scholarly journals Temporal trend of small nerve fibre degeneration in people with and without type 2 diabetes mellitus

2021 ◽  
Author(s):  
Linnéa Ekman ◽  
Kaveh Pourhamidi ◽  
Elisabet Englund ◽  
Neil Lagali ◽  
Olov Rolandsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nerve Fibre ◽  
Temporal Trend ◽  
Small Nerve

Corneal nerve fibre damage precedes diabetic retinopathy in patients with Type 2 diabetes mellitus

2013 ◽  
Vol 31 (4) ◽  
pp. 431-438 ◽  
Author(s):  
G. Bitirgen ◽  
A. Ozkagnici ◽  
R. A. Malik ◽  
H. Kerimoglu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Nerve Fibre ◽  
Corneal Nerve

scholarly journals Skin Advanced Glycation End Products among Subjects with Type 2 Diabetes Mellitus with or without Distal Sensorimotor Polyneuropathy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Stella Papachristou ◽  
Kalliopi Pafili ◽  
Grigorios Trypsianis ◽  
Dimitrios Papazoglou ◽  
Konstantinos Vadikolias ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Disability Score ◽  
Perception Threshold ◽  
Sensorimotor Polyneuropathy ◽  
Function Impairment ◽  
Scientific Laboratory ◽  
Small Nerve

Aim of the Study. To examine the correlation between skin AGEs and parameters of distal sensorimotor polyneuropathy (DSPN) in type 2 diabetes mellitus (T2DM). Materials and Methods. We included 132 subjects (88 men) with a mean age of 64.57 years and median T2DM duration of 14.5 years. Skin AGEs were measured with AGE reader mu connect (Diagnoptics) on the dominant arm. The device enables single and automated triplicate measurements: both of these were performed. DSPN was diagnosed through the neuropathy disability score (NDS). Small nerve fibre function was assessed by temperature and pinprick sensation on the foot. Bilateral measurement of the vibration perception threshold (VPT) on the hallux was carried out by using a neurothesiometer (Horwell Scientific Laboratory Supplies). Results. Single and triplicate AGE measurements were positively correlated with each other (Pearson’s correlation coefficient r = 0.991 , 95 % CI = 0.987 -0.994, p < 0.001 ). AGEs were higher among subjects with vs. those without DSPN ( p < 0.001 ). Furthermore, they were higher among subjects with reduced vs. normal temperature sensation ( p < 0.001 ), among subjects with reduced vs. normal pinprick sensation ( p = 0.002 ), among those with abnormal vs. normal monofilament examination ( p < 0.001 ), and among those with abnormal vs. normal VPT ( p < 0.001 ). AGEs were correlated with NDS, VPT, and monofilament score. Conclusions. In T2DM, skin AGEs are increased in the presence of DSPN. This holds true both for large and for small nerve function impairment. Moreover, AGEs are correlated with DSPN severity.

Intraepidermal nerve-fibre density as a biomarker of the course of neuropathy in patients with Type 2 diabetes mellitus

2015 ◽  
Vol 33 (5) ◽  
pp. 650-654 ◽  
Author(s):  
S. Divisova ◽  
E. Vlckova ◽  
I. Srotova ◽  
S. Kincova ◽  
M. Skorna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nerve Fibre ◽  
Fibre Density

Abstract #1214: Decreasing Hypoglycemia Without Compromising Efficacy in an Aging Type 2 Diabetes Mellitus (T2Dm) Population

2015 ◽  
Vol 21 ◽  
pp. 280-281
Author(s):  
Medha Munshi ◽  
Jasvinder Gill ◽  
Jason Chao ◽  
Elena Nikonova ◽  
Andreas Stuhr ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus
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