Effect of the G-protein β3 subunit 825T allele on the change of body adiposity in obese female

2012 ◽  
Vol 15 (3) ◽  
pp. 284-286 ◽  
Author(s):  
I. C. Hwang ◽  
K. K. Kim ◽  
H. Y. Ahn ◽  
H. S. Suh ◽  
S. W. Oh
Keyword(s):  
G Protein ◽  
Body Adiposity ◽  
Obese Female ◽  
825T Allele

The G Protein β3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype

2003 ◽  
Vol 4 (4) ◽  
pp. 337-342
Author(s):  
C. Naber ◽  
R. Erbel ◽  
W. Siffert
Keyword(s):  
G Protein ◽  
Subunit Gene ◽  
Thrifty Genotype ◽  
825T Allele

scholarly journals Increased Tumor Growth in Mice with Diet-Induced Obesity: Impact of Ovarian Hormones

Endocrinology ◽  
2006 ◽  
Vol 147 (12) ◽  
pp. 5826-5834 ◽  
Author(s):  
Shoshana Yakar ◽  
Nomeli P. Nunez ◽  
Patricia Pennisi ◽  
Pnina Brodt ◽  
Hui Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Tumor Growth ◽  
Glucose Intolerance ◽  
Tumor Development ◽  
Tumor Growth Rate ◽  
Obese Mice ◽  
Female Mice ◽  
Diet Induced Obesity ◽  
Body Adiposity ◽  
Obese Female

Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.

scholarly journals Worldwide Ethnic Distribution of the G Protein β3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals

1999 ◽  
Vol 10 (9) ◽  
pp. 1921-1930
Author(s):  
WINFRIED SIFFERT ◽  
PETER FORSTER ◽  
KARL-HEINZ JÖCKEL ◽  
DAVID A. MVERE ◽  
BERND BRINKMANN ◽  
...  
Keyword(s):  
G Protein ◽  
Young Male ◽  
Normal Weight ◽  
Allele Frequencies ◽  
Gene Encoding ◽  
Black Africans ◽  
Black African ◽  
South Africans ◽  
825T Allele ◽  
C825t Polymorphism

Abstract. Recently, it was demonstrated that one allele (825T) of the gene encoding the G protein β3 subunit (GNB3) is associated with hypertension in Germans. This study investigates a possible association with obesity in young male Germans, Chinese, and black South Africans with low, intermediate, and high 825T allele frequencies, respectively. In each of these three distinct cohorts, the 825T allele frequency was increased significantly in overweight (body mass index [BMI] ≥25 kg/m2) and obese individuals (BMI >27 kg/m2) compared to those with normal weight. The 825T allele frequencies in these three BMI groups were, respectively, 29.5, 39.3, and 47.7% in Germans, 46.8, 53.9, and 58.6% in Chinese, and 83.1, 87.7, and 90.9% in South Africans. In each of these three distinct groups, the 825T allele was significantly associated with obesity with odds ratios between 2 and 3. More urban than rural black Africans were overweight despite similar 825T allele frequencies in both populations, which underscores the role of both genetic and environmental factors. BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity. Genotyping of 5254 individuals from 55 native population samples from Africa, the Americas, Europe, Asia, Australia, and New Guinea demonstrated highest 825T allele frequencies in black Africans (82%) and intermediate values in east Asians (47%). It is anticipated that high frequencies of the 825T allele in Africans and Asians may contribute to an obesity and hypertension epidemic if Westernization of lifestyles continues.

scholarly journals Increased frequency of G-protein β3-subunit 825T allele in dialyzed patients with type 2 diabetes

1999 ◽  
Vol 55 (4) ◽  
pp. 1247-1250 ◽  
Author(s):  
Martin Blüthner ◽  
Susanne Schmidt ◽  
Winfried Siffert ◽  
Heidrun Knigge ◽  
Peter Nawroth ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
G Protein ◽  
825T Allele

G protein ??3 subunit 825T allele is associated with depression in young, healthy subjects

Neuroreport ◽  
2003 ◽  
pp. 531-533 ◽  
Author(s):  
Michael S. Exton ◽  
Mike Artz ◽  
Winfried Siffert ◽  
Manfred Schedlowski
Keyword(s):  
G Protein ◽  
Healthy Subjects ◽  
825T Allele

scholarly journals Association between Polymorphisms in Genes Related to Common Adult Diseases and Fetal Growth

2009 ◽  
Vol 3 ◽  
pp. CMPed.S2154 ◽  
Author(s):  
Hisao Osada
Keyword(s):  
G Protein ◽  
Genetic Polymorphisms ◽  
Fetal Growth ◽  
Later Life ◽  
Growth Efficiency ◽  
825T Allele ◽  
Close Relationship ◽  
Genomic Regions ◽  
Size At Birth

A close relationship between size at birth and occurrence of common adult diseases has been reported. As an explanation of this relationship, it has been hypothesized that the thrifty genotypes cause changes in growth efficiency during fetal period and diseases in later life. In the present study, we examined the association of fetal growth with genetic polymorphisms within the IGF2-INS-TH region and in the G protein gene. Analysis of the genes in the IGF2-INS-TH region suggests that thrifty genotype has the effect of accelerating fetal growth, but at the same time a genomic imprinting mechanism is also involved. Analysis of the G protein β3 subunit gene unveiled that the 825T allele in the mother may exert influence on fetal metabolic environment. By extending the analysis to other genomic regions related to common adult diseases using the same technique, the detailed role of genetic polymorphisms may be elucidated.

Haemodynamic characterization of young normotensive men carrying the 825T-allele of the G-protein ß3 subunit

2001 ◽  
Vol 11 (6) ◽  
pp. 461-470 ◽  
Author(s):  
Rafael F. Schäfers ◽  
Jens Nürnberger ◽  
Angelika Rütz ◽  
Winfried Siffert ◽  
René R. Wenzel ◽  
...  
Keyword(s):  
G Protein ◽  
825T Allele

G-protein β3 subunit 825T allele and hypertension

2003 ◽  
Vol 5 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Winfried Siffert
Keyword(s):  
G Protein ◽  
825T Allele
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