Interpretation of HbA1c : association with mean cell volume and haemoglobin concentration

2014 ◽  
Vol 31 (11) ◽  
pp. 1387-1392 ◽  
Author(s):  
D. Simmons ◽  
T. Hlaing
Keyword(s):  
Cell Volume ◽  
Haemoglobin Concentration ◽  
Mean Cell Volume

Genetic and Environmental Effects on Blood Cells

1993 ◽  
Vol 42 (3-4) ◽  
pp. 245-252 ◽  
Author(s):  
G.M.D. Dal Colletto ◽  
D.W. Fulker ◽  
O.C. de O. Barretto ◽  
M. Kolya
Keyword(s):  
Cell Count ◽  
Cell Volume ◽  
White Cell Count ◽  
Haemoglobin Concentration ◽  
Red Cell ◽  
Heritable Variation ◽  
Mean Cell Volume ◽  
Twin Analysis ◽  
Sources Of Variation ◽  
Red Cell Count

AbstractIn a sample of 105 concordant sex MZ and DZ twin pairs, the following characteristics were measured: red cell count, haemoglobin concentration, package cell volume, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, reticulocytes, platelets, white cell count and the six types of leucocytes, lymphocytes, monocytes, band and segmented neutrophils, eosinophils and basophils. The statistical model employed in the univariate twin analysis allows for three sources of variation: genetic (h2), shared environmental (c2) and specific environmental influences (e2). A genetic component was significant for red cell count, haemoglobin and mean cell haemoglobin (0.64, 0.60 and 0.46 respectively), with heritable variation suggested for package cell volume, mean cell volume, mean cell haemoglobin, lymphocytes and monocytes. Shared environmental variation was only present for neutrophils.

scholarly journals Haematological Alterations among Cement Loaders in Port Harcourt, Nigeria

2020 ◽  
pp. 1-8
Author(s):  
Ransom Baribefii Jacob ◽  
Chinyelu Obianuju Mba ◽  
Patience Deborah Iduh
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Study Design ◽  
Haemoglobin Concentration ◽  
Healthy Male Subject ◽  
Cement Dust ◽  
Cross Sectional ◽  
Mean Cell Volume ◽  
Port Harcourt ◽  
Significant Difference

Background: Exposure to cement dust without necessary precautions to prevent its inhalation is found to cause respiratory, dermatological, ocular as well as hematological problems and this is a matter of great concern to the health of cement loaders. Aim of Study: This study was aimed at determining haematological alterations among cement loaders in Port Harcourt, Nigeria. Study Design: Cross sectional study design. Methodology: A total of 100 apparently healthy male subject consisting of 50 cement loaders and 50 non cement loaders aged between the ages of 20- 45years old were recruited for the study. Four millilitres (4 mls) of blood was collected aseptically from the antecubital vein of each participant using standard venepuncture technique into ethylene diamine tetra acetic acid (EDTA) anticoagulated vacutainer bottles with proper mixing to avoid blood clotting and then analysed using Sysmex haematology autoanalyser. Graphpad prism version 6.2 was used to analyse the data obtained. Results: Results obtained showed a statistically higher value (p<0.05) in platelet count (p=0.0001), lower values (p<0.05) in haemoglobin concentration (Hb), Packed cell volume (PCV), Mean cell volume (MCV) and Mean cell haemoglobin (MCH) (p=0.0001). No significant difference (p>0.05) was observed in the mean red blood cell (RBC) count value (p=0.3110), white blood cell (WBC) count (p=0.8138) and mean cell haemoglobin concentration (MCHC) (p=0.0584) respectively. Conclusion and Recommendation: This study has confirmed that there are haematological alterations among cement loaders in Port Harcourt, Nigeria and these alterations are attributed to inhalation of cement dust during work. It is recommended that cement loaders should be mandated to use appropriate personal protective equipment during work hours and around areas where cement dust are generated.

scholarly journals Physiological and bacteriological profile of the fish Clarias gariepinus (Siluriformes: Clariidae) chronically exposed to different concentrations of municipal waste leachate in Nigeria

2019 ◽  
Vol 11 (2) ◽  
pp. 182-197
Author(s):  
Olufemi David Owolabi ◽  
Funmilola Janet Abioye ◽  
Patricia Folakemi Omojasola ◽  
Olufunbi Praise Aina
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Environmental Concern ◽  
Clarias Gariepinus ◽  
Haemoglobin Concentration ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Mean Cell Volume ◽  
Regulatory Limits ◽  
Bacteriological Profile

Introduction: One of the most commonly used methods of waste management is landfilling, which has been a major environmental concern. Objective: To examine the effect of leachate on Clarias gariepinus. Methods: We tested Clarias gariepinus (n=700) with varying concentrations of leachate (0, 10, 15, 20 and 25%) from the Amoyo dumpsite, Ilorin, Nigeria. After 28-day exposure, haematological, biochemical, bacteriological and histopathological assays were carried out. Results: pH ranged from 7,78 to 13,97; cadmium, iron, lead, manganese and zinc were 178-, 134-, 6248-, 400- and 3-fold, respectively, higher than the regulatory limits for waterbodies, while copper fell within the limits. Values of red blood cell, haemoglobin, packed cell volume, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, lymphocytes and monocytes were significantly lower than the control. Conversely, white blood cell, neutrophils and eosinophils increased in a concentration-dependent manner. There were tissue-specific differences in the responses of all biochemical parameters investigated except for protein that significantly decreased in all the tissues. veitisiete bacterial isolates classified into seven genera including Bacillus, Klebsiella, Pseudomonas, Staphylococcus, Acinetobacter, Escherichia and Micrococcus were recorded from the leachate and selected organs of C. gariepinus. The total bacterial, viable coliform and total counts in the leachate were 4,2×106CFU/mL, 3,8×108CFU/mL, 3,6× 106CFU/mL and 2,7×108CFU/mL, respectively. The highest counts were recorded in the gills (14,2×106CFU/mL) and lowest in the muscle (2,7×106CFU/mL) at the highest and least concentration of the leachate, respectively. Most of the bacteria isolated from the leachate were also recovered from the fish organs. Escherichia coli had the highest frequency of occurrence (26%). Conclusion: This study revealed that toxic constituents of the leachate elicited deleterious changes in the bacteriology and physiology of C. gariepinus.

scholarly journals Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency

1996 ◽  
Vol 75 (4) ◽  
pp. 623-636 ◽  
Author(s):  
AnnetJ.C Roodenburg ◽  
Clive E West ◽  
Robert Hovenierl ◽  
Anton C Beynen
Keyword(s):  
Vitamin A ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Binding Capacity ◽  
Vitamin A Deficiency ◽  
Haemoglobin Concentration ◽  
Erythrocyte Count ◽  
Male Rats ◽  
Mean Cell Volume ◽  
Supplemental Vitamin

Studies with anaemic children and pregnant women from areas where vitamin A deficiency is endemic have shown a beneficial effect on Fe status of supplemental vitamin A in addition to Fe supplementation. This suggests a relationship between vitamin Aand Fe status, which we attempted to mimic in rats with anaemia and chronic vitaminA deficiency. Male rats were fed on Fe-adequate diets (35 mg Fe/kg)containing different levels of vitamin A (1200,450,150,75 and 0 retinol equivalents (RE)/kg feed) until they were 5 weeks old. These diets wereidentical to the diets fed to their mothers. Then the young male rats were transferred to diets containing the same levels of vitamin A but no added Fe. After another 2 weeks the rats wererepleted with Fe (35 mg/kg feed) without or with vitamin A to a level of 1200 RE/kg feed. Increased vitamin A intake by the groups previously fed on diets with either 0 or 75 RE/kg produced a reduction in blood haemoglobin concentration, packed cell volume and erythrocyte count. In the group which had been fed on the diet without vitamin A, supplemental vitamin A raised mean cell volume, plasma Fe concentration and total Fe-binding capacity. Vitamin A supplementation during the period of Fe repletion produceda decrease in splenic and tibia Fe concentration, the effect being greater with increasing seventy of previous vitamin A deficiency. The paradoxical effect of supplemental vitamin A on haemoglobin, packed cell volume and erythrocyte count can be explained by a decrease in the degree of haemwoncentration. Thus, the positive effect of supplemental vitamin A seen in humans is also observed with rats under controlled experimental conditions. We speculate that supplemental vitamin A during Fe repletion contributes to optimum erythropoiesis and Fe mobilization when baseline vitamin A status is impaired

Seasonal variations in blood composition in high and low potassium type Marwari sheep

1971 ◽  
Vol 77 (1) ◽  
pp. 37-41 ◽  
Author(s):  
G. C. Taneja ◽  
P. K. Ghosh ◽  
R. K. Abichandani ◽  
D. Goyal
Keyword(s):  
Cell Volume ◽  
Environmental Changes ◽  
Haemoglobin Concentration ◽  
Inorganic Phosphorus ◽  
Specific Conductance ◽  
Blood Cell Count ◽  
Mean Cell Volume ◽  
Individual Variations ◽  
Low Potassium ◽  
Red Blood Cell Count

SummaryBlood samples were obtained at monthly intervals for 12 months from 8 HK and 8 LK wethers of the Marwari breed maintained at Jodhpur (26° 05′ N, 73° 01′ E). The samples were analysed for packed cell volume (PCV), red blood cell count (RBC), haemoglobin concentration (Hb), mean cell volume (MCV), mean cell haemoglobin concentration (MCHC), plasma inorganic phosphorus and plasma specific conductance.The HK animals, on average, had significantly higher PCV, RBC, Hb, MCHC and plasma inorganic phosphorus values than the LK animals but the MCV was significantly higher in the LK group. There was no difference in the plasma specific conductance.PCV, RBC and Hb values differed considerably from animal to animal within each group. These individual variations could help the breed to survive in a desert environment.No particular tendency or pattern in the effect of season on the blood characters studied has been observed. This indicates that the animals of both groups responded in a similar way to the environmental changes.

Effects of equi-protein replacement of soybean meal with graded levels of differently processed rubber seed meal on health status of broiler chickens

2020 ◽  
Vol 47 (1) ◽  
pp. 81-89
Author(s):  
S. K. Akinsanmi ◽  
F. A. Igbasan ◽  
J. O. Agbede ◽  
C. O. Joachim
Keyword(s):  
Health Status ◽  
Cell Volume ◽  
Soybean Meal ◽  
Blood Cells ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Haemoglobin Concentration ◽  
Mean Cell Volume ◽  
Rubber Seed ◽  
Erythrocyte Sedimentation

The nutritional qualities of feed stuff are best examined on the effect of it on the health status of animals, this experiment was conducted to evaluate the effect of incorporation of graded levels of differently processed rubber seed meal (RSM) into broiler chicken diets on the health status of the birds. Two samples of RSM were subjected to different processing methods; soaking in hot water (HWRSM) and roasting (RRSM) and were incorporated into broiler chicken diets to replace soya bean meal at 15, 25 and 35% equi-protein replacement levels in six weeks feeding trial. At maturity of the birds, blood was collected for haematological (packed cell volume; erythrocyte sedimentation rate; Red blood cells; Haemoglobin concentration; mean cell volume; mean cell haemoglobin and mean cell haemoglobin concentration; lymphocytes; neutrophils; monocytes; basophiles and eosinophil) and Serological parameters (total serum protein; aspartic aminotransferase; alkaline aminotransferase; cholesterol; urea; albumin; globulin; albumin / globulin and creatinine). The result showed that there were no significant (P≥0.05) differences in all haematological variables and serological indices measured except cholesterol, as compared with those birds on soybean meal-based diets. The values of cholesterol of birds on the dietary treatments were significantly lower than those in soybean meal-based diet. The average values of all haematological variables; packed cell volume (27.50 - 28.67% ); erythrocyte sedimentation rate(3.00 -3.33%); Red blood cells ( 3.10 - 3.70%); Haemoglobin concentration (9.15 - 9.55%); mean cell volume (81.70- 93.07%); mean cell haemoglobin (27.31-31.01pg) and mean cell haemoglobin concentration (33.16-33.37 g/dL) lymphocytes (30.17-31.33%); neutrophils (22.17- 24.50%); monocytes (10.50 -13.33%); basophiles (2.33 -2.83%); eosinophil (0.67 -1.33%) and serological indices; TSP (3.16 -3.74 mg/dl); aspartic aminotransferase (16.50 - 21.30 µ/d ); alkaline aminotransferase (4.84 -10.40 µ/d), cholesterol (107.64 -146.32 mg/dL); Urea (10.22 - 11.08 mg/dL); Albumin (11.63 - 14.18 g/dL) Globulin (7.47 -17.70 g/dL); Albumin / globulin (0.85 - 2.79) and creatinine (4.98- 6.80 mg/dL) were within the established range for healthy birds. Suggesting that feeding of processed rubber seed meals-based diets have no noticeable adverse effect on health status of broiler chickens and can be included in their meal at these levels.

scholarly journals The effectiveness of various iron-supplementation regimens in improving the Fe status of anaemic rats

1990 ◽  
Vol 63 (3) ◽  
pp. 579-585 ◽  
Author(s):  
A. J. A Wright ◽  
Susan Southon
Keyword(s):  
Single Dose ◽  
Cell Volume ◽  
Iron Supplementation ◽  
Human Subjects ◽  
Haemoglobin Concentration ◽  
Suppressive Effect ◽  
Evening Meal ◽  
Short Term ◽  
Mean Cell Volume ◽  
The Cost

Less frequent iron supplementation may be equally as beneficial to Fe-deficient subjects as routine daily supplementation because of the short-term suppressive effect of oral dosing with large amounts of Fe on subsequent Fe absorption. In the present study, the possibility that the administration of an Fe supplement every 2nd or 3rd day may be as effective in improving Fe status as a daily supplement was investigated in anaemic rats. Anaemic rats were given a 4 mg Fe supplement every day, on alternate days or every 3rd day, as a single dose with a midday meal or as a multiple dose with a morning, midday and evening meal. A low-Fe diet (13 mg/kg) was given at all other times. After 7 d, erythrocyte count, packed cell volume, mean cell volume, haemoglobin concentration and total liver Fe were measured and compared with those of meal-fed rats which had not been given any supplemental Fe. Rats which received a supplement every 3rd day, a total supplement of 12 mg, had a similar Fe status to those receiving a daily supplement, a total supplement of 28 mg. Administration of the supplement as a multiple, rather than as a single dose did not improve recovery from the Fe deficiency. It is suggested that less frequent supplementation with a smaller total amount of Fe, should be considered in human subjects. Such a regimen would minimize unpleasant side-effects of oral Fe therapy, decrease the risk of adverse effects of Fe on the absorption of other essential minerals and substantially cut the cost of supplementation programmes.

scholarly journals The determinants of iron status in early pregnancy

1998 ◽  
Vol 79 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Siân Robinson ◽  
Keith Godfrey ◽  
Jonathan Denne ◽  
Vanessa Cox
Keyword(s):  
Cell Volume ◽  
Serum Ferritin ◽  
Early Pregnancy ◽  
Iron Status ◽  
Population Sample ◽  
Haemoglobin Concentration ◽  
Mean Cell Volume ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration ◽  
Multiparous Women

In pregnancy, the additional demands for Fe are thought to be met principally through increased maternal dietary Fe absorption and by mobilization of maternal Fe stores. In a general population sample of 576 women we examined the maternal and dietary characteristics which influenced Fe stores (assessed by serum ferritin concentration) in early pregnancy. The effects of these characteristics on two measures of functional Fe status (mean cell volume and haemoglobin concentration) were also considered. Serum ferritin concentrations were lower in multiparous women (P < 0.0001) and in those with a lower BMI (P = 0.01), and rose with increasing alcohol intake (P < 0.0001). Ferritin concentrations fell with increasing Ca intake (P < 0.0001); the proportion of women with serum ferritin values ≤ 12 μg/l rose from 14% of the women in the lowest quarter of Ca intake to 29% of the women in the highest quarter. Mean cell volume and haemoglobin concentration were not related to Ca intake in early pregnancy. Although Ca added to test-meals reduces Fe absorption, long-term Ca supplementation has not been shown to lower plasma ferritin concentration, suggesting that high habitual Ca intakes would be unlikely to influence Fe status in non-pregnant individuals. Our findings show that in early pregnancy there is an association between high dietary Ca intake and lower Fe stores. This effect of Ca on one aspect of Fe status may result from its influence on Fe bioavailability.

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