scholarly journals Early development of circadian rhythmicity in the suprachiamatic nuclei and pineal gland of teleost, flounder (Paralichthys olivaeus), embryos

2015 ◽  
Vol 57 (6) ◽  
pp. 444-452 ◽  
Author(s):  
Makoto Mogi ◽  
Susumu Uji ◽  
Hayato Yokoi ◽  
Tohru Suzuki
Keyword(s):  
Pineal Gland ◽  
Early Development ◽  
Circadian Rhythmicity

Circadian rhythmicity in the methylation of 5-hydroxy-indoles and norepinephrine in the pineal gland of 10 day old rats

1978 ◽  
Vol 43 (2) ◽  
pp. 167-175 ◽  
Author(s):  
M. G. M. Balemans ◽  
F. A. M. Bary ◽  
W. C. Legerstee ◽  
E. M. Noordegraaf
Keyword(s):  
Pineal Gland ◽  
Circadian Rhythmicity ◽  
Old Rats

scholarly journals The influence of some pterins on the circadian rhythmicity of hydroxyindole-O-methyl transferase in the pineal gland of 42-day old male Wistar rats

1980 ◽  
Vol 20 (4A) ◽  
pp. 1051-1060 ◽  
Author(s):  
M. G. M. BALEMANS ◽  
J. Van BENTHEM ◽  
W. C. LEGERSTEE ◽  
A. de MOREE ◽  
H. J. P. M. NOTEBORN ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Wistar Rats ◽  
Circadian Rhythmicity ◽  
Methyl Transferase ◽  
Male Wistar Rats

scholarly journals Hundreds of LncRNAs Display Circadian Rhythmicity in Zebrafish Larvae

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3173
Author(s):  
Shital Kumar Mishra ◽  
Zhaomin Zhong ◽  
Han Wang
Keyword(s):  
Pineal Gland ◽  
3D Structure ◽  
Data Bank ◽  
Circadian Rhythmicity ◽  
Constant Darkness ◽  
Rna Seq ◽  
Functional Studies ◽  
Zebrafish Larvae ◽  
Sequencing Technologies ◽  
Computational Analyses

Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in various life processes, including circadian rhythms. Although next generation sequencing technologies have facilitated faster profiling of lncRNAs, the resulting datasets require sophisticated computational analyses. In particular, the regulatory roles of lncRNAs in circadian clocks are far from being completely understood. In this study, we conducted RNA-seq-based transcriptome analysis of zebrafish larvae under both constant darkness (DD) and constant light (LL) conditions in a circadian manner, employing state-of-the-art computational approaches to identify approximately 3220 lncRNAs from zebrafish larvae, and then uncovered 269 and 309 lncRNAs displaying circadian rhythmicity under DD and LL conditions, respectively, with 30 of them are coexpressed under both DD and LL conditions. Subsequently, GO, COG, and KEGG pathway enrichment analyses of all these circadianly expressed lncRNAs suggested their potential involvement in numerous biological processes. Comparison of these circadianly expressed zebrafish larval lncRNAs, with rhythmically expressed lncRNAs in the zebrafish pineal gland and zebrafish testis, revealed that nine (DD) and twelve (LL) larval lncRNAs are coexpressed in the zebrafish pineal gland and testis, respectively. Intriguingly, among peptides encoded by these coexpressing circadianly expressed lncRNAs, three peptides (DD) and one peptide (LL) were found to have the known domains from the Protein Data Bank. Further, the conservation analysis of these circadianly expressed zebrafish larval lncRNAs with human and mouse genomes uncovered one lncRNA and four lncRNAs shared by all three species under DD and LL conditions, respectively. We also investigated the conserved lncRNA-encoded peptides and found one peptide under DD condition conserved in these three species and computationally predicted its 3D structure and functions. Our study reveals that hundreds of lncRNAs from zebrafish larvae exhibit circadian rhythmicity and should help set the stage for their further functional studies.

Individual differences, social attention, and the history of the social motivation hypotheses of autism

2019 ◽  
Vol 42 ◽  
Author(s):  
Peter C. Mundy
Keyword(s):  
Individual Differences ◽  
Early Development ◽  
Emotional Development ◽  
Social Motivation ◽  
Social Attention ◽  
Social Emotional Development ◽  
Social Emotional ◽  
Precise Understanding ◽  
The Social ◽  
History Of

Abstract The stereotype of people with autism as unresponsive or uninterested in other people was prominent in the 1980s. However, this view of autism has steadily given way to recognition of important individual differences in the social-emotional development of affected people and a more precise understanding of the possible role social motivation has in their early development.

Classical social reward signatures in infants with later ASD

2019 ◽  
Vol 42 ◽  
Author(s):  
Teodora Gliga ◽  
Mayada Elsabbagh
Keyword(s):  
Early Development ◽  
Social Motivation ◽  
Self Report ◽  
Social Reward ◽  
Socially Motivated

Abstract Autistic individuals can be socially motivated. We disagree with the idea that self-report is sufficient to understand their social drive. Instead, we underscore evidence for typical non-verbal signatures of social reward during the early development of autistic individuals. Instead of focusing on whether or not social motivation is typical, research should investigate the factors that modulate social drives.

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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