Aberrant salience in first‐episode psychosis: Longitudinal stability and treatment‐response

2021 ◽  
Author(s):  
Ilaria Scazza ◽  
Lorenzo Pelizza ◽  
Silvia Azzali ◽  
Sara Garlassi ◽  
Federica Paterlini ◽  
...  
Keyword(s):  
Treatment Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Longitudinal Stability ◽  
Episode Psychosis ◽  
Aberrant Salience

scholarly journals Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response

2018 ◽  
Vol 13 (2) ◽  
pp. 541-553 ◽  
Author(s):  
Keith M. Shafritz ◽  
Toshikazu Ikuta ◽  
Allison Greene ◽  
Delbert G. Robinson ◽  
Juan Gallego ◽  
...  
Keyword(s):  
Treatment Response ◽  
Frontal Lobe ◽  
First Episode Psychosis ◽  
Response Conflict ◽  
First Episode ◽  
Conflict Task ◽  
Episode Psychosis ◽  
Frontal Lobe Functioning

Pituitary volume and early treatment response in drug-naïve first-episode psychosis patients

2009 ◽  
Vol 113 (1) ◽  
pp. 65-71 ◽  
Author(s):  
B. Garner ◽  
G.E. Berger ◽  
J.P. Nicolo ◽  
A. Mackinnon ◽  
S.J. Wood ◽  
...  
Keyword(s):  
Treatment Response ◽  
Early Treatment ◽  
First Episode Psychosis ◽  
First Episode ◽  
Early Treatment Response ◽  
Episode Psychosis ◽  
Drug Naïve

BRAIN ACTIVATION DURING THE N-BACK TASK AS A PREDICTOR OF FUTURE TREATMENT RESPONSE IN FIRST EPISODE PSYCHOSIS PATIENTS

2010 ◽  
Vol 117 (2-3) ◽  
pp. 472-473
Author(s):  
Heather Taylor ◽  
Tiago Reis Marques ◽  
Andy Simmons ◽  
A.A.T. Simone Reinders ◽  
Rowena Handley ◽  
...  
Keyword(s):  
Treatment Response ◽  
Brain Activation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Future Treatment ◽  
Episode Psychosis ◽  
Back Task

Predictors of treatment response to psychological interventions in people at clinical high risk of first-episode psychosis

2017 ◽  
Vol 13 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Helen Wessels ◽  
Michael Wagner ◽  
Kathrin Kuhr ◽  
Julia Berning ◽  
Verena Pützfeld ◽  
...  
Keyword(s):  
High Risk ◽  
Treatment Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Psychological Interventions ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals Association of a Schizophrenia Risk Variant at theDRD2Locus With Antipsychotic Treatment Response in First-Episode Psychosis

2015 ◽  
Vol 41 (6) ◽  
pp. 1248-1255 ◽  
Author(s):  
Jian-Ping Zhang ◽  
Delbert G. Robinson ◽  
Juan A. Gallego ◽  
Majnu John ◽  
Jin Yu ◽  
...  
Keyword(s):  
Treatment Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Risk Variant ◽  
Episode Psychosis

scholarly journals Anterior Hippocampal–Cortical Functional Connectivity Distinguishes Antipsychotic Naïve First-Episode Psychosis Patients From Controls and May Predict Response to Second-Generation Antipsychotic Treatment

2019 ◽  
Vol 46 (3) ◽  
pp. 680-689 ◽  
Author(s):  
Esther M Blessing ◽  
Vishnu P Murty ◽  
Botao Zeng ◽  
Jijun Wang ◽  
Lila Davachi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Random Forest ◽  
Treatment Response ◽  
Second Generation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Episode Psychosis ◽  
Second Generation Antipsychotic ◽  
Cortical Regions

Abstract Background Converging evidence implicates the anterior hippocampus in the proximal pathophysiology of schizophrenia. Although resting state functional connectivity (FC) holds promise for characterizing anterior hippocampal circuit abnormalities and their relationship to treatment response, this technique has not yet been used in first-episode psychosis (FEP) patients in a manner that distinguishes the anterior from posterior hippocampus. Methods We used masked-hippocampal-group-independent component analysis with dual regression to contrast subregional hippocampal–whole brain FC between healthy controls (HCs) and antipsychotic naïve FEP patients (N = 61, 36 female). In a subsample of FEP patients (N = 27, 15 female), we repeated this analysis following 8 weeks of second-generation antipsychotic treatment and explored whether baseline FC predicted treatment response using random forest. Results Relative to HC, untreated FEP subjects displayed reproducibly lower FC between the left anteromedial hippocampus and cortical regions including the anterior cingulate and insular cortex (P < .05, corrected). Anteromedial hippocampal FC increased in FEP patients following treatment (P < .005), and no longer differed from HC. Random forest analysis showed baseline anteromedial hippocampal FC with four brain regions, namely the insular–opercular cortex, superior frontal gyrus, precentral gyrus, and postcentral gyrus predicted treatment response (area under the curve = 0.95). Conclusions Antipsychotic naïve FEP is associated with lower FC between the anterior hippocampus and cortical regions previously implicated in schizophrenia. Preliminary analysis suggests that random forest models based on hippocampal FC may predict treatment response in FEP patients, and hence could be a useful biomarker for treatment development.

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