Efficacy of carbon dioxide versus air insufflation according to different sedation protocols during therapeutic endoscopic retrograde cholangiopancreatography: P rospective, randomized, double‐blind study

2015 ◽  
Vol 27 (4) ◽  
pp. 512-521 ◽  
Author(s):  
Su Jin Lee ◽  
Tae Hoon Lee ◽  
Sang‐Heum Park ◽  
Yun Nah Lee ◽  
Yunho Jung ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Blind Study ◽  
Double Blind Study ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Air Insufflation

scholarly journals Doxapram as an additive to propofol sedation for endoscopic retrograde cholangiopancreatography: a placebo-controlled, randomized, double-blinded study

2020 ◽  
Vol 34 (12) ◽  
pp. 5477-5483 ◽  
Author(s):  
Jarno Jokelainen ◽  
Anna Belozerskikh ◽  
Harri Mustonen ◽  
Marianne Udd ◽  
Leena Kylänpää ◽  
...  
Keyword(s):  
Respiratory Depression ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Significant Rise ◽  
Repeated Measurements ◽  
Double Blind Study ◽  
Continuous Variables ◽  
Endoscopic Retrograde ◽  
Double Blind ◽  
Clinical Trial Registration ◽  
Propofol Sedation

Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) requires moderate to deep sedation, usually with propofol. Adverse effects of propofol sedation are relatively common, such as respiratory and cardiovascular depression. This study was conducted to determine if doxapram, a respiratory stimulant, could be used to reduce the incidence of respiratory depression. Methods This is a single-center, prospective randomized double-blind study performed in the endoscopy unit of Helsinki University Central Hospital. 56 patients were randomized in a 1:1 ratio to either receive doxapram as an initial 1 mg/kg bolus and an infusion of 1 mg/kg/h (group DOX) or placebo (group P) during propofol sedation for ERCP. Main outcome measures were apneic episodes and hypoxemia (SpO2 < 90%). Mann–Whitney test for continuous variables and Fisher’s exact test for discrete variables were used and mixed effects modeling to take into account repeated measurements on the same subject and comparing both changes within a group as a function of time and between the groups. Results There were no statistically significant differences in apneic episodes (p = 0.18) or hypoxemia (p = 0.53) between the groups. There was a statistically significant rise in etCO2 levels in both groups, but the rise was smaller in group P. There was a statistically significant rise in Bispectral Index (p = 0.002) but not modified Observer’s Assessment of Agitation/Sedation (p = 0.21) in group P. There were no statistically significant differences in any other measured parameters. Conclusions Doxapram was not effective in reducing respiratory depression caused by deep propofol sedation during ERCP. Further studies are warranted using different sedation protocols and dosing regimens. Clinical trial registration ClinicalTrials.gov ID NCT02171910.

scholarly journals Comparison of carbon dioxide and air insufflation use by non-expert endoscopists during endoscopic retrograde cholangiopancreatography

2012 ◽  
Vol 25 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Takashi Muraki ◽  
Norikazu Arakura ◽  
Ryou Kodama ◽  
Suguru Yoneda ◽  
Masafumi Maruyama ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Endoscopic Retrograde ◽  
Air Insufflation
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