scholarly journals Artemisia dracunculusL. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture

2014 ◽  
Vol 16 (8) ◽  
pp. 728-738 ◽  
Author(s):  
B. Vandanmagsar ◽  
K. R. Haynie ◽  
S. E. Wicks ◽  
E. M. Bermudez ◽  
T. M. Mendoza ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Human Skeletal Muscle ◽  
Muscle Culture ◽  
Inflammatory Signalling

scholarly journals Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment

Diabetes ◽  
2000 ◽  
Vol 49 (5) ◽  
pp. 768-774 ◽  
Author(s):  
A. D. Baron ◽  
M. Tarshoby ◽  
G. Hook ◽  
E. N. Lazaridis ◽  
J. Cronin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Glucose Uptake ◽  
Human Skeletal Muscle ◽  
Muscle Perfusion ◽  
Capillary Recruitment

scholarly journals Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling

Diabetes ◽  
2017 ◽  
Vol 66 (6) ◽  
pp. 1501-1510 ◽  
Author(s):  
Kim A. Sjøberg ◽  
Christian Frøsig ◽  
Rasmus Kjøbsted ◽  
Lykke Sylow ◽  
Maximilian Kleinert ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Human Skeletal Muscle ◽  
Microvascular Perfusion ◽  
Molecular Signaling ◽  
Skeletal Muscle Insulin Sensitivity

scholarly journals Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle

2015 ◽  
Vol 309 (4) ◽  
pp. E388-E397 ◽  
Author(s):  
Adam J. Trewin ◽  
Leonidas S. Lundell ◽  
Ben D. Perry ◽  
Kim Vikhe Patil ◽  
Alexander V. Chibalin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Repeated Measures ◽  
Insulin Action ◽  
Human Skeletal Muscle ◽  
Protein Signaling ◽  
Insulin Stimulation ◽  
Double Blind ◽  
Exercise Induced ◽  
Muscle Biopsies

—Reactive oxygen species (ROS) produced in skeletal muscle may play a role in potentiating the beneficial responses to exercise; however, the effects of exercise-induced ROS on insulin action and protein signaling in humans has not been fully elucidated. Seven healthy, recreationally active participants volunteered for this double-blind, randomized, repeated-measures crossover study. Exercise was undertaken with infusion of saline (CON) or the antioxidant N-acetylcysteine (NAC) to attenuate ROS. Participants performed two 1-h cycling exercise sessions 7–14 days apart, 55 min at 65% V̇o2peak plus 5 min at 85%V̇o2peak, followed 3 h later by a 2-h hyperinsulinemic euglycemic clamp (40 mIU·min−1·m2) to determine insulin sensitivity. Four muscle biopsies were taken on each trial day, at baseline before NAC infusion (BASE), after exercise (EX), after 3-h recovery (REC), and post-insulin clamp (PI). Exercise, ROS, and insulin action on protein phosphorylation were evaluated with immunoblotting. NAC tended to decrease postexercise markers of the ROS/protein carbonylation ratio by −13.5% ( P = 0.08) and increase the GSH/GSSG ratio twofold vs. CON ( P < 0.05). Insulin sensitivity was reduced (−5.9%, P < 0.05) by NAC compared with CON without decreased phosphorylation of Akt or AS160. Whereas p-mTOR was not significantly decreased by NAC after EX or REC, phosphorylation of the downstream protein synthesis target kinase p70S6K was blunted by 48% at PI with NAC compared with CON ( P < 0.05). We conclude that NAC infusion attenuated muscle ROS and postexercise insulin sensitivity independent of Akt signaling. ROS also played a role in normal p70S6K phosphorylation in response to insulin stimulation in human skeletal muscle.

scholarly journals Adipocyte Differentiation-related Protein in Human Skeletal Muscle: Relationship to Insulin Sensitivity

2005 ◽  
Vol 13 (8) ◽  
pp. 1321-1329 ◽  
Author(s):  
Susan A. Phillips ◽  
Charles C. Choe ◽  
Theodore P. Ciaraldi ◽  
Andrew S. Greenberg ◽  
Alice P. S. Kong ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Human Skeletal Muscle ◽  
Adipocyte Differentiation ◽  
Related Protein
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