Long‐term outcomes of endoscopic balloon dilation for intestinal strictures in patients with Crohn’s disease during maintenance treatment with anti‐tumor necrosis factor alpha antibodies

2021 ◽  
Author(s):  
Teruyuki Takeda ◽  
Masahiro Kishi ◽  
Noritaka Takatsu ◽  
Yasumichi Takada ◽  
Tsuyoshi Beppu ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Maintenance Treatment ◽  
Balloon Dilation ◽  
Endoscopic Balloon Dilation ◽  
Long Term Outcomes ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Endoscopic Balloon

scholarly journals Induced myelopathy after long-term anti-tumor necrosis factor alpha treatment

2011 ◽  
Vol 9 (S1) ◽  
Author(s):  
C Modesto ◽  
F Caracsegui ◽  
S Melendo ◽  
A Sanchez-Montanez ◽  
Manel Roig
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Exposure to prolonged unpredictable light impairs spatial memory via induction of oxidative stress and tumor necrosis factor-alpha in rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Oluwaseun S. Faborode ◽  
Issa O. Yusuf ◽  
Paschal O. Okpe ◽  
Ann O. Okudaje ◽  
Samuel A. Onasanwo
Keyword(s):  
Oxidative Stress ◽  
Object Recognition ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Light Exposure ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Objectives The human body physiology rapidly changes and adapt to several environmental stimuli, including light. Abnormal artificial light exposures have been shown to affect sleep cycle, cognition, and mood. Although studies have reported inconsistent effects of short-term or constant long-term light exposures, human exposures to artificial lights occur at varying, unpredictable times and duration daily. Here, we studied the effects of long-term unpredictable light exposure on learning, memory, oxidative status, and associated cytokines in rats. Methods Artificial lighting was provided using an array of white light-emitting diodes coupled to a microcontroller that switches them on or off at unpredictable times and duration (light intensity = 200 ± 20 lx). Within the last eight days of 40 days exposure, animals were subjected to open field test, Morris water maze, and novel object recognition behavioral paradigms. Brain levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione S-transferase (GST), tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF) were assayed. Results Exposed rats showed impaired spatial learning and memory (p<0.05), but no changes in object recognition memory or locomotor activity. Oxidative stress analyses also revealed significant changes in the concentrations of MDA, SOD, catalase, and GSH levels (p<0.05), not GST. Similarly, there was an increased TNF-α expression (p<0.05), not VEGF. Conclusions We conclude that oxidative stress is involved in memory impairment in rats exposed to prolonged unpredictable lights, which again suggests the detrimental effects of extended light exposure on the nervous system.

scholarly journals Long-Term Outcomes of Endoscopic Balloon Dilation for Benign Strictures in Patients with Inflammatory Bowel Disease

Gut and Liver ◽  
2018 ◽  
Vol 12 (5) ◽  
pp. 530-536 ◽  
Author(s):  
Hye Won Lee ◽  
Soo Jung Park ◽  
Seong Ran Jeon ◽  
Byong Duk Ye ◽  
Jae Jun Park ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Balloon Dilation ◽  
Endoscopic Balloon Dilation ◽  
Long Term Outcomes ◽  
Inflammatory Bowel ◽  
Endoscopic Balloon
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