Esophageal mucosal mast cell infiltration and changes in segmental smooth muscle contraction in noncardiac chest pain

2014 ◽  
Vol 28 (6) ◽  
pp. 512-519 ◽  
Author(s):  
S. W. Park ◽  
H. Lee ◽  
H. J. Lee ◽  
H. Chung ◽  
J. C. Park ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Chest Pain ◽  
Muscle Contraction ◽  
Smooth Muscle Contraction ◽  
Cell Infiltration ◽  
Mucosal Mast Cell ◽  
Noncardiac Chest Pain

scholarly journals Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain

Gut and Liver ◽  
2016 ◽  
Vol 10 (1) ◽  
pp. 152 ◽  
Author(s):  
Keol Lee ◽  
Hee Jin Kwon ◽  
In Young Kim ◽  
Kwai Han Yoo ◽  
Seulkee Lee ◽  
...  
Keyword(s):  
Mast Cell ◽  
Chest Pain ◽  
Cell Infiltration ◽  
Noncardiac Chest Pain

Mast Cell Effects on Esophageal Smooth Muscle and their Potential Role in Eosinophilic Esophagitis and Achalasia

2020 ◽  
Author(s):  
Melissa R Nelson ◽  
Xi Zhang ◽  
Zui Pan ◽  
Stuart Jon Spechler ◽  
Rhonda F. Souza
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Mast Cells ◽  
Muscle Contraction ◽  
Eosinophilic Esophagitis ◽  
Muscularis Propria ◽  
Smooth Muscle Contraction ◽  
Enteric Neurons ◽  
Mast Cell Activation ◽  
Parkinson’S Diseases

Mast cells and eosinophils are the key effector cells of allergic disorders. Although most studies on eosinophilic esophagitis (EoE), an allergic disorder of the esophagus, have focused on the role of eosinophils, recent studies suggest a major role for mast cells in causing the clinical manifestations of this disease. Cellular and animal studies have demonstrated that mast cells can cause esophageal muscle cells to proliferate and differentiate into a more contractile phenotype, and that mediators released by degranulating mast cells such as tryptase and histamine can activate smooth muscle contraction pathways. Thus, activated mast cells in the esophageal muscularis propria might cause esophageal motility abnormalities, including the failure of lower esophageal sphincter relaxation typical of achalasia. In addition, mast cells have been implicated in the pathogenesis of a number of neurodegenerative disorders of the central nervous system such as Alzheimer's and Parkinson's diseases, because degranulating mast cells release pro-inflammatory and cytotoxic mediators capable of damaging neurons. Such mast cell degranulation in the myenteric plexus of the esophagus could cause the loss of enteric neurons that characterizes achalasia. In this report, we review the molecular mechanisms of esophageal smooth muscle contraction, and how mast cells products might affect that muscle and cause neurodegeneration in the esophagus. Based on these data, we present our novel, conceptual model for an allergy-induced form of achalasia mediated by mast cell activation in the esophageal muscularis propria.

Heterogeneity of mucosal mast cell infiltration in subgroups of patients with esophageal chest pain

2014 ◽  
Vol 26 (6) ◽  
pp. 786-793 ◽  
Author(s):  
H. Lee ◽  
H. Chung ◽  
J. C. Park ◽  
S. K. Shin ◽  
S. K. lee ◽  
...  
Keyword(s):  
Mast Cell ◽  
Chest Pain ◽  
Cell Infiltration ◽  
Mucosal Mast Cell

A Guinea Pig Model for Study of Bladder Mast Cell Function: Histamine Release and Smooth Muscle Contraction

1990 ◽  
Vol 144 (5) ◽  
pp. 1293-1300 ◽  
Author(s):  
Mads M. Christensen ◽  
Ingegerd Keith ◽  
Patsy R. Rhodes ◽  
Frank M. Graziano ◽  
Paul O. Madsen ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Contraction ◽  
Histamine Release ◽  
Cell Function ◽  
Smooth Muscle Contraction ◽  
Pig Model ◽  
Guinea Pig Model
Sign in / Sign up

Export Citation Format

Share Document