scholarly journals Discriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study

2015 ◽  
Vol 33 (3) ◽  
pp. 348-355 ◽  
Author(s):  
C. Lorenzo ◽  
A. J. Hanley ◽  
M. J. Rewers ◽  
S. M. Haffner
Keyword(s):  
Insulin Resistance ◽  
Alanine Aminotransferase ◽  
Diabetes Prediction ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Insulin Sensitivity, Insulinemia, and Coronary Artery Disease: The Insulin Resistance Atherosclerosis Study

Diabetes Care ◽  
2004 ◽  
Vol 27 (3) ◽  
pp. 781-787 ◽  
Author(s):  
M. Rewers ◽  
D. Zaccaro ◽  
R. D'Agostino ◽  
S. Haffner ◽  
M. F. Saad ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Insulin Sensitivity ◽  
Artery Disease ◽  
Insulin Resistance Atherosclerosis Study

scholarly journals Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

Diabetologia ◽  
2011 ◽  
Vol 54 (12) ◽  
pp. 3047-3054 ◽  
Author(s):  
R. C. Loopstra-Masters ◽  
S. M. Haffner ◽  
C. Lorenzo ◽  
L. E. Wagenknecht ◽  
A. J. Hanley
Keyword(s):  
Insulin Resistance ◽  
Incident Diabetes ◽  
C Peptide ◽  
Insulin Resistance Atherosclerosis Study ◽  
Ratio Versus

Influence of Insulin Resistance and Adipocytokines on Elevated Serum Alanine Aminotransferase in Obese Patients

2008 ◽  
Vol 39 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rocio Aller ◽  
Olatz Izaola ◽  
Manuel Gonzalez Sagrado ◽  
Rosa Conde ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Obese Patients ◽  
Serum Alanine Aminotransferase

scholarly journals MON-109 Modulator of Gut Barrier, Zonulin Was Associated with Waist to Height Ratio in Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ki Eun Kim ◽  
Ok-Hyang Kim ◽  
Sol Han ◽  
Youn-Ho Sheen ◽  
Soo-Yeon Kim
Keyword(s):  
Insulin Resistance ◽  
Tight Junction ◽  
Alanine Aminotransferase ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Multivariate Linear Regression Analysis ◽  
Z Score ◽  
Height Ratio ◽  
Waist Hip Ratio ◽  
Waist Height Ratio

Abstract Background: Zonulin is the endogenous protein known to control the permeability of intestinal tight junction reversibly. Zonulin is actively engaged in intestinal innate immunity and is over-expressed in autoimmune diseases where tight junction of intestine plays a pivotal role, such as celiac disease, malabsorption disorder, and type 1 diabetes. Waist-Height ratio was well known as one of indices of obesity and also Waist-Hip ratio was known of abdominal obesity. We investigated that the associations among Waist-Height, Waist-Height ratio, and the level of Zonulin by assessing obesity-related biomarkers, such as liver enzymes, lipid profiles, and insulin resistance, in a population of adolescents. Methods: The study included 198 adolescents aged 12-18 years; 92 were overweight/obese and 106 were of normal-weight. We assessed anthropometric and laboratory measures, including body mass index (BMI), BMI z-score, Waist-Height, Waist-Hip ratio, blood pressure, liver enzyme levels, lipid profiles, and insulin sensitivity. Serum Zonulin levels were measured using an enzyme-linked immunosorbent assay. Results: The mean age of the participants was 15.2±2.5 years. Circulating serum Zonulin levels were significantly increased in overweight/obese participants compared with those in normal-weight participants (P=0.042). Zonulin levels were significantly and positively associated with BMI, BMI z-score, alanine aminotransferase levels, triglyceride, fasting insulin, and insulin resistance as indicated by the homeostasis model assessment of insulin resistance (HOMA-IR) (all P<0.05). In multivariate linear regression analysis, alanine aminotransferase (P<0.0001), triglyceride (P<0.0001), and HOMA-IR (P=0.001) contributed independently to circulating Zonulin levels after controlling for the effect of BMI z-score. Zonulin levels were more strongly associated with Waist-Hip ratio rather than Waist-Height ratio. Conclusions: Zonulin was associated with indices of obesity. Waist-Hip ratio was more strongly associated with levels of Zonulin. The positive correlation between these parameters suggests putative pathophysiological mechanism linking Zonulin to metabolic dysfunction in adolescents.

scholarly journals Adherence to the DASH Diet Is Inversely Associated With Incidence of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Diabetes Care ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1434-1436 ◽  
Author(s):  
A. D. Liese ◽  
M. Nichols ◽  
X. Sun ◽  
R. B. D'Agostino ◽  
S. M. Haffner
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Dash Diet ◽  
Insulin Resistance Atherosclerosis Study
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