of dementia over 25 years in the biracial Atherosclerosis Risk in Communities (ARIC) cohort. Methods: Participants in the ARIC study were recruited from four U.S. communities in 1987-1989, at ages 45-64, with four additional in-person visits, surveillance for hospitalizations, annual phone calls, and repeated cognitive evaluations over a 25-year period. In 2011-2013, ARIC participants were seen for the ARIC Neurocognitive Study (ARIC-NCS), and underwent a detailed neurocognitive battery and informant interviews. Through adjudicated review, dementia cases were defined. Additional dementia cases were identified through the telephone interview for cognitive status (TICS) or informant interview for those participants not attending ARIC-NCS; or by a prior dementia ICD-9 code during a hospitalization. Results: Of 15,744 participants in the cohort, 1516 cases of dementia were identified, of whom over one third were among black participants. Risk of dementia was highest in individuals of black race, with less than a high school education, older age, APOE ε4 carriage, and who, at ARIC baseline, had hypertension, diabetes, or were current smokers (table). APOE ε4 and smoking were each stronger risk factors for dementia in whites than in blacks. Discussion: Vascular risk factors measured in midlife are associated with increased risk of dementia in this biracial cohort, in black and white participants. The risk associated with diabetes nears the increased risk associated with having an APOE ε4 allele. Further studies are needed to evaluate the mechanism of and opportunities for prevention of the cognitive sequelae of these risk factors in midlife.

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