Diagnostic utility of high‐risk human papillomavirus mRNA in situ hybridisation in squamous cell carcinoma of unknown primary in the head and neck and implementing American Society of Clinical Oncology guideline recommendations

Cytopathology ◽  
2020 ◽  
Vol 31 (6) ◽  
pp. 547-554
Author(s):  
Parnaz Daneshpajouhnejad ◽  
James Adam Miller ◽  
Zahra Maleki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
High Risk ◽  
In Situ Hybridisation ◽  
Unknown Primary ◽  
Diagnostic Utility ◽  
Carcinoma Of Unknown Primary ◽  
American Society ◽  
Mrna In Situ Hybridisation

Absence of disruptive TP53 mutations in high‐risk human papillomavirus‐driven neck squamous cell carcinoma of unknown primary

Head & Neck ◽  
2019 ◽  
Vol 41 (11) ◽  
pp. 3833-3841
Author(s):  
Paolo Boscolo‐Rizzo ◽  
Lea Schroeder ◽  
Valeria Sacchetto ◽  
Dana Holzinger ◽  
Maria Cristina Da Mosto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Tp53 Mutations

scholarly journals Human Papillomavirus and Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region: A Comprehensive Review on Clinical Implications

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1297
Author(s):  
Mikkel Hjordt Holm Larsen ◽  
Hani Ibrahim Channir ◽  
Christian von Buchwald
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Unknown Primary ◽  
Diagnostic Strategy ◽  
Primary Tumor Site ◽  
Carcinoma Of Unknown Primary ◽  
Diagnostic Modalities

Squamous cell carcinoma of unknown primary (SCCUP) is a challenging diagnostic subgroup of oropharyngeal squamous cell carcinoma (OPSCC). The incidence of SCCUP is increasing in parallel with the well-documented increase in OPSCC and is likewise driven by the increase in human papillomavirus (HPV). The SCCUP patient often presents with a cystic lymph node metastasis and undergoes an aggressive diagnostic and treatment program. Detection of HPV in cytologic specimens indicates an oropharyngeal primary tumor origin and can guide the further diagnostic strategy. Advances in diagnostic modalities, e.g., transoral robotic surgery and transoral laser microsurgery, have increased the successful identification of the primary tumor site in HPV-induced SCCUP, and this harbors a potential for de-escalation treatment and increased survival. This review provides an overview of HPV-induced SCCUP, diagnostic modalities, and treatment options.

scholarly journals Unilateral radiotherapy treatment for p16/human papillomavirus-positive squamous cell carcinoma of unknown primary in the head and neck

2018 ◽  
Vol 128 (9) ◽  
pp. 2076-2083 ◽  
Author(s):  
Albert Tiong ◽  
Danny Rischin ◽  
Richard J. Young ◽  
Alan Herschtal ◽  
Ben Solomon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Radiotherapy Treatment
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