scholarly journals Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules

2018 ◽  
Vol 48 (6) ◽  
pp. e12934 ◽  
Author(s):  
Luca Giovanella ◽  
Mauro Imperiali ◽  
Arnoldo Piccardo ◽  
Monica Taborelli ◽  
Frederik Anton Verburg ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Prospective Evaluation ◽  
Medullary Thyroid

scholarly journals Pathogenesis, diagnosis and management of thyroid nodules in children

2006 ◽  
Vol 13 (2) ◽  
pp. 427-453 ◽  
Author(s):  
M Niedziela
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Preoperative Diagnosis ◽  
Thyroid Nodules ◽  
Follicular Adenoma ◽  
Critical Factor ◽  
Anaplastic Thyroid Carcinoma ◽  
Duct Cyst ◽  
Medullary Thyroid ◽  
Molecular Studies

According to the literature thyroid nodules are quite rare in the first two decades of life. However, there are some exceptions, relating to areas with an iodine deficiency or affected by radioactive fallout, where the risk of nodules and carcinomas is increased. Therefore, it is a great challenge for the physician to distinguish between benign and malignant lesions preoperatively, and not only in these areas of greater risk. A careful work-up, comprising the patient’s history, clinical examination, laboratory tests, thyroid ultrasound, scintigraphy, fine-needle aspiration biopsy (FNAB) and molecular studies, is mandatory to improve the preoperative diagnosis. The differential diagnosis should also include benign thyroid conditions such as: (i) congenital hypothyroidism due to dyshormonogenesis or ectopy, (ii) thyroid hemiagenesis, (iii) thyroglossal duct cyst, (iv) simple goiter, (v) cystic lesion, (vi) nodular hyperplasia, (vii) follicular adenoma, (viii) Graves’ disease and (ix) Hashimoto thyroiditis, all of which can predispose to the development of thyroid nodules. The majority of thyroid carcinomas derive from the follicular cell (papillary, follicular, insular and undifferentiated (or anaplastic) thyroid carcinoma), whereas medullary thyroid carcinoma derives from calcitonin-producing cells. Inherited forms of thyroid cancer may occur, especially in relation to medullary thyroid carcinoma. FNAB is a critical factor in establishing the preoperative diagnosis. However, we should keep in mind the fact that a conventional cytological evaluation can miss the neoplastic nature of a lesion and the employment of immunocytochemical and molecular studies of aspirates from FNAB can give us a more precise diagnosis of neoplasia in thyroid nodules once they are detected.

Prospective evaluation of 68Ga-DOTA-NOC PET-CT in patients with recurrent medullary thyroid carcinoma

2012 ◽  
Vol 33 (7) ◽  
pp. 766-774 ◽  
Author(s):  
Niraj Naswa ◽  
Punit Sharma ◽  
Sudhir Suman KC ◽  
Sneh Lata ◽  
Rakesh Kumar ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Prospective Evaluation ◽  
Medullary Thyroid ◽  
Pet Ct

Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules

2013 ◽  
Vol 51 (7) ◽  
Author(s):  
Luca Giovanella ◽  
Frederik A. Verburg ◽  
Mauro Imperiali ◽  
Stefano Valabrega ◽  
Pierpaolo Trimboli ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Serum Calcitonin ◽  
Medullary Thyroid
Sign in / Sign up

Export Citation Format

Share Document