Association between carotid stenosis or lacunar infarction and incident dementia in patients with vascular risk factors

2014 ◽  
Vol 22 (1) ◽  
pp. 187-192 ◽  
Author(s):  
K. Kitagawa ◽  
K. Miwa ◽  
Y. Yagita ◽  
S. Okazaki ◽  
M. Sakaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carotid Stenosis ◽  
Vascular Risk Factors ◽  
Lacunar Infarction ◽  
Vascular Risk ◽  
Incident Dementia

scholarly journals Mitigating the effects of COVID-19 pandemic on controlling vascular risk factors among participants in a carotid stenosis trial

2020 ◽  
Vol 29 (12) ◽  
pp. 105362
Author(s):  
Tanya N. Turan ◽  
James F. Meschia ◽  
Marc I. Chimowitz ◽  
Ana Roldan ◽  
Todd LeMatty ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carotid Stenosis ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Markers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin and vascular risk factors in patients with carotid stenosis

2021 ◽  
pp. 16-21
Author(s):  
Olga Dubenko ◽  
Victoria Anysienkova
Keyword(s):  
Risk Factors ◽  
Serum Level ◽  
Phospholipase A2 ◽  
Carotid Endarterectomy ◽  
Carotid Stenosis ◽  
Vascular Risk Factors ◽  
Control Group ◽  
Vascular Risk ◽  
Stroke Risk Factor ◽  
Atherosclerotic Stenosis

The aim of this study is to evaluate serum level biomarkers of atherosclerosis lipoprotein-associated phospholipase A2 and E-selectin in patients with atherosclerotic carotid stenosis with different clinical manifestation in associated with vascular risk factors. Materials and methods: A total 106 patients with atherosclerotic carotid stenosis (74 men and 32 women, aged from 31 to 74 years, mean 62.6±0.9) were included: with acute ipsilateral atherothrombotic stroke (35), history of stroke and carotid endarterectomy (41) and 30 patients with asymptomatic carotid stenosis. The control group consist of 20 health subjects without cardiovascular disease. All participants underwent duplex sonography. Lipoprotein-associated phospholipase A2 and E-selectin was measured using commercially available (ELISA) kit. Results: The level of lipoprotein-associated phospholipase A2 was in general 55.664±3.537 ng/ml, which was significantly higher (M-W U=10, p=1.023136´10-11 <0.05) than in the control group (9.296±0.935 ng/ml). Level was significantly higher in groups of symptomatic patients who underwent carotid endarterectomy (p=0.04893), and proportion patients with high degree stenosis >70 % was greater in this group. The level of E-selectin in the study patients was significantly higher (7.653±0.246 pg/ml) than in the control group (3.101±0.503 pg/ml) p<0.05. No association the serum level of lipoprotein-associated phospholipase A2 and E-selectin with common stroke risk factor such as hypercholesterinemia, smoking and body mass index were found, but positive correlation of lipoprotein-associated phospholipase A2 with E-selectin was significant (p=0.00085). Conclusions: Increasing plasma level lipoprotein-associated phospholipase A2 and E-selectin in patients with the carotid atherosclerotic stenosis were observe. Statistically significant correlation between the level of lipoprotein-associated phospholipase A2 and E-selectin were found in symptomatic carotid atherosclerotic stenosis

Abstract 98: Midlife Vascular Risk Factors and Incident Dementia in the ARIC Cohort

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Rebecca F Gottesman ◽  
Marilyn Albert ◽  
Laura Coker ◽  
Josef Coresh ◽  
Sonia M Davis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Status ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Atherosclerosis Risk In Communities ◽  
Black And White ◽  
Apoe Ε4 ◽  
Phone Calls ◽  
Incident Dementia ◽  
Increased Risk

Background: Vascular risk factors have been associated with risk of cognitive decline, with increasing evidence that midlife exposure to these risk factors may be most important in conferring late-life risk of cognitive impairment. We explored associations between vascular risk factors measured in midlife and the development of dementia over 25 years in the biracial Atherosclerosis Risk in Communities (ARIC) cohort. Methods: Participants in the ARIC study were recruited from four U.S. communities in 1987-1989, at ages 45-64, with four additional in-person visits, surveillance for hospitalizations, annual phone calls, and repeated cognitive evaluations over a 25-year period. In 2011-2013, ARIC participants were seen for the ARIC Neurocognitive Study (ARIC-NCS), and underwent a detailed neurocognitive battery and informant interviews. Through adjudicated review, dementia cases were defined. Additional dementia cases were identified through the telephone interview for cognitive status (TICS) or informant interview for those participants not attending ARIC-NCS; or by a prior dementia ICD-9 code during a hospitalization. Results: Of 15,744 participants in the cohort, 1516 cases of dementia were identified, of whom over one third were among black participants. Risk of dementia was highest in individuals of black race, with less than a high school education, older age, APOE ε4 carriage, and who, at ARIC baseline, had hypertension, diabetes, or were current smokers (table). APOE ε4 and smoking were each stronger risk factors for dementia in whites than in blacks. Discussion: Vascular risk factors measured in midlife are associated with increased risk of dementia in this biracial cohort, in black and white participants. The risk associated with diabetes nears the increased risk associated with having an APOE ε4 allele. Further studies are needed to evaluate the mechanism of and opportunities for prevention of the cognitive sequelae of these risk factors in midlife.

scholarly journals Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

2017 ◽  
Vol 74 (10) ◽  
pp. 1246 ◽  
Author(s):  
Rebecca F. Gottesman ◽  
Marilyn S. Albert ◽  
Alvaro Alonso ◽  
Laura H. Coker ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Atherosclerosis Risk In Communities ◽  
Incident Dementia ◽  
Atherosclerosis Risk

Abstract 169: Circulating Il-6 And Il-18 Levels Are Associated With The Risk Of Incident Dementia In Patients With Vascular Risk Factors

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Kaori Miwa ◽  
Makiko Tanaka ◽  
Shuhei Okazaki ◽  
Shigetaka Furukado ◽  
Manabu Sakaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Atrophy ◽  
Inflammatory Markers ◽  
Brain Mri ◽  
Vascular Risk Factors ◽  
White Matter Hyperintensity ◽  
Vascular Risk ◽  
Mri Findings ◽  
Apoe4 Allele ◽  
Incident Dementia

Background and Purpose: Association between circulating inflammatory marker and future dementia has not been fully investigated. To what extent inflammatory markers impact future dementia beyond small vessel disease (SVD) and brain atrophy on MRI is unknown. We sought to determine the predictive value of circulating inflammation marker (high-sensitivity C-reactive protein [hsCRP], interleukin [IL]-6, and IL-18), when controlling for MRI measures of SVD (lacunar, white matter hyperintensity [WMH]) and brain atrophy on the risk of dementia. Methods: We enrolled 480 outpatients (median 68 years, male 58%, 12.8±2.4 years of schooling ) who had vascular risk factors but without dementia. At baseline, demographic information, brain MRI, and cognitive function testing were performed. We also measured hsCRP, IL-6, and IL-18. Baseline MRI was used to determine SVD (lacunar and WMH) and atrophy (cortical and subcortical). Cox proportional hazards analysis was performed as predictors of dementia with adjusting for age, gender, APOE4 allele, educational level, history of clinical stroke, conventional vascular risk factors, baseline Mini-Mental State Examination score and MRI-findings. Results: At end of follow-up (median 7.5 years duration), 40 patients had dementia (Alzheimer disease:21 patients, vascular dementia:16 patients, other type dementia:3 patients) In the age, gender, education level, and APOE4 allele-adjusted models, WMH severity, number of lacunar, atrophy, previous stroke, smoking and baseline MMSE-score were associated with incident dementia. Among inflammatory markers, both IL-6 and IL-18, but not hsCRP, were associated with dementia (IL-6; HR:2.10, 95% CI [1.21-3.58], IL-18; HR:3.32, 95% CI [1.52 -7.28], hsCRP; HR:1.08, 95% CI [0.80-1.46]) (per 1-SD increase in log-transformed inflammatory markers). These associations of both IL-6 and IL-18 with dementia remained significant even after additional adjusting for MRI-findings and confounding variables Conclusion: Our longitudinal study showed that both IL-6 and IL-18 levels are independently related to the risk of dementia in patients with vascular risk factors. Our results support the hypothesis that inflammation exerts deleterious effects on dementia incidence.

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