scholarly journals Association between Polymorphisms in Genes Related to Common Adult Diseases and Fetal Growth

2009 ◽  
Vol 3 ◽  
pp. CMPed.S2154 ◽  
Author(s):  
Hisao Osada
Keyword(s):  
G Protein ◽  
Genetic Polymorphisms ◽  
Fetal Growth ◽  
Later Life ◽  
Growth Efficiency ◽  
825T Allele ◽  
Close Relationship ◽  
Genomic Regions ◽  
Size At Birth

A close relationship between size at birth and occurrence of common adult diseases has been reported. As an explanation of this relationship, it has been hypothesized that the thrifty genotypes cause changes in growth efficiency during fetal period and diseases in later life. In the present study, we examined the association of fetal growth with genetic polymorphisms within the IGF2-INS-TH region and in the G protein gene. Analysis of the genes in the IGF2-INS-TH region suggests that thrifty genotype has the effect of accelerating fetal growth, but at the same time a genomic imprinting mechanism is also involved. Analysis of the G protein β3 subunit gene unveiled that the 825T allele in the mother may exert influence on fetal metabolic environment. By extending the analysis to other genomic regions related to common adult diseases using the same technique, the detailed role of genetic polymorphisms may be elucidated.

scholarly journals Pathophysiology of placenta and fetus in diabetes mellitus

2018 ◽  
Vol 67 (6) ◽  
pp. 79-92
Author(s):  
Roman V. Kapustin ◽  
Alexandra R. Onopriychuk ◽  
Olga N. Arzhanova ◽  
Victoria O. Polyakova ◽  
Elena N. Alekseyenkova
Keyword(s):  
Diabetes Mellitus ◽  
Fetal Growth ◽  
Later Life ◽  
Steady Increase ◽  
Therapeutic Approaches ◽  
Abnormal Growth ◽  
New Therapeutic Approaches ◽  
Global Population ◽  
And Child Health

Currently, there is a steady increase in the incidence of diabetes mellitus (DM) in the global population, which causes an increase in maternal and perinatal mortality. Children born to mothers with DM have a high risk of not only congenital abnormalities, but also cardiovascular and metabolic disorders in later life. Fetal growth is determined by both the metabolic and nutritional status of the mother, and the placental nutrient transfer capacity. Pregnancy complicated by DM is associated not only with overgrowth of the fetus, but also with the excess deposition of metabolites in the placenta. The role of disorders of carbohydrate metabolism, obesity and other factors in relation to the function of the placenta and fetal growth remains not fully understood. This review provides an overview of the literature on the placental complex status in pregnancy complicated by obesity, as well as pre-gestational and gestational types of DM. The focus is on three key substrates in these conditions: glucose, lipids, and amino acids, and their influence on placental metabolic activity and on the fetus. Improved knowledge of morphology and understanding of changes in the function of the placenta that lead to abnormal growth of the fetus will allow for the development of new therapeutic approaches to improve the outcomes of pregnancy, maternal and child health.

The G Protein β3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype

2003 ◽  
Vol 4 (4) ◽  
pp. 337-342
Author(s):  
C. Naber ◽  
R. Erbel ◽  
W. Siffert
Keyword(s):  
G Protein ◽  
Subunit Gene ◽  
Thrifty Genotype ◽  
825T Allele

Introduction: Kinship Bereavement in Later Life

1997 ◽  
Vol 35 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Brian De Vries
Keyword(s):  
Adult Child ◽  
Later Life ◽  
Short Term ◽  
Traumatic Grief ◽  
Death Of A Parent ◽  
De Vries ◽  
Longitudinal Effects ◽  
Analysis Of Variation

This article introduces a volume devoted to the examination of later-life bereavement: an analysis of variation in cause, course, and consequence. Six articles address and represent this variation and comprise this volume: 1) Prigerson et al. present case histories of the traumatic grief of spouses; 2) Hays et al. highlight the bereavement experiences of siblings in contrast to those spouses and friends; 3) Moss et al. address the role of gender in middle-aged children's responses to parent death; 4) Bower focuses on the language adopted by these adult children in accepting the death of a parent; 5) de Vries et al. explore the long-term, longitudinal effects on the psychological and somatic functioning of parents following the death of an adult child; and 6) Fry presents the short-term and longitudinal reactions of grandparents to the death of a grandchild. A concluding article is offered by de Vries stressing both the unique and common features of these varied bereavement experiences touching on some of the empirical issues and suggesting potential implications and applications.

Lineages

2018 ◽  
Author(s):  
Ruth Gamble
Keyword(s):  
Thirteenth Century ◽  
Buddhist Tradition ◽  
Close Relationship

Chapter 2 examines lineages in Tibetan society and the Buddhist tradition and explains how they influenced the development of Tibet’s reincarnation lineages. It begins by explaining the role of family lineages in thirteenth-century Tibet, describing how lineages helped form identities, created links between people, and served as a mechanism for inheritance. It then examines the three main forms of Buddhist lineages—monastic, Mahāyāna, and Tantric—and shows how these lineages were often intermingled with Tibetan family lineages and inheritance practices. The chapter ends by outlining how lineages associated with manifestation, particularly lineages associated with Avalokiteśvara, underpinned claims by Tibetans to be the manifestation of this bodhisattva and other celestial beings. This chapter also explains how the Karmapas’ reincarnation lineage, traditions, and institutions were presented not as a break from other lineages but as an extension of them, and it highlights the close relationship between lineages and specific places.

Processing the Future

2018 ◽  
Author(s):  
Martin Giraudeau
Keyword(s):  
Venture Capital ◽  
Diagnostic Techniques ◽  
Business Administration ◽  
Knowledge Practices ◽  
Project Appraisal ◽  
Development Corporation ◽  
Close Relationship ◽  
Administrative Procedures ◽  
American Research

This chapter is an analysis of the project appraisal procedures in place at American Research and Development Corporation (ARD) between 1946 and 1973, under the management of Georges F. Doriot. It shows the importance of knowledge technologies and administrative procedures in the way the venture capital company dealt with uncertain futures. The origins of these knowledge practices are traced back to Georges F. Doriot’s own views on business and more generally to the pragmatist movement in business administration of which he was a member. The conduct of project appraisal at ARD is then observed directly, and this reveals its reliance on a rich set of knowledge and diagnostic techniques as well as administrative procedures. These observations allow for a specification of the nature and role of imagination in the entrepreneurship and venture capital practices examined here—in particular, its close relationship with organized knowledge.

scholarly journals Insights into the role of placenta thickness as a predictive marker of perinatal outcome

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199096
Author(s):  
Xiwen Sun ◽  
Jiayu Shen ◽  
Liquan Wang
Keyword(s):  
Clinical Practice ◽  
Fetal Growth ◽  
Pregnancy Outcomes ◽  
Perinatal Outcome ◽  
Predictive Marker ◽  
Fetal Abnormalities ◽  
The Relationship

The placenta is a transitory organ indispensable for normal fetal maturation and growth. Recognition of abnormal placental variants is important in clinical practice, and a broader understanding of the significance of placental variants would help clinicians better manage affected pregnancies. Increased thickness of the placenta is reported to be a nonspecific finding but it is associated with many maternal and fetal abnormalities, including preeclampsia and abnormal fetal growth. In this review, we address the questions regarding the characteristics of placenta thickness and the relationship between thickened placenta and poor pregnancy outcomes.

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