scholarly journals Fasting oxyntomodulin, glicentin, and gastric inhibitory polypeptide levels are associated with activation of reward‐ and attention‐related brain centres in response to visual food cues in adults with obesity: A cross‐sectional functional MRI study

2021 ◽  
Author(s):  
Nikolaos Perakakis ◽  
Olivia M. Farr ◽  
Christos S. Mantzoros
Keyword(s):  
Functional Mri ◽  
Gastric Inhibitory Polypeptide ◽  
Food Cues ◽  
Cross Sectional ◽  
Mri Study ◽  
Visual Food Cues

Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes

2005 ◽  
Vol 4 (10) ◽  
pp. 618-626 ◽  
Author(s):  
Maria A Rocca ◽  
Bruno Colombo ◽  
Andrea Falini ◽  
Angelo Ghezzi ◽  
Vittorio Martinelli ◽  
...  
Keyword(s):  
Functional Mri ◽  
Cross Sectional ◽  
Disease Phenotypes ◽  
Cortical Adaptation ◽  
Mri Study

A cross-sectional and follow-up functional MRI study with a working memory task in adolescent anorexia nervosa

2010 ◽  
Vol 48 (14) ◽  
pp. 4111-4116 ◽  
Author(s):  
Josefina Castro-Fornieles ◽  
Xavier Caldú ◽  
Susana Andrés-Perpiñá ◽  
Luisa Lázaro ◽  
Nuria Bargalló ◽  
...  
Keyword(s):  
Working Memory ◽  
Anorexia Nervosa ◽  
Functional Mri ◽  
Memory Task ◽  
Cross Sectional ◽  
Adolescent Anorexia Nervosa ◽  
Mri Study

Neural correlates of voice gender and message framing in advertising: A functional MRI study.

2017 ◽  
Vol 10 (4) ◽  
pp. 121-136 ◽  
Author(s):  
Luis-Alberto Casado-Aranda ◽  
Juan Sánchez-Fernández ◽  
Francisco J. Montoro-Ríos
Keyword(s):  
Functional Mri ◽  
Message Framing ◽  
Neural Correlates ◽  
Mri Study

scholarly journals Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mojca Jensterle ◽  
Simona Ferjan ◽  
Tadej Battelino ◽  
Jernej Kovač ◽  
Saba Battelino ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Neural Response ◽  
Taste Perception ◽  
Taste Bud ◽  
Controlled Clinical Trial ◽  
Food Cues ◽  
Link Type ◽  
Visual Food Cues ◽  
Taste Bud Cells

Abstract Background Preclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Whether any weight-reducing effects of GLP-1 receptor agonists are mediated through the modulation of taste perception is currently unknown. Methods and analysis This is an investigator-initiated, randomized single-blind, placebo-controlled clinical trial. We will enrol 30 women with obesity and polycystic ovary syndrome (PCOS). Participants will be randomized in a 1:1 ratio to either semaglutide 1.0 mg or placebo for 16 weeks. The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry. Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake. Discussion This is the first study to investigate the role of semaglutide on taste perception, along with a neural response to visual food cues in reward processing regions. The study may identify the tongue and the taste perception as a novel target for GLP-1 receptor agonists. Ethics and disseminations The study has been approved by the Slovene National Medical Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Results will be submitted for publication in an international peer-reviewed scientific journal. Trial registration ClinicalTrials.govNCT04263415. Retrospectively registered on 10 February 2020

Acute diet soda consumption alters brain responses to food cues in humans: A randomized, controlled, cross-over pilot study

2021 ◽  
pp. 026010602199375
Author(s):  
Olivia M. Farr
Keyword(s):  
Pilot Study ◽  
Epidemiological Studies ◽  
Potential Mechanism ◽  
Food Cues ◽  
Diet Soda ◽  
Brain Responses ◽  
Dorsolateral Prefrontal ◽  
Carbonated Water ◽  
Soda Consumption ◽  
Visual Food Cues

Background: Diet soda consumption has frequently been linked to obesity and its comorbidities in epidemiological studies. Whether this link is causal and a potential mechanism remains to be determined. Aim/Methods: This randomized, cross-over, controlled pilot study sought to determine whether there may be changes in reward-related brain activations to visual food cues after acute consumption of diet soda versus regular soda or carbonated water using functional magnetic resonance imaging. Results: Diet soda as compared to carbonated water consumption increased activation of reward-related caudate to highly versus less desirable food cues. Diet soda as compared to regular soda increased reward-related insula and decreased activation of cognitive control-related dorsolateral prefrontal cortex to food cues versus non-food cues. No changes in ratings of hunger an hour after beverage consumption were observed. Conclusions: These results may suggest a potential mechanism for diet soda to increase food palatability through activation of the reward system and suppression of inhibitory control that remains to be confirmed by future studies.

scholarly journals The processing of visual food cues during bitter aftertaste perception in females with high vs. low disgust propensity: an fMRI study

2021 ◽  
Author(s):  
Anne Schienle ◽  
Albert Wabnegger
Keyword(s):  
Personality Trait ◽  
Visual Cues ◽  
Critical Role ◽  
Relevant Information ◽  
Anterior Cingulate ◽  
Conflict Monitoring ◽  
Food Cues ◽  
Sweet Food ◽  
Visual Food Cues ◽  
Disgust Propensity

AbstractAn extremely bitter taste can signal food spoilage, and therefore typically elicits disgust. The present cross-modal functional magnetic resonance imaging experiment investigated whether the personality trait ‘disgust propensity’ (DP; temporally stable tendency to experience disgust across different situations) has an influence on the processing of visual food cues during bitter aftertaste perception. Thirty females with high DP and 30 females with low DP viewed images depicting sweet food (e.g., cakes, ice cream) and vegetables, once in combination with an extremely bitter aftertaste (concentrated wormwood tea), and once with a neutral taste (water). Females highly prone to disgust (compared to low disgust-prone females) showed increased activity in the anterior cingulate cortex (ACC) and increased mPFC-insula connectivity when presented with the mismatch of a bitter aftertaste and visual cues of sweet food. The ACC is involved in conflict monitoring and is strongly interconnected with insular areas. This connection plays a critical role in awareness of changes in homeostatic states. Our findings indicate that the personality trait DP is associated with cross-modal integration processes of disgust-relevant information. Females high in DP were more alert to food-related sensory mismatch (pleasant visual features, aversive taste) than females low in DP.

Reorganisation of the sensorimotor cortex after early focal brain lesion: a functional MRI study in monozygotic twins

Neuroreport ◽  
2001 ◽  
Vol 12 (7) ◽  
pp. 1335-1340 ◽  
Author(s):  
Giovanni Cioni ◽  
Domenico Montanaro ◽  
Michela Tosetti ◽  
Raffaello Canapicchi ◽  
Brunello Ghelarducci
Keyword(s):  
Functional Mri ◽  
Sensorimotor Cortex ◽  
Brain Lesion ◽  
Monozygotic Twins ◽  
Focal Brain Lesion ◽  
Mri Study
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