Heterogeneity of chromatoid bodies in adult pluripotent stem cells of planarianDugesia japonica

2016 ◽  
Vol 58 (2) ◽  
pp. 225-237 ◽  
Author(s):  
Makoto Kashima ◽  
Nobuyoshi Kumagai ◽  
Kiyokazu Agata ◽  
Norito Shibata
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Chromatoid Bodies ◽  
Adult Pluripotent Stem Cells

Differentiation of nerve-derived adult pluripotent stem cells into osteoblastic and endothelial cells

2017 ◽  
Vol 17 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Shang-You Yang ◽  
Nora Strong ◽  
Xuan Gong ◽  
Michael H. Heggeness
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Pluripotent Stem Cells ◽  
Adult Pluripotent Stem Cells

Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease

2009 ◽  
Vol 255 (1-2) ◽  
pp. 55-60 ◽  
Author(s):  
Magdalena Kovacsovics-Bankowski ◽  
Philip R. Streeter ◽  
Kelsey A. Mauch ◽  
Mark R. Frey ◽  
Amy Raber ◽  
...  
Keyword(s):  
Stem Cells ◽  
Graft Versus Host Disease ◽  
Pluripotent Stem Cells ◽  
Clinical Scale ◽  
Host Disease ◽  
Graft Versus Host ◽  
Adult Pluripotent Stem Cells

scholarly journals Prospectively Isolated Tetraspanin+ Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

Cell ◽  
2018 ◽  
Vol 173 (7) ◽  
pp. 1593-1608.e20 ◽  
Author(s):  
An Zeng ◽  
Hua Li ◽  
Longhua Guo ◽  
Xin Gao ◽  
Sean McKinney ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Adult Pluripotent Stem Cells

scholarly journals Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Carolyn E Adler ◽  
Chris W Seidel ◽  
Sean A McKinney ◽  
Alejandro Sánchez Alvarado
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Sodium Azide ◽  
Pluripotent Stem Cells ◽  
Forkhead Transcription Factor ◽  
Organ Regeneration ◽  
Wide Range ◽  
Organ Specific ◽  
Adult Pluripotent Stem Cells ◽  
Single Organ

Planarian flatworms regenerate every organ after amputation. Adult pluripotent stem cells drive this ability, but how injury activates and directs stem cells into the appropriate lineages is unclear. Here we describe a single-organ regeneration assay in which ejection of the planarian pharynx is selectively induced by brief exposure of animals to sodium azide. To identify genes required for pharynx regeneration, we performed an RNAi screen of 356 genes upregulated after amputation, using successful feeding as a proxy for regeneration. We found that knockdown of 20 genes caused a wide range of regeneration phenotypes and that RNAi of the forkhead transcription factor FoxA, which is expressed in a subpopulation of stem cells, specifically inhibited regrowth of the pharynx. Selective amputation of the pharynx therefore permits the identification of genes required for organ-specific regeneration and suggests an ancient function for FoxA-dependent transcriptional programs in driving regeneration.

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent
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