scholarly journals An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

2021 ◽  
Vol 9 (4) ◽  
pp. 1237-1245
Author(s):  
Yichi Xu ◽  
Heyong Yin ◽  
Jin Chu ◽  
David Eglin ◽  
Tiziano Serra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Iron Oxide ◽  
Progenitor Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Nanocomposite Hydrogel ◽  
Collagen Hydrogel ◽  
Human Tendon

An anisotropic magnetically-responsive collagen hydrogel loaded with iron oxide nanoparticles augments aligned cell row formation and tenogenic gene expression of tendon stem/progenitor cells.

scholarly journals Synergistic Effect of Vitamin C with Superparamagnetic Iron Oxide Nanoparticles for Inhibiting Proliferation of Gastric Cancer Cells

2021 ◽  
Vol 12 (3) ◽  
pp. 3215-3224
Keyword(s):  
Gene Expression ◽  
Iron Oxide ◽  
Vitamin C ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dependent Manner ◽  
Low Doses ◽  
Gastric Cancer Cells

The present study aimed to explore the synergistic anticancer effect of combined L-ascorbic acid (LAA) with superparamagnetic iron oxide nanoparticles (SPIONs) on adenocarcinoma gastric cell line (AGS). Fe3O4-LAA was synthesized using the reverse co-precipitation technique. XRD, FT-IR, FESEM, and TEM were employed to characterize the synthesized nanoparticles. MTT test and Real-time PCR were performed to investigate the cytotoxicity and apoptosis induced by treatments. The present study indicated that the anticancer properties of vitamin C were increased when employed as the Fe3O4-LAA nanoparticles. A dose-dependent manner on the effect of Fe3O4-LAA on investigated genes was observed; p53 gene expression changes in high and low doses of Fe3O4-LAA were 7.4 and 3.1 fold, respectively; accordingly, Bcl2 gene expression under treatment with high and low doses of Fe3O4-LAA was reduced by 71% and 25%, respectively. In conclusion, our results indicated that Fe3O4-LAA nanoparticles might be an efficient agent for cancer treatment.

scholarly journals In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

2017 ◽  
Author(s):  
Olivier Sandre ◽  
Coralie Genevois ◽  
Eneko Garaio ◽  
Laurent Adumeau ◽  
Stéphane Mornet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Non Invasive ◽  
Nanoparticles Dispersions

The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and non-invasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected sub-cutaneously with Matrigel™ to generate so called pseudo tumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 hours after heating. We showed that dextran-coated magnetic iron oxide nanoparticles dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as non-invasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.

scholarly journals Reproductive toxicity of iron oxide nanoparticles, silver nanoparticles and their mixture in male rats: Effects on testicular gene expression

2020 ◽  
Vol 7 (2) ◽  
pp. 075-081
Author(s):  
Ahmed Ibrahim Younus ◽  
Mokhtar Ibrahim Yousef ◽  
Kamel Maher Abdel-Nabi ◽  
Mohammed Ibrahim Younus ◽  
Jubran Mohammed Abdulrahman
Keyword(s):  
Gene Expression ◽  
Silver Nanoparticles ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reproductive Toxicity ◽  
Male Rats ◽  
Oxide Nanoparticles

scholarly journals Magnetic Properties of Collagen–Chitosan Hybrid Materials with Immobilized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7652
Author(s):  
Sylwia Fiejdasz ◽  
Adriana Gilarska ◽  
Tomasz Strączek ◽  
Maria Nowakowska ◽  
Czesław Kapusta
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hybrid Materials ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Collagen Hydrogel ◽  
Hydrogel Matrix ◽  
Potential Applications

The paper presents results of our studies on hybrid materials based on polymers of natural origin containing superparamagnetic iron oxide nanoparticles (SPIONs). Such nanoparticles, coated with the chitosan derivative, were immobilized in a chitosan-collagen hydrogel matrix by crosslinking with genipin. Three types of biopolymer matrices of different collagen-to-chitosan ratios were studied. A thorough magnetic characterization was performed, including magnetic susceptibility, magnetization, and hysteresis loop measurements in a temperature range of 4 K to 300 K and a magnetic field induction up to 8 Tesla. The effect of SPION immobilization and material composition on the magnetic properties of the hybrids was investigated. The results showed that hybrid materials with covalently bounded SPIONs preserved the superparamagnetic character of SPIONs and exhibited promising magnetic properties, which are important for their potential applications.

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