Predictors of treatment response to psychological interventions in people at clinical high risk of first-episode psychosis

2017 ◽  
Vol 13 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Helen Wessels ◽  
Michael Wagner ◽  
Kathrin Kuhr ◽  
Julia Berning ◽  
Verena Pützfeld ◽  
...  
Keyword(s):  
High Risk ◽  
Treatment Response ◽  
First Episode Psychosis ◽  
First Episode ◽  
Psychological Interventions ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis

2021 ◽  
Author(s):  
Meike Heurich ◽  
Melanie Föcking ◽  
David Mongan ◽  
Gerard Cagney ◽  
David R. Cotter
Keyword(s):  
High Risk ◽  
Psychotic Disorder ◽  
Psychotic Disorders ◽  
Clinical Symptoms ◽  
First Episode Psychosis ◽  
Specific Protein ◽  
First Episode ◽  
Clinical High Risk ◽  
Blood Proteins ◽  
Episode Psychosis

AbstractEarly identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma proteins as diagnostic or prognostic biomarkers and pathophysiological mediators. In this review, we integrate evidence of alterations in proteins belonging to the complement and coagulation protein systems, including the coagulation, anticoagulation, and fibrinolytic pathways and their dysregulation in psychosis, into a consolidated mechanism that could be integral to the progression and manifestation of psychosis. We consolidate the findings of altered blood proteins relevant for progression to psychotic disorders, using data from longitudinal studies of the general population in addition to clinical high-risk (CHR) individuals transitioning to psychotic disorder. These are compared to markers identified from first-episode psychosis and schizophrenia as well as other psychosis spectrum disorders. We propose the novel hypothesis that altered complement and coagulation plasma levels enhance their pathways’ activating capacities, while low levels observed in key regulatory components contribute to excessive activation observed in patients. This hypothesis will require future testing through a range of experimental paradigms, and if upheld, complement and coagulation pathways or specific proteins could be useful diagnostic or prognostic tools and targets for early intervention and preventive strategies.

Reduced P3a amplitudes in antipsychotic naïve first-episode psychosis patients and individuals at clinical high-risk for psychosis

2013 ◽  
Vol 47 (6) ◽  
pp. 755-761 ◽  
Author(s):  
Alejandra Mondragón-Maya ◽  
Rodolfo Solís-Vivanco ◽  
Pablo León-Ortiz ◽  
Yaneth Rodríguez-Agudelo ◽  
Guillermina Yáñez-Téllez ◽  
...  
Keyword(s):  
High Risk ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals O8.4. CORTICAL DOPAMINE RELEASE IN RESPONSE TO A COGNITIVE CHALLENGE: PRELIMINARY RESULTS IN FIRST EPISODE PSYCHOSIS AND CLINICAL HIGH RISK

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S184-S184
Author(s):  
Abanti Tagore ◽  
Naren Rao ◽  
Christin Schifani ◽  
Huai-Hsuan Tseng ◽  
Pablo Rusjan ◽  
...  
Keyword(s):  
High Risk ◽  
Dopamine Release ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Preliminary Results ◽  
Episode Psychosis ◽  
Cognitive Challenge

scholarly journals 117.3 Imaging Microglial Activation in Clinical High Risk for Psychosis and Untreated First-Episode Psychosis: A PET StudyW [18F]FEPPA

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S64-S64 ◽  
Author(s):  
Romina Mizrahi ◽  
Sina Hafizi ◽  
Cory Gerritsen ◽  
Michael Kiang ◽  
Michael Bargby ◽  
...  
Keyword(s):  
High Risk ◽  
Microglial Activation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

Poster #T180 THE COURSE OF COGNITIVE FUNCTIONING IN CLINICAL HIGH RISK AND FIRST-EPISODE PSYCHOSIS INDIVIDUALS

2014 ◽  
Vol 153 ◽  
pp. S352-S353
Author(s):  
Martina Papmeyer ◽  
Erich Studerus ◽  
Marlon Pflüger ◽  
Sarah Ittig ◽  
Avinash Ramyead ◽  
...  
Keyword(s):  
High Risk ◽  
Cognitive Functioning ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis

scholarly journals O9.1. PROSPECTIVE MEMORY AND THE RELATIONSHIP TO SOCIAL FUNCTION AND NEGATIVE SYMPTOMS IN CLINICAL HIGH RISK, FIRST EPISODE PSYCHOSIS, AND SCHIZOPHRENIA

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S186-S187
Author(s):  
Anne Marie Teti ◽  
Patricia C Graham ◽  
Mallory Fergione ◽  
Lawrence C Haber ◽  
Joanna M Fiszdon ◽  
...  
Keyword(s):  
High Risk ◽  
Prospective Memory ◽  
Negative Symptoms ◽  
Social Function ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis ◽  
The Relationship

scholarly journals Is the Clinical High-Risk State a Valid Concept? Retrospective Examination in a First-Episode Psychosis Sample

2017 ◽  
Vol 68 (10) ◽  
pp. 1046-1052 ◽  
Author(s):  
Jai L. Shah ◽  
Anne Crawford ◽  
Sally S. Mustafa ◽  
Srividya N. Iyer ◽  
Ridha Joober ◽  
...  
Keyword(s):  
High Risk ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis ◽  
Retrospective Examination

scholarly journals Episodic memory functions in first episode psychosis and clinical high risk individuals

2017 ◽  
Vol 188 ◽  
pp. 151-157 ◽  
Author(s):  
Sarah E. Greenland-White ◽  
J. Daniel Ragland ◽  
Tara A. Niendam ◽  
Emilio Ferrer ◽  
Cameron S. Carter
Keyword(s):  
High Risk ◽  
Episodic Memory ◽  
First Episode Psychosis ◽  
First Episode ◽  
Clinical High Risk ◽  
Memory Functions ◽  
Episode Psychosis

scholarly journals Hippocampal glutamate metabolites and glial activation in clinical high risk and first episode psychosis

2018 ◽  
Vol 43 (11) ◽  
pp. 2249-2255 ◽  
Author(s):  
Shima Shakory ◽  
Jeremy J. Watts ◽  
Sina Hafizi ◽  
Tania Da Silva ◽  
Saad Khan ◽  
...  
Keyword(s):  
High Risk ◽  
First Episode Psychosis ◽  
Glial Activation ◽  
First Episode ◽  
Clinical High Risk ◽  
Episode Psychosis
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