Motor impairment in very preterm-born children: links with other developmental deficits at 5 years of age

2013 ◽  
Vol 56 (6) ◽  
pp. 587-594 ◽  
Author(s):  
Janeline W Van Hus ◽  
Eva S Potharst ◽  
Martine Jeukens-Visser ◽  
Joke H Kok ◽  
Aleid G Van Wassenaer-Leemhuis
2019 ◽  
Vol 129 ◽  
pp. 45-51 ◽  
Author(s):  
Regula Everts ◽  
Corina G. Schöne ◽  
Ines Mürner-Lavanchy ◽  
Maja Steinlin

2017 ◽  
Vol 38 (11) ◽  
pp. 5577-5589 ◽  
Author(s):  
Sarah I. Mossad ◽  
Mary Lou Smith ◽  
Elizabeth W. Pang ◽  
Margot J. Taylor

2011 ◽  
Vol 53 (11) ◽  
pp. 1000-1006 ◽  
Author(s):  
ALICIA J SPITTLE ◽  
JEANIE CHEONG ◽  
LEX W DOYLE ◽  
GEHAN ROBERTS ◽  
KATHERINE J LEE ◽  
...  

2012 ◽  
Vol 72 (6) ◽  
pp. 641-648 ◽  
Author(s):  
Jozien C. Tanis ◽  
Meike H. van der Ree ◽  
Elise Roze ◽  
Anna E. Huis in ‘t Veld ◽  
Paul P. van den Berg ◽  
...  

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A30-A30
Author(s):  
N. G. Casares ◽  
S. F. Walsh ◽  
M. Allin ◽  
M. Walshe ◽  
R. Murray ◽  
...  

2021 ◽  
Vol 9 ◽  
Author(s):  
Pauline E. van Beek ◽  
Iris E. van der Horst ◽  
Josse Wetzer ◽  
Anneloes L. van Baar ◽  
Brigitte Vugs ◽  
...  

Aim: Long-term outcome data in preterm children is often limited to cross-sectional measurement of neurodevelopmental impairment (NDI) at the corrected age of 24-36 months. However, impairments may only become overt during childhood or resolve with time, and individual trajectories in outcome over time may vary. The primary aim of this study was to describe NDI in very preterm born children at three subsequent ages of 2, 5, and 8 years of age. As a secondary aim, a longitudinal analysis was performed on the individual longitudinal trajectories in NDI from 2 to 8 years of age.Methods: Single-center prospective cohort study including children born between 1990 and 2011 below 30 weeks' gestation and followed into 2019. The outcome measurement was NDI assessed at 2, 5, and 8 years of age. NDI is a composite score that includes cognitive, neurological, visual, and auditory functions, in which problems were categorized as none, mild, moderate, or severe. Cognitive function measured as total DQ/IQ score was assessed by standardized psychometric tests. Neurological, visual, and auditory functions were assessed by the neonatologist.Results: In total, 921 children were eligible for follow-up, of whom 726 (79%) children were assessed. No NDI was seen in 54, 54, and 62%, mild NDI was seen in 31, 36, and 30%, and moderate-to-severe NDI was seen in 15, 9.2, and 8.6% of the children at 2, 5, and 8 years, respectively. From 2 to 8 years, 63% of the children remained in the same NDI category, 20% of the children improved to a better NDI category, and 17% deteriorated toward a worse NDI category. No differences were found in baseline characteristics of infants that improved or deteriorated. Extreme prematurity, male gender and low parental education were associated with worse NDI status at all time points. Although we observed considerable individual variation over time in NDI status, the course of the trajectories in NDI were not associated with gestation, gender, and parental education.Conclusions: Continued follow-up until school life is essential in order to provide optimal and individually focused referrals and care when needed.


2014 ◽  
Vol 39 (7) ◽  
pp. 529-542 ◽  
Author(s):  
Ines Mürner-Lavanchy ◽  
Maja Steinlin ◽  
Claus Kiefer ◽  
Christian Weisstanner ◽  
Barbara Catherine Ritter ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Preethi Mathew ◽  
Kerstin Pannek ◽  
Pamela Snow ◽  
M. Giulia D'Acunto ◽  
Andrea Guzzetta ◽  
...  

Background. The etiology of motor impairments in preterm infants is multifactorial and incompletely understood. Whether corpus callosum development is related to impaired motor function is unclear. Potential associations between motor-related measures and diffusion tensor imaging (DTI) of the corpus callosum in preterm infants were explored.Methods. Eight very preterm infants (gestational age of 28–32 weeks) underwent the Hammersmith neonatal neurological examination and DTI assessments at gestational age of 42 weeks. The total Hammersmith score and a motor-specific score (sum of Hammersmith motor subcategories) were calculated. Six corpus callosum regions of interest were defined on the mid-sagittal DTI slice—genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium. The fractional anisotropy (FA) and mean diffusivity (MD) of these regions were computed, and correlations between these and Hammersmith measures were sought.Results. Anterior midbody FA measures correlated positively with total Hammersmith (rho=0.929,P=0.001) and motor-specific scores (rho=0.857,P=0.007). Total Hammersmith scores also negatively correlated with anterior midbody MD measures (rho=−0.714,P=0.047).Discussion. These results suggest the integrity of corpus callosum axons, particularly anterior midbody axons, is important in mediating neurological functions. Greater callosal maturation was associated with greater motor function. Corpus callosum DTI may prove to be a valuable screening or prognostic marker.


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