scholarly journals Lichenoid eruptions with interface dermatitis and necrotic subepidermal blister associated with COVID ‐19

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Zohreh Tehranchinia ◽  
Zahra Asadi‐Kani ◽  
Hoda Rahimi
Keyword(s):  
Subepidermal Blister

A Case of Subepidermal Blister Disease Associated with Autoantibody against 450 kD Protein

1992 ◽  
Vol 19 (10) ◽  
pp. 610-613 ◽  
Author(s):  
Sakuhei Fujiwara ◽  
Hiroshi Shinkai ◽  
Susumu Takayasu ◽  
Katsushi Owaribe ◽  
Shoichiro Tsukita ◽  
...  
Keyword(s):  
Subepidermal Blister

Case with Brunsting-Perry-like localized subepidermal blister formations and immunoglobulin G antibodies against unidentified basement membrane zone antigen

2015 ◽  
Vol 43 (4) ◽  
pp. 426-428 ◽  
Author(s):  
Mami Sato-Shibuya ◽  
Teruki Dainichi ◽  
Gyohei Egawa ◽  
Tetsuya Honda ◽  
Atsushi Otsuka ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Immunoglobulin G ◽  
Basement Membrane Zone ◽  
Subepidermal Blister

scholarly journals Penfigoide Bolhoso Tratado com Sucesso com Rituximab

2017 ◽  
Vol 30 (3) ◽  
pp. 243 ◽  
Author(s):  
Nuno Silva ◽  
Andreia Costa ◽  
Fernando Salvador ◽  
Elisa Serradeiro
Keyword(s):  
Autoimmune Disease ◽  
Bullous Pemphigoid ◽  
Biological Agents ◽  
First Line ◽  
Blister Formation ◽  
Subepidermal Blister

Bullous pemphigoid is an autoimmune disease characterized by subepidermal blister formation. Can be self-limiting but when necessary treatment includes the use of corticosteroids, immunosuppressants, and biological agents. We present the case of a 37 year old patient with a severe and refractory presentation of bullous pemphigoid. After about a month of treatment with various first line drugs and with no response, we chose to start rituximab and clear improvement of the lesions was observed. The authors aim to highlight the usefulness and effectiveness of this drug in this disease.

scholarly journals Bullous Pemphigoid- A Rare Case report

2021 ◽  
pp. 151-155
Author(s):  
Mayur B. Wanjari ◽  
Deeplata Mendhe ◽  
Pratibha Wankhede ◽  
Sagar Alwadkar ◽  
Hina Rodge
Keyword(s):  
Bullous Pemphigoid ◽  
Rare Case ◽  
The Elderly ◽  
Final Diagnosis ◽  
The Body ◽  
Clear Fluid ◽  
Case Presentation ◽  
Mucous Membranes ◽  
Rare Case Report ◽  
Subepidermal Blister

Introduction: The most severe autoimmune subepidermal blistering condition of the skin and mucous membranes is bullous pemphigoid (BP). In Europe, it is estimated to affect 1 in every 4,000 people. Currently incidence range between 2-22/1,000,000 worldwide. It primarily affects the elderly and is diagnosed using clinical, histologic, and immunologic criteria. Clinically, it appears as diffuse eczematous, pruritic, urticaria-like lesions with the later emergence of tense bullae or blistering lesions filled with clear fluid. Case Presentation: Here, we report a case of a 50- years old female patient with a complaint of itchy lesions with wounds all over the body present with an 8-month of history. A subepidermal blister with eosinophils and neutrophils infiltration was discovered on histopathological evaluation. Salt-split indirect immunofluorescence revealed linear deposition of IgG at the dermo-epidermal junction. On further investigation, using diagnostic and Interventional aids a final diagnosis of Bullous pemphigoid.

Idiopathic linear IgA bullous dermatosis treated with prednisone

2021 ◽  
Vol 14 (5) ◽  
pp. e242237
Author(s):  
Christopher Cantoria Garces ◽  
M Fahad Salam ◽  
Brian Nohomovich ◽  
Merryl Treasa Varghese
Keyword(s):  
Case Reports ◽  
Acute Onset ◽  
Direct Immunofluorescence ◽  
Dermoepidermal Junction ◽  
Mucosal Surfaces ◽  
Bullous Dermatosis ◽  
History Of ◽  
Linear Iga Bullous Dermatosis ◽  
Linear Band ◽  
Subepidermal Blister

We present a case of a 43-year-old man with a medical history of paroxysmal atrial fibrillation that presented with acute onset generalised vesiculobullous rash of 1-week duration. The rash was initially noticed on his groin and then spread to his hands, feet and mucosal surfaces. Laboratory tests were unremarkable, including an extensive infection aetiology work-up. Punch biopsies were obtained of a fresh lesion and were stained with H&E and sent for direct immunofluorescence. Light microscopy and immunofluorescence study demonstrated a subepidermal blister with predominant neutrophilic infiltrates and a linear band of IgA at the dermoepidermal junction, respectively. The patient was diagnosed with linear IgA bullous dermatosis and was subsequently treated with 0.5 mg/kg of prednisone daily following previous case reports. At 1-week follow-up as an outpatient, the bullae became crusted, and the rash was nearly completely regressed.

Distinguishing Epidermolysis Bullosa Acquisita From Bullous Pemphigoid Without Direct Immunofluorescence

2017 ◽  
Vol 22 (1) ◽  
pp. 22-24 ◽  
Author(s):  
Kerry M. Gardner ◽  
Richard I. Crawford
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Epidermolysis Bullosa ◽  
Periodic Acid ◽  
Epidermolysis Bullosa Acquisita ◽  
Direct Immunofluorescence ◽  
Periodic Acid Schiff ◽  
Eosinophilic Infiltrate ◽  
Neutrophilic Infiltrate ◽  
Subepidermal Blister

Background: It has been postulated that periodic acid–Schiff staining of basement membrane can predict direct immunofluorescence patterns seen in epidermolysis bullosa acquisita and bullous pemphigoid. It has also been suggested that the type of inflammatory infiltrate or presence of fraying of basal keratinocytes may differentiate these two conditions. Objective: In this study, we aimed to confirm these observations. Methods: We reviewed 13 cases of direct immunofluorescence-confirmed epidermolysis bullosa acquisita and 19 cases of direct immunofluorescence-confirmed bullous pemphigoid, all with a subepidermal blister in the routinely processed specimen. The gold standard for diagnosis of epidermolysis bullosa acquisita vs bullous pemphigoid was taken to be identification of immune deposits on the dermal side (‘floor’ for epidermolysis bullosa acquisita) or the epidermal side (‘roof’ for bullous pemphigoid) of the salt-split direct immunofluorescence specimen. Our tests to distinguish epidermolysis bullosa acquisita from bullous pemphigoid on the routinely processed biopsy included periodic acid–Schiff basement membrane on the blister roof, neutrophilic infiltrate, lack of eosinophilic infiltrate, and absence of keratinocyte fraying. Results: Sensitivity and specificity for each test were as follows: periodic acid–Schiff staining of roof (sensitivity 25%, specificity 95%), neutrophilic infiltrate (sensitivity 54%, specificity 74%), lack of eosinophilic infiltrate (sensitivity 92%, specificity 68%), and absence of keratinocyte fraying (sensitivity 62%, specificity 58%). Conclusions: Features in the routinely processed biopsy were unable to reliably distinguish between epidermolysis bullosa acquisita and bullous pemphigoid. Direct immunofluorescence on salt-split skin remains the standard for differentiation.

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