scholarly journals Predictive Value of Serum Calcitonin Levels for Preoperative Diagnosis of Medullary Thyroid Carcinoma in a Cohort of 5817 Consecutive Patients with Thyroid Nodules

2006 ◽  
Vol 92 (2) ◽  
pp. 450-455 ◽  
Author(s):  
Giuseppe Costante ◽  
Domenico Meringolo ◽  
Cosimo Durante ◽  
Davide Bianchi ◽  
Maria Nocera ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Predictive Value ◽  
Preoperative Diagnosis ◽  
Thyroid Nodules ◽  
Serum Calcitonin ◽  
Medullary Thyroid

scholarly journals Pathogenesis, diagnosis and management of thyroid nodules in children

2006 ◽  
Vol 13 (2) ◽  
pp. 427-453 ◽  
Author(s):  
M Niedziela
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Preoperative Diagnosis ◽  
Thyroid Nodules ◽  
Follicular Adenoma ◽  
Critical Factor ◽  
Anaplastic Thyroid Carcinoma ◽  
Duct Cyst ◽  
Medullary Thyroid ◽  
Molecular Studies

According to the literature thyroid nodules are quite rare in the first two decades of life. However, there are some exceptions, relating to areas with an iodine deficiency or affected by radioactive fallout, where the risk of nodules and carcinomas is increased. Therefore, it is a great challenge for the physician to distinguish between benign and malignant lesions preoperatively, and not only in these areas of greater risk. A careful work-up, comprising the patient’s history, clinical examination, laboratory tests, thyroid ultrasound, scintigraphy, fine-needle aspiration biopsy (FNAB) and molecular studies, is mandatory to improve the preoperative diagnosis. The differential diagnosis should also include benign thyroid conditions such as: (i) congenital hypothyroidism due to dyshormonogenesis or ectopy, (ii) thyroid hemiagenesis, (iii) thyroglossal duct cyst, (iv) simple goiter, (v) cystic lesion, (vi) nodular hyperplasia, (vii) follicular adenoma, (viii) Graves’ disease and (ix) Hashimoto thyroiditis, all of which can predispose to the development of thyroid nodules. The majority of thyroid carcinomas derive from the follicular cell (papillary, follicular, insular and undifferentiated (or anaplastic) thyroid carcinoma), whereas medullary thyroid carcinoma derives from calcitonin-producing cells. Inherited forms of thyroid cancer may occur, especially in relation to medullary thyroid carcinoma. FNAB is a critical factor in establishing the preoperative diagnosis. However, we should keep in mind the fact that a conventional cytological evaluation can miss the neoplastic nature of a lesion and the employment of immunocytochemical and molecular studies of aspirates from FNAB can give us a more precise diagnosis of neoplasia in thyroid nodules once they are detected.

Predictive value of calcium test for preoperative diagnosis of medullary thyroid carcinoma in patients with moderately elevated basal calcitonin

2021 ◽  
Author(s):  
Katarina M. Tausanovic ◽  
Vladan R. Zivaljevic ◽  
Goran V. Zorić ◽  
Milan D. Jovanovic ◽  
Boban G. Stepanovic ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Predictive Value ◽  
Preoperative Diagnosis ◽  
Medullary Thyroid

Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules

2013 ◽  
Vol 51 (7) ◽  
Author(s):  
Luca Giovanella ◽  
Frederik A. Verburg ◽  
Mauro Imperiali ◽  
Stefano Valabrega ◽  
Pierpaolo Trimboli ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Serum Calcitonin ◽  
Medullary Thyroid

scholarly journals Incidental detection of familial medullary thyroid carcinoma by calcitonin screening for nodular thyroid disease

1999 ◽  
pp. 286-289 ◽  
Author(s):  
B Mayr ◽  
G Brabant ◽  
A von zur Muhlen
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Calcitonin Screening

Serum calcitonin screening has recently been found to be a useful supplement to fine-needle aspiration biopsy, ultrasound and radionuclide imaging in the evaluation of thyroid nodules. We describe a case where introduction of routine calcitonin screening in nodular thyroid disease led to the detection of a family with medullary thyroid carcinoma. The benefits and problems of basal and stimulated serum calcitonin testing and ret-proto-oncogene mutation studies are exemplified and we discuss the appropriate use and interpretation of these tests. We conclude that routine basal serum calcitonin measurement in nodular thyroid disease and thoughtful use of ret-mutation analysis is cost-effective in detecting medullary thyroid carcinoma and multiple endocrine neoplasia type II.

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