DNA interstrand cross-link repair: understanding role of Fanconi anemia pathway and therapeutic implications

2013 ◽  
Vol 91 (5) ◽  
pp. 381-393 ◽  
Author(s):  
Pallavi Shukla ◽  
Avani Solanki ◽  
Kanjaksha Ghosh ◽  
Babu Rao Vundinti
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway ◽  
Therapeutic Implications

scholarly journals The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

Science ◽  
2009 ◽  
Vol 326 (5960) ◽  
pp. 1698-1701 ◽  
Author(s):  
P. Knipscheer ◽  
M. Raschle ◽  
A. Smogorzewska ◽  
M. Enoiu ◽  
T. V. Ho ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer

2015 ◽  
Vol 86 (2) ◽  
pp. 150-154
Author(s):  
Agnieszka Synowiec ◽  
Jolanta Szenajch ◽  
Gabriel Wcisło ◽  
Cezary Szczylik
Keyword(s):  
Ovarian Cancer ◽  
Fanconi Anemia ◽  
Fanconi Anemia Pathway

scholarly journals Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway

2007 ◽  
Vol 27 (8) ◽  
pp. 3098-3108 ◽  
Author(s):  
XiaoZhe Wang ◽  
Richard D. Kennedy ◽  
Kallol Ray ◽  
Patricia Stuckert ◽  
Tom Ellenberger ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Mutant Form ◽  
Cross Link ◽  
Core Complex ◽  
Core Enzyme ◽  
Cross Links ◽  
Phase Progression ◽  
Nuclear Foci ◽  
Fancd2 Monoubiquitination

ABSTRACT The eleven Fanconi anemia (FA) proteins cooperate in a novel pathway required for the repair of DNA cross-links. Eight of the FA proteins (A, B, C, E, F, G, L, and M) form a core enzyme complex, required for the monoubiquitination of FANCD2 and the assembly of FANCD2 nuclear foci. Here, we show that, in response to DNA damage, Chk1 directly phosphorylates the FANCE subunit of the FA core complex on two conserved sites (threonine 346 and serine 374). Phosphorylated FANCE assembles in nuclear foci and colocalizes with FANCD2. A nonphosphorylated mutant form of FANCE (FANCE-T346A/S374A), when expressed in a FANCE-deficient cell line, allows FANCD2 monoubiquitination, FANCD2 foci assembly, and normal S-phase progression. However, the mutant FANCE protein fails to complement the mitomycin C hypersensitivity of the transfected cells. Taken together, these results elucidate a novel role of Chk1 in the regulation of the FA/BRCA pathway and in DNA cross-link repair. Chk1-mediated phosphorylation of FANCE is required for a function independent of FANCD2 monoubiquitination.

scholarly journals Tip60 Is Required for DNA Interstrand Cross-link Repair in the Fanconi Anemia Pathway

2008 ◽  
Vol 283 (15) ◽  
pp. 9844-9851 ◽  
Author(s):  
James Hejna ◽  
Megan Holtorf ◽  
Jennie Hines ◽  
Lauren Mathewson ◽  
Aaron Hemphill ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The Fanconi anemia pathway and DNA interstrand cross-link repair

2011 ◽  
Vol 2 (9) ◽  
pp. 704-711 ◽  
Author(s):  
Xiaoyu Su ◽  
Jun Huang
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The role of FAN1 nuclease in the Fanconi anemia pathway

Cell Cycle ◽  
2010 ◽  
Vol 9 (21) ◽  
pp. 4266-4265 ◽  
Author(s):  
Maria Castella ◽  
Toshiyasu Taniguchi
Keyword(s):  
Fanconi Anemia ◽  
Fanconi Anemia Pathway

scholarly journals Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

2011 ◽  
Vol 18 (4) ◽  
pp. 500-503 ◽  
Author(s):  
Koji Nakanishi ◽  
Francesca Cavallo ◽  
Loïc Perrouault ◽  
Carine Giovannangeli ◽  
Mary Ellen Moynahan ◽  
...  
Keyword(s):  
Dna Replication ◽  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

The Fanconi Anemia Pathway and Interstrand Cross-Link Repair

2016 ◽  
pp. 175-210 ◽  
Author(s):  
Masamichi Ishiai ◽  
Junya Tomida ◽  
Akiko Itaya ◽  
James Hejna ◽  
Minoru Takata
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway
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