scholarly journals Metformin‐associated prevention of weight gain in insulin‐treated type 2 diabetic patients cannot be explained by decreased energy intake: A post hoc analysis of a randomized placebo‐controlled 4.3‐year trial

2017 ◽  
Vol 20 (1) ◽  
pp. 219-223 ◽  
Author(s):  
Mattijs Out ◽  
Ida Miedema ◽  
Harriët Jager‐Wittenaar ◽  
Cees van der Schans ◽  
Wim Krijnen ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Intake ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
Type 2 Diabetic

Contribution of change in glycosylated haemoglobin to insulin-associated weight gain: results of a longitudinal study in type 2 diabetic patients

Endocrine ◽  
2010 ◽  
Vol 39 (2) ◽  
pp. 190-197 ◽  
Author(s):  
H. J. Jansen ◽  
J. C. Hendriks ◽  
B. E. de Galan ◽  
G. Penders ◽  
C. J. Tack ◽  
...  
Keyword(s):  
Weight Gain ◽  
Longitudinal Study ◽  
Glycosylated Haemoglobin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals The energy intake modulates the association of the –55CT polymorphism of UCP3 with body weight in type 2 diabetic patients

2013 ◽  
Vol 38 (6) ◽  
pp. 873-877 ◽  
Author(s):  
E Lapice ◽  
A Monticelli ◽  
S Cocozza ◽  
M Pinelli ◽  
A Giacco ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Intake ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals ‘Glucose control-related’ and ‘non-glucose control-related’ effects of insulin on weight gain in newly insulin-treated type 2 diabetic patients

2005 ◽  
Vol 94 (6) ◽  
pp. 931-937 ◽  
Author(s):  
A. Sallé ◽  
M. Ryan ◽  
G. Guilloteau ◽  
B. Bouhanick ◽  
G. Berrut ◽  
...  
Keyword(s):  
Weight Gain ◽  
Glucose Control ◽  
Body Water ◽  
Fat Free Mass ◽  
Diabetic Patients ◽  
Related Effect ◽  
Type 2 Diabetic Patients ◽  
Total Body ◽  
Type 2 Diabetic

Insulin use is common in type 2 diabetes and is frequently accompanied by weight gain, the composition of which is poorly understood. The present study evaluates insulin-induced body composition changes. Body weight and composition of thirty-two type 2 diabetic patients undergoing their first 12 months of insulin therapy were compared with those observed in thirty-two type 2 diabetic patients previously treated on insulin (minimum 1 year). Body composition was determined by simultaneous body water spaces (bioelectrical impedance analysis) and body density measurements. After 6 months, glycosylated Hb (HbA1c) significantly improved in the newly treated group (P<0·0001), but remained stable in those treated previously. HbA1c did not differ between 6 and 12 months in the two groups. Body weight significantly (P=0·04) changed over 12 months in those newly treated only (+2·8 kg), essentially comprising fat-free mass (P=0·044). Fat mass remained unchanged (P=0·85) as did total body water, while extracellular: total body water ratio tended to increase in those newly treated (P=0·059). Weight changes correlated with HbA1c changes (R2 0·134, P=0·002) in the initial 6 months only. Insulin therapy leads to weight gain (2·8 kg), predominantly fat-free mass, over 12 months. After 6 months, newly treated patients continued gaining weight despite an unchanged HbA1c, suggesting the potential anabolic role of insulin in subsequent gains. Therefore, in the initial 6 months, weight gain can be attributed to a ‘glucose control-related effect’ and further gain appears to be due to a ‘non-glucose control-related’ effect of insulin treatment.

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