scholarly journals Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

2011 ◽  
Vol 18 (4) ◽  
pp. 500-503 ◽  
Author(s):  
Koji Nakanishi ◽  
Francesca Cavallo ◽  
Loïc Perrouault ◽  
Carine Giovannangeli ◽  
Mary Ellen Moynahan ◽  
...  
Keyword(s):  
Dna Replication ◽  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

Science ◽  
2009 ◽  
Vol 326 (5960) ◽  
pp. 1698-1701 ◽  
Author(s):  
P. Knipscheer ◽  
M. Raschle ◽  
A. Smogorzewska ◽  
M. Enoiu ◽  
T. V. Ho ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA

2021 ◽  
Vol 9 ◽  
Author(s):  
Qiuzhen Li ◽  
Kata Dudás ◽  
Gabriella Tick ◽  
Lajos Haracska
Keyword(s):  
Dna Replication ◽  
Fanconi Anemia ◽  
Replication Fork ◽  
Defense Mechanism ◽  
Genome Instability ◽  
Dna Lesions ◽  
Fanconi Anemia Pathway ◽  
Interstrand Crosslinks ◽  
Dna Lesion ◽  
Interstrand Crosslink

DNA interstrand crosslinks (ICLs) are covalently bound DNA lesions, which are commonly induced by chemotherapeutic drugs, such as cisplatin and mitomycin C or endogenous byproducts of metabolic processes. This type of DNA lesion can block ongoing RNA transcription and DNA replication and thus cause genome instability and cancer. Several cellular defense mechanism, such as the Fanconi anemia pathway have developed to ensure accurate repair and DNA replication when ICLs are present. Various structure-specific nucleases and translesion synthesis (TLS) polymerases have come into focus in relation to ICL bypass. Current models propose that a structure-specific nuclease incision is needed to unhook the ICL from the replication fork, followed by the activity of a low-fidelity TLS polymerase enabling replication through the unhooked ICL adduct. This review focuses on how, in parallel with the Fanconi anemia pathway, PCNA interactions and ICL-induced PCNA ubiquitylation regulate the recruitment, substrate specificity, activity, and coordinated action of certain nucleases and TLS polymerases in the execution of stalled replication fork rescue via ICL bypass.

scholarly journals Tip60 Is Required for DNA Interstrand Cross-link Repair in the Fanconi Anemia Pathway

2008 ◽  
Vol 283 (15) ◽  
pp. 9844-9851 ◽  
Author(s):  
James Hejna ◽  
Megan Holtorf ◽  
Jennie Hines ◽  
Lauren Mathewson ◽  
Aaron Hemphill ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The Fanconi anemia pathway and DNA interstrand cross-link repair

2011 ◽  
Vol 2 (9) ◽  
pp. 704-711 ◽  
Author(s):  
Xiaoyu Su ◽  
Jun Huang
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

The Fanconi Anemia Pathway and Interstrand Cross-Link Repair

2016 ◽  
pp. 175-210 ◽  
Author(s):  
Masamichi Ishiai ◽  
Junya Tomida ◽  
Akiko Itaya ◽  
James Hejna ◽  
Minoru Takata
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

scholarly journals The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

2005 ◽  
Vol 14 (5) ◽  
pp. 693-701 ◽  
Author(s):  
Niall G. Howlett ◽  
Toshiyasu Taniguchi ◽  
Sandra G. Durkin ◽  
Alan D. D'Andrea ◽  
Thomas W. Glover
Keyword(s):  
Dna Replication ◽  
Stress Response ◽  
Fanconi Anemia ◽  
Fragile Site ◽  
Replication Stress ◽  
Common Fragile Site ◽  
Fanconi Anemia Pathway ◽  
Dna Replication Stress

scholarly journals Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

2011 ◽  
Vol 108 (16) ◽  
pp. 6492-6496 ◽  
Author(s):  
K. N. Yamamoto ◽  
S. Kobayashi ◽  
M. Tsuda ◽  
H. Kurumizaka ◽  
M. Takata ◽  
...  
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway

DNA interstrand cross-link repair: understanding role of Fanconi anemia pathway and therapeutic implications

2013 ◽  
Vol 91 (5) ◽  
pp. 381-393 ◽  
Author(s):  
Pallavi Shukla ◽  
Avani Solanki ◽  
Kanjaksha Ghosh ◽  
Babu Rao Vundinti
Keyword(s):  
Fanconi Anemia ◽  
Cross Link ◽  
Fanconi Anemia Pathway ◽  
Therapeutic Implications
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