scholarly journals Liraglutide changes body composition and lowers added sugar intake in overweight persons with insulin pump‐treated type 1 diabetes

2021 ◽  
Author(s):  
Signe Schmidt ◽  
Christian Seerup Frandsen ◽  
Thomas Fremming Dejgaard ◽  
Dorte Vistisen ◽  
Thórhallur Halldórsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Body Composition ◽  
Insulin Pump ◽  
Added Sugar ◽  
Sugar Intake

scholarly journals Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1752
Author(s):  
Natalie S. The ◽  
Sarah C. Couch ◽  
Elaine M. Urbina ◽  
Jamie L. Crandell ◽  
Angela D. Liese ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Arterial Stiffness ◽  
Body Mass ◽  
Augmentation Index ◽  
Z Score ◽  
Linear Regression Models ◽  
Added Sugar ◽  
Sugar Intake

The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association.

scholarly journals Association between change in self-reported sugar intake and a sugar biomarker (δ13C) in children at increased risk for type 1 diabetes

2020 ◽  
Vol 9 ◽  
Author(s):  
Martha M. Henze ◽  
Elizabeth A. Bemis ◽  
Jennifer A. Seifert ◽  
Randi K. Johnson ◽  
Fran Dong ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Prospective Cohort ◽  
Intervention Study ◽  
Added Sugar ◽  
Sugar Intake ◽  
Time Points ◽  
Increased Risk ◽  
Dietary Sugar

Abstract We examined whether change in added sugar intake is associated with change in δ13C, a novel sugar biomarker, in thirty-nine children aged 5–10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δ13C in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake was associated with change in the δ13C biomarker, where for every 1-g increase in added sugar intake between the two time points, there was an increase in δ13C of 0⋅0082 (P = 0⋅0053), independent of change in HbA1c and δ15N. The δ13C biomarker may be used as a measure of compliance in an intervention study of children under the age of 10 years who are at increased risk for type 1 diabetes, in which the goal was to reduce dietary sugar intake.

693-P: Oxidative–Antioxidant Balance after Maximum Intensity Exercise in Men with Type 1 Diabetes Treated with a Personal Insulin Pump vs. Healthy Control

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 693-P
Author(s):  
BARTłOMIEJ MATEJKO ◽  
ŁUKASZ TOTA ◽  
MAłGORZATA MORAWSKA ◽  
SANDRA MROZINSKA ◽  
WANDA PILCH ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Pump ◽  
Maximum Intensity ◽  
Healthy Control

Factors influencing adherence among youth with Type-1-Diabetes Mellitus - the Hungarian case

2020 ◽  
Vol 16 ◽  
Author(s):  
Beáta Erika Nagy ◽  
Brigitta Munkácsi ◽  
Karolina Eszter Kovács
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Birth Order ◽  
Insulin Pump ◽  
Demographic Variables ◽  
Insulin Pump Therapy ◽  
Factors Influencing ◽  
Group Comparisons

Background & Introduction: Due to the increasing prevalence of type-1-diabetes an increasing number of studies draws investigation draws attention to its psychological effects and long-term consequences. As Type 1 Diabetes Mellitus is a chronic, non-curable, yet maintanable condition, with the affected children and their families facing a lifelong challenge. Our research focuses on the factors influencing adherence. Methods & Results: The adherence of youth was examined in a sample involving 114 patients treated in the Medical and Health Science Centre at the University of Debrecen by employing a new adherence questionnaire (DAQ abbreviated version, Munkácsi et al, 2019) (DAF 2017; N=114). The influence of socio-demographic variables and those related to the disease (age at the diagnosis, time elapsed since diagnosis, method of treatment, the time elapsed since the use of the pump) were measured by linear regression. Furthermore, the between-group comparisons were made by independent sample t-tests and variance analysis. The investigation was carried out between September 2017 and May 2018. The effect of using insulin pump as therapy is significant and positive (0.36. p=0.045). The adherence of the patients using insulin pump is higher while the effect of the age at the diagnosis has a significantly negative effect (-.247, p=0.035). Thus, earlier detection of the disease may lead to a higher level of adherence. The effects of the socio-demographic variables (gender, family structure, educational level, type of the settlement, owning sibling and birth order) were not significant (p>0.05). Regarding the between-group comparisons, a significant difference could be pointed out concerning the siblings and birth-order as the adherence of the those with siblings was higher (p=0.044). Moreover, concerning insulin pump therapy, the adherence of patients using pump was significantly better (p=0.048). Also, regarding the age of the diagnosis, the adherence of those diagnosed before 12 was seemingly higher (p=0.039). Concerning the other socio-demographical and disease-related variables, no significant differences could be detected. Conclusions: The results suggest that the treatment has an outstanding role in the adherence of the disease. Moreover, the role of the appropriate treatment, living conditions as well as the early diagnosis is relevant.

Glycemic Control in Transition‐Aged Versus Early Adults with Type 1 Diabetes and the Effect of a Government‐Funded Insulin Pump Program

2021 ◽  
Author(s):  
Shane P Mooney ◽  
Gillian L Booth ◽  
Rayzel Shulman ◽  
Yingbo Na ◽  
Alanna Weisman ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Pump

scholarly journals Pump It Up! A randomized clinical trial to optimize insulin pump self-management behaviors in adolescents with type 1 diabetes

2021 ◽  
Vol 102 ◽  
pp. 106279
Author(s):  
Holly K. O'Donnell ◽  
Tim Vigers ◽  
Suzanne Bennett Johnson ◽  
Laura Pyle ◽  
Nancy Wright ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Type 1 Diabetes ◽  
Randomized Clinical Trial ◽  
Insulin Pump ◽  
Self Management ◽  
Management Behaviors

scholarly journals The effectiveness of running virtual clinics as part of insulin pump services for patients with type 1 diabetes

2021 ◽  
Vol 3 ◽  
pp. 100083
Author(s):  
Beth Mumford ◽  
Victoria Oldham ◽  
Dawn Lee ◽  
Julie Jones ◽  
Gautam Das
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Pump

scholarly journals Differential Expression of Inflammatory Markers in Hypoglycemia Unawareness Associated with Type 1 Diabetes: A Case Report

2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Yousef Al Zoubi ◽  
Bashair M. Mussa ◽  
Ankita Srivastava ◽  
Abdul Khader Mohammed ◽  
Elamin Abdelgadir ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Report ◽  
Differential Expression ◽  
Insulin Pump ◽  
Mrna Level ◽  
Insulin Injection ◽  
Hypoglycemia Unawareness ◽  
Tnf Α ◽  
Ifn Γ

The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-α, IL-1β, IL-6, and IFN-γ in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1β, IL-6, and IFN-γ in T1DM patient with HU. However, the mRNA level of TNF-α showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.

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