Absence of disruptive TP53 mutations in high‐risk human papillomavirus‐driven neck squamous cell carcinoma of unknown primary

Head & Neck ◽  
2019 ◽  
Vol 41 (11) ◽  
pp. 3833-3841
Author(s):  
Paolo Boscolo‐Rizzo ◽  
Lea Schroeder ◽  
Valeria Sacchetto ◽  
Dana Holzinger ◽  
Maria Cristina Da Mosto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Tp53 Mutations

scholarly journals Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy

Head & Neck ◽  
2013 ◽  
Vol 36 (11) ◽  
pp. 1589-1595 ◽  
Author(s):  
Candan Demiroz ◽  
Jeffrey M. Vainshtein ◽  
Georgios V. Koukourakis ◽  
Orit Gutfeld ◽  
Mark E. Prince ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Definitive Radiotherapy

Human Papillomavirus in Metastatic Lymph Nodes from Unknown Primary Head and Neck Squamous Cell Carcinoma

2011 ◽  
Vol 145 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Andrew M. Compton ◽  
Tara Moore-Medlin ◽  
Lilantha Herman-Ferdinandez ◽  
Cheryl Clark ◽  
Gloria C. Caldito ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Unknown Primary ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals Human Papillomavirus and Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region: A Comprehensive Review on Clinical Implications

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1297
Author(s):  
Mikkel Hjordt Holm Larsen ◽  
Hani Ibrahim Channir ◽  
Christian von Buchwald
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Unknown Primary ◽  
Diagnostic Strategy ◽  
Primary Tumor Site ◽  
Carcinoma Of Unknown Primary ◽  
Diagnostic Modalities

Squamous cell carcinoma of unknown primary (SCCUP) is a challenging diagnostic subgroup of oropharyngeal squamous cell carcinoma (OPSCC). The incidence of SCCUP is increasing in parallel with the well-documented increase in OPSCC and is likewise driven by the increase in human papillomavirus (HPV). The SCCUP patient often presents with a cystic lymph node metastasis and undergoes an aggressive diagnostic and treatment program. Detection of HPV in cytologic specimens indicates an oropharyngeal primary tumor origin and can guide the further diagnostic strategy. Advances in diagnostic modalities, e.g., transoral robotic surgery and transoral laser microsurgery, have increased the successful identification of the primary tumor site in HPV-induced SCCUP, and this harbors a potential for de-escalation treatment and increased survival. This review provides an overview of HPV-induced SCCUP, diagnostic modalities, and treatment options.

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