Encapsulation of young donor age dopaminergic grafts in a GDNF ‐loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi‐Parkinsonian rats

2019 ◽  
Vol 49 (4) ◽  
pp. 487-496 ◽  
Author(s):  
Niamh Moriarty ◽  
Sílvia Cabré ◽  
Verónica Alamilla ◽  
Abhay Pandit ◽  
Eilís Dowd
Keyword(s):  
Donor Age ◽  
Young Donor ◽  
Collagen Hydrogel ◽  
Dopaminergic Grafts

Improved survival of young donor age dopamine grafts in a rat model of Parkinson’s disease

Neuroscience ◽  
2007 ◽  
Vol 146 (4) ◽  
pp. 1606-1617 ◽  
Author(s):  
E.M. Torres ◽  
C. Monville ◽  
M.A. Gates ◽  
V. Bagga ◽  
S.B. Dunnett
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Donor Age ◽  
Young Donor

scholarly journals P1716MULTI-NATIONAL SURVEY AMONG NEPHROLOGISTS & TRANSPLANT SURGEONS ABOUT THE SUITABILITY & ACCEPTANCE OF MARGINAL LIVE KIDNEY DONORS REGARDING AGE DISCREPANCY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ziad Arabi ◽  
Kaysi Saleh ◽  
Abdullah Hamad ◽  
Mohammad Bukhari ◽  
Atif Mateen ◽  
...  
Keyword(s):  
Waiting Time ◽  
Deceased Donor ◽  
Donor Age ◽  
Cross Sectional Survey ◽  
Kidney Donors ◽  
Young Donor ◽  
Alternative Donor ◽  
Old Donor ◽  
The Impact ◽  
Age Discrepancy

Abstract Background and Aims Living donor kidney transplantation is the best option for patients on dialysis. There are no guidelines or generally accepted consensus about the acceptable kidney donor age and what is the acceptable donor-recipient age discrepancy. Method This is a cross sectional survey of nephrologists and transplant surgeons about acceptable age of living kidney donors. The survey was sent to participants in different countries and through AST and ERA/EDTA. Results 122 respondents from 22 countries answered 4 questions related to donor age. Most respondents (N=86, 70%) would allow an 18-years old man to donate to his older sibling. However, this percentage would fall to (N=69, 57%) if the donor was an 18-years old woman (P=0.02), reflecting the impact of childbearing period as a major criterion in considering kidney donation. On the opposite side, up to 20% of respondents will decline a very young donor regardless of the gender of the donor. The acceptance rate of a very young donor drops to only 37% if the recipient is 75-year-old (versus 70% in case of younger recipient, P = 0.004). In case of old donor( > 65 years old) old to an 18 year old recipient with expected prolonged waiting time for deceased donor, ( N= 80, 65%) will advise to find an alternative donor but will allow the donation if no alternative donor is available. Conclusion The majority of the nephrologists and transplant surgeons will allow a very young donor to donate to a sibling especially if the donor is a male. However up to 20% will decline this donation regardless of the gender of the donor. The transplant community is divided about allowing a very young donor to donate to a very old recipient. However, the majority will accept > 65 years old donor to donate to an 18 years old recipient with expected prolonged waiting time for deceased donor.

scholarly journals Human decellularized bone scaffolds from aged donors show improved osteoinductive capacity compared to young donor bone

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177416 ◽  
Author(s):  
Christopher A. Smith ◽  
Tim N. Board ◽  
Paul Rooney ◽  
Mark J. Eagle ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Young Donor ◽  
Bone Scaffolds

scholarly journals An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

2021 ◽  
Vol 9 (4) ◽  
pp. 1237-1245
Author(s):  
Yichi Xu ◽  
Heyong Yin ◽  
Jin Chu ◽  
David Eglin ◽  
Tiziano Serra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Iron Oxide ◽  
Progenitor Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Nanocomposite Hydrogel ◽  
Collagen Hydrogel ◽  
Human Tendon

An anisotropic magnetically-responsive collagen hydrogel loaded with iron oxide nanoparticles augments aligned cell row formation and tenogenic gene expression of tendon stem/progenitor cells.

Efficacy of dental pulp-derived stem cells conditioned medium loaded in collagen hydrogel in spinal cord injury in rats: Stereological evidence

2021 ◽  
Vol 116 ◽  
pp. 101978
Author(s):  
Reza Asadi-Golshan ◽  
Vahid Razban ◽  
Esmaeil Mirzaei ◽  
Abdolkarim Rahmanian ◽  
Sahar Khajeh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Conditioned Medium ◽  
Dental Pulp ◽  
Collagen Hydrogel ◽  
Cord Injury

Cartilage Regeneration with Cell-free Type 1 Collagen Matrix – Past, Present and Future (Part 1 – Clinical Aspects)

2020 ◽  
Author(s):  
Philip Peter Roessler ◽  
Turgay Efe ◽  
Dieter Christian Wirtz ◽  
Frank Alexander Schildberg
Keyword(s):  
Type I Collagen ◽  
Case Series ◽  
Cartilage Regeneration ◽  
Collagen Matrix ◽  
Treatment Method ◽  
Collagen Type I ◽  
Legal Framework ◽  
Clinical Aspects ◽  
Type I ◽  
Collagen Hydrogel

AbstractCartilage regeneration with cell-free matrices has developed from matrix-associated autologous cartilage cell transplantation (MACT) over ten years ago. Adjustments to the legal framework and higher hurdles for cell therapy have led to the procedures being established as an independent alternative to MACT. These procedures, which can be classified as matrix-induced autologous cartilage regeneration (MACR), all rely on the chemotactic stimulus of a cross-linked matrix, which mostly consists of collagens. Given the example of a commercially available type I collagen hydrogel, the state of clinical experience with MACR shall be summarized and an outlook on the development of the method shall be provided. It has been demonstrated in the clinical case series summarized here over the past few years that the use of the matrix is not only safe but also yields good clinical-functional and MR-tomographic results for both small (~ 10 mm) and large (> 10 mm) focal cartilage lesions. Depending on the size of the defect, MACR with a collagen type I matrix plays an important role as an alternative treatment method, in direct competition with both: microfracture and MACT.

scholarly journals Direct comparison of 3D and 2D cultivation reveals higher osteogenic capacity of elderly osteoblasts in 3D

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Stephan Payr ◽  
Elizabeth Rosado-Balmayor ◽  
Thomas Tiefenboeck ◽  
Tim Schuseil ◽  
Marina Unger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Collagen Type ◽  
3D Culture ◽  
Osteogenic Potential ◽  
Donor Age ◽  
Collagen Type 1 ◽  
2D And 3D ◽  
Human Primary Osteoblasts ◽  
Gene Expression Levels

Abstract Background The aim of this study was the investigation of the osteogenic potential of human osteoblasts of advanced donor age in 2D and 3D culture. Methods Osteoblasts were induced to osteogenic differentiation and cultivated, using the same polystyrene material in 2D and 3D culture for 2 weeks. Samples were taken to evaluate alkaline phosphatase (ALP) activity, mineralization and gene expression. Results Osteoprotegerin (OPG) levels were significantly increased (8.2-fold) on day 7 in 3D compared to day 0 (p < 0.0001) and 11.6-fold higher in 3D than in 2D (p < 0.0001). Both culture systems showed reduced osteocalcin (OC) levels (2D 85% and 3D 50% of basic value). Collagen type 1 (Col1) expression was elevated in 3D on day 7 (1.4-fold; p = 0.009). Osteopontin (OP) expression showed 6.5-fold higher levels on day 7 (p = 0.002) in 3D than in 2D. Mineralization was significantly higher in 3D on day 14 (p = 0.0002). Conclusion Advanced donor age human primary osteoblasts reveal significantly higher gene expression levels of OPG, Col1 and OP in 3D than in monolayer. Therefore, it seems that a relatively high potential of bone formation in a natural 3D arrangement is presumably still present in osteoblasts of elderly people. Trial registration 5217/11 on the 22nd of Dec. 2011.

scholarly journals Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model

2012 ◽  
Vol 21 (9) ◽  
pp. 1700-1708 ◽  
Author(s):  
G. W. Omlor ◽  
A. G. Nerlich ◽  
H. Lorenz ◽  
T. Bruckner ◽  
W. Richter ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Disc Degeneration ◽  
Collagen Hydrogel ◽  
Hydrogel Matrix
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