scholarly journals The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro

2016 ◽  
Vol 19 (2) ◽  
pp. 257-265 ◽  
Author(s):  
Attilio Pingitore ◽  
Edward S. Chambers ◽  
Thomas Hill ◽  
Inmaculada Ruz Maldonado ◽  
Bo Liu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Short Chain Fatty Acid ◽  
Cell Function ◽  
Human Islets ◽  
Chain Fatty Acid ◽  
Short Chain

Short-chain fatty acid transport and its effects on ion transport by rabbit cecum

1987 ◽  
Vol 253 (2) ◽  
pp. G171-G178
Author(s):  
M. Hatch
Keyword(s):  
Fatty Acid ◽  
Short Chain Fatty Acid ◽  
Short Circuit ◽  
Basolateral Membrane ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Bathing Solution ◽  
Fatty Acid Transport ◽  
Unexpected Finding

Short-chain fatty acid (SCFA) metabolism and transport were examined in vitro across isolated rabbit cecal epithelia whose primary function is absorption of these solutes. This study shows that although there was some low-level metabolism of SCFAs to ketone bodies by the isolated cecum, a significantly higher oxygen consumption was sustained for a longer time period by tissues incubated in glucose-containing salines. The cecum supported a significant net secretory flux of acetate (J net Ac- = -1.13 +/- 0.13 mu eq X cm-2 X h-1) and propionate (J net Pr- = -0.61 +/- 0.14 mu eq X cm-2 X h-1). This study also shows that glucose significantly enhanced short-circuit current (Isc), tissue conductance (Gt), and sodium transport across this tissue. Neither Ac- nor Pr- enhanced net sodium flux (J net Ac-) but Pr- significantly reduced net chloride flux (J net Cl-), whereas Ac- had no effect. The increase in Isc and Gt observed in the presence of SCFAs was attributable to the presence of SCFA in the serosal bathing solution alone. To explain the latter finding and the unexpected finding of SCFA secretion, the existence of an electrogenic anion (HCO3-) secretory pathway is postulated. It is suggested that this system can accommodate SCFAs in vitro and that it is a Na+-dependent system located on the basolateral membrane of the cecal cell.

In Vitro Batch Fecal Fermentation Comparison of Gas and Short-Chain Fatty Acid Production Using “Slowly Fermentable” Dietary Fibers

2011 ◽  
Vol 76 (5) ◽  
pp. H137-H142 ◽  
Author(s):  
Amandeep Kaur ◽  
Devin J. Rose ◽  
Pinthip Rumpagaporn ◽  
John A. Patterson ◽  
Bruce R. Hamaker
Keyword(s):  
Fatty Acid ◽  
Acid Production ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Dietary Fibers ◽  
Fatty Acid Production
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