scholarly journals Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia

2014 ◽  
Vol 40 (7) ◽  
pp. 3111-3119 ◽  
Author(s):  
Derrick D. Rowe ◽  
Lisa A. Collier ◽  
Hilary A. Seifert ◽  
Cortney B. Chapman ◽  
Christopher C. Leonardo ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Focal Ischemia ◽  
Rat Models ◽  
Leukemia Inhibitor Factor

Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils

2004 ◽  
Vol 78 (2) ◽  
pp. 215-223 ◽  
Author(s):  
Satoru Ishibashi ◽  
Masanori Sakaguchi ◽  
Toshihiko Kuroiwa ◽  
Mami Yamasaki ◽  
Yonehiro Kanemura ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Functional Recovery ◽  
Focal Ischemia ◽  
Mongolian Gerbils ◽  
Neurosphere Culture ◽  
Neural Stem Progenitor Cells

scholarly journals Effects of Tissue Type Plasminogen Activator in Embolic versus Mechanical Models of Focal Cerebral Ischemia in Rats

1999 ◽  
Vol 19 (12) ◽  
pp. 1316-1321 ◽  
Author(s):  
Wei Meng ◽  
Xiaoying Wang ◽  
Minoru Asahi ◽  
Tsuneo Kano ◽  
Kazuko Asahi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cerebral Perfusion ◽  
Focal Cerebral Ischemia ◽  
Focal Ischemia ◽  
Tissue Type ◽  
Negative Effects ◽  
Tissue Type Plasminogen Activator ◽  
Rat Models ◽  
Type Plasminogen Activator ◽  
Transient Focal Ischemia

Tissue type plasminogen activator (tPA) can be effective therapy for embolic stroke by restoring cerebral perfusion. However, a recent experimental study showed that tPA increased infarct size in a mouse model of transient focal ischemia, suggesting a possible adverse effect of tPA on ischemic tissue per se. In this report, the effects of tPA in two rat models of cerebral ischemia were compared. In experiment 1, rats were subjected to focal ischemia via injection of autologous clots into the middle cerebral artery territory. Two hours after clot injection, rats were treated with 10 mg/kg tPA or normal saline. Perfusion-sensitive computed tomography scanning showed that tPA restored cerebral perfusion in this thromboembolic model. Treatment with tPA significantly reduced ischemic lesion volumes measured at 24 hours by >60%. In experiment 2, three groups of rats were subjected to focal ischemia via a mechanical approach in which a silicon-coated filament was used intraluminally to occlude the origin of the middle cerebral artery. In two groups, the filament was withdrawn after 2 hours to allow for reperfusion, and then rats were randomly treated with 10 mg/kg tPA or normal saline. In the third group, rats were not treated and the filament was not withdrawn so that permanent focal ischemia was present. In this experiment, tPA did not significantly alter lesion volumes after 2 hours of transient focal ischemia. In contrast, permanent ischemia significantly increased lesion volumes by 55% compared with transient ischemia. These results indicate that in these rat models of focal cerebral ischemia, tPA did not have detectable negative effects. Other potentially negative effects of tPA may be dependent on choice of animal species and model systems.

scholarly journals Effects of skilled and unskilled training on functional recovery and brain plasticity after focal ischemia in adult rats

2012 ◽  
Vol 1486 ◽  
pp. 53-61 ◽  
Author(s):  
A.S. Pagnussat ◽  
F. Simao ◽  
J.R. Anastacio ◽  
R.G. Mestriner ◽  
S.M. Michaelsen ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Brain Plasticity ◽  
Focal Ischemia ◽  
Adult Rats

Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender

2004 ◽  
Vol 187 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Xiaoling Li ◽  
Kathleen K. Blizzard ◽  
Zhiyuan Zeng ◽  
A.Courtney DeVries ◽  
Patricia D. Hurn ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Focal Ischemia ◽  
Behavioral Testing

scholarly journals Delayed Administration of Human Umbilical Tissue-Derived Cells Improved Neurological Functional Recovery in a Rodent Model of Focal Ischemia

Stroke ◽  
2011 ◽  
Vol 42 (5) ◽  
pp. 1437-1444 ◽  
Author(s):  
Li Zhang ◽  
Yi Li ◽  
Chunling Zhang ◽  
Michael Chopp ◽  
Anna Gosiewska ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Focal Ischemia ◽  
Rodent Model

scholarly journals The Effects of Repeated Rehabilitation “Tune-Ups” on Functional Recovery After Focal Ischemia in Rats

2009 ◽  
Vol 23 (9) ◽  
pp. 886-894 ◽  
Author(s):  
Jared Clarke ◽  
Hana Mala ◽  
Victoria Windle ◽  
Garry Chernenko ◽  
Dale Corbett
Keyword(s):  
Functional Recovery ◽  
Focal Ischemia
Sign in / Sign up

Export Citation Format

Share Document