Raspberry bodies and hyaline globules with positive napsin A immunoexpression are useful features in diagnosing clear cell carcinoma of the female genital tract in cytology samples

Cytopathology ◽  
2018 ◽  
Vol 29 (6) ◽  
pp. 600-602 ◽  
Author(s):  
Bharat Rekhi ◽  
Kedar Deodhar ◽  
Seema Gulia ◽  
Jyoti Bajpai
Keyword(s):  
Cell Carcinoma ◽  
Genital Tract ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Napsin A ◽  
Hyaline Globules ◽  
Female Genital

Cytologic Features of Clear Cell Carcinoma of the Female Genital Tract

2004 ◽  
Vol 48 (1) ◽  
pp. 47-51 ◽  
Author(s):  
José A. Jiménez-Heffernan ◽  
Blanca Vicandi ◽  
Pilar González-Peramato ◽  
Ana Pérez-Campos ◽  
Pilar López-Ferrer ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Genital Tract ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Female Genital

Cytology of Clear Cell Carcinoma of the Female Genital Tract in Fine Needle Aspirates and Ascites

2000 ◽  
Vol 44 (6) ◽  
pp. 1005-1009 ◽  
Author(s):  
Şafak Atahan ◽  
Cemil Ekinci ◽  
Fikri İçli ◽  
Nural Erdoğan
Keyword(s):  
Cell Carcinoma ◽  
Genital Tract ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Female Genital

Clear Cell Adenocarcinoma of the Female Genital Tract: Long-Term Outcome and Fertility Aspects After Brachytherapy Aimed at a Conservative Treatment

2012 ◽  
Vol 22 (8) ◽  
pp. 1378-1382 ◽  
Author(s):  
Nicolas Magné ◽  
Cyrus Chargari ◽  
Antonin Levy ◽  
Carlos Rodriguez ◽  
Véronique De Vos ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Pregnancy Rate ◽  
Genital Tract ◽  
Clear Cell ◽  
Female Genital Tract ◽  
Disease Free Survival ◽  
Good Survival ◽  
Clear Cell Adenocarcinoma ◽  
Long Term Outcome ◽  
Female Genital

ObjectivesTo assess the outcome and the fertility aspects in the particular population of cervical and/or vaginal clear cell adenocarcinoma (CCA) associated or not to previous in utero diethylstilbestrol exposure.MethodsFrom January 1970 to December 2003, data from 61 consecutive patients with cervical and/or vaginal histologically proven CCA treated with brachytherapy (BT) aimed at a conservative treatment at the Institut Gustave Roussy as a part of treatment were retrospectively analyzed.ResultsThe median follow-up was 9.4 years, ranging from 0.3 to 27.4 years. The 5-year specific overall survival rate was 79%. The median time of disease-free survival was 5.8 years. In the subgroup of 42 patients with a cervical CCA, 12 patients tried to be pregnant, 2 patients became pregnant and had miscarriages (P2M2 and P1M1). No pregnancy has been observed in 10 patients exclusively owing to anomalies of the reproductive tract: 6 patients had partial or total diaphragm, 2 patients had an anatomical alteration of the uterus, 1 patient had atrophic endometrium, and 1 patient had primary infertility. In the subgroup of 19 patients with a vaginal CCA, 7 patients tried to be pregnant. All of them had no morphological and/or functional anomalies of the genital tract. Three of 7 patients had delivered healthy babies (P1D1, P2D2, and P3M2D1), and another one had a miscarriage (P1M1). Moreover, all babies were delivered by cesarean section. The pregnancy rate was 10% (6 of 61 patients) with 3 healthy babies.ConclusionConservative approach in patients with female genital tract CCA including BT gives good results with good survival rates and an interesting global pregnancy rate.

scholarly journals A Rare Case of Clear Cell Carcinoma, Müllerian Type in the Renal Pelvis of a 21-Year-Old Woman

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Diandra Perez ◽  
Rana Naous
Keyword(s):  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Neoplastic Cells ◽  
Primary Location ◽  
Foamy Macrophages ◽  
Vacuolated Cytoplasm

Clear Cell Carcinomas of Müllerian origin are extremely rare within the upper urinary system. Their morphology is identical to that of the Clear Cell Carcinomas of the female genital tract. When they arise in the urinary tract, it is thought to be due to ectopic Müllerian embryogenesis. Here, we present a case of a 21-year-old woman with a Clear Cell Carcinoma, Müllerian type, arising from the renal pelvis. Histologically, it consisted of tubulopapillary architecture with associated foamy macrophages and a mucinous background. The neoplastic cells exhibited variably sized round nuclei with prominent nucleoli, eosinophilic to vacuolated cytoplasm with occasional intracytoplasmic mucin vacuoles, and a hobnail appearance. Immunohistochemical stains showed that the neoplastic cells were positive for Pax-8, p53, CK7, HMWK 903, and INI-1 and focally positive for p504s (AMACR). The neoplastic cells were negative for GATA-3, CK5/CK6, p63, CK20, and CDX-2 immunostains, ruling out urothelial or enteric phenotype. Additional immunostains performed by an outside institution showed that the neoplastic cells were positive for HNF-1β. The overall morphology and immunophenotype were consistent with Clear Cell Carcinoma of Müllerian origin arising from the renal pelvis. Follow-up revealed no metastasis or other tumor sites, supporting that this was the primary location.

Synchronous primary endometrial and ovarian cancer with three different histologic patterns: A case report

2003 ◽  
Vol 13 (5) ◽  
pp. 678-682 ◽  
Author(s):  
Y.-S. Ree ◽  
S.-H. Cho ◽  
S.-R. Kim ◽  
S.-H. Cho ◽  
K.-T. Kim ◽  
...  
Keyword(s):  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Figo Stage ◽  
Primary Cancer ◽  
Metastatic Lesions ◽  
Synchronous Cancers ◽  
Stage Ia ◽  
The Right ◽  
Female Genital

Synchronous cancers involving both endometrium and ovary in the female genital tract is a well-recognized phenomenon. However, most of them are metastatic lesions arising from one organ and simultaneous primary cancer occurring in both organs is relatively rare. We report a case with dual primary cancer occurring in both ovaries and endometrium with three different histologies. Recently, a 46-year-old women presented with vaginal bleeding was found to have FIGO stage IC clear cell carcinoma of the left ovary, stage IA borderline mucinous cystadoma of the right ovary, and stage IB endometrial carcinoma of endometrioid type. We present this case with a brief review of references.

scholarly journals PD-L1/PD-1 Expression in Endometrial Clear Cell Carcinoma: A Potential Surrogate Marker for Clinical Trials

2019 ◽  
Vol 28 (1) ◽  
pp. 31-37
Author(s):  
Cao Jin ◽  
Sean Hacking ◽  
Sharon Liang ◽  
Mansoor Nasim
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Surrogate Marker ◽  
Myometrial Invasion ◽  
Lymphocyte Infiltration ◽  
Pathological Features ◽  
Napsin A ◽  
Programmed Death ◽  
Clinical And Pathological Features

Background. Endometrial clear cell carcinoma (ECCC) represents a rare subtype of endometrial cancer. Recently, immunotherapeutic drugs targeting programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) was associated with improved survival in several types of cancer (especially in patients with mismatch-repair (MMR)-deficient status). The aim of this study is to evaluate the correlation between the PD-L1/PD-1 axis and clinical and pathological features in strictly defined ECCC diagnosed at our institution. Design. Review of ECCC (diagnosed in the period of 2000 to 2017) identified 23 cases (n = 23) in our institution. The cases were reviewed by 2 gynecological pathologists. Estrogen receptor, progesterone receptor, napsin A, p16, and p53 were also performed so that only pure CCC cases were included. PD-L1 (SP142), PD-1, and MMR antibodies were performed. PD-L1 and PD-1 were scored in both the tumor and the peritumoral lymphocyte infiltration. Clinical and pathological features were recorded to correlate with the expression of the 2 markers. Results. Among the 23 cases, 20 cases were qualified for pure CCC by histology and immunohistochemistry patterns. Regarding PD-1 expression, 6/20 (30%) patients had positive expression in peritumoral lymphocyte infiltration. While 3/20 (15%) cases had PD-L1 either tumoral or peritumoral lymphocytes expression. Loss of MMR expression was present in 1 (5%) of 20 patients. PD-1 and/or PD-L1 expression cases tended to have deeper myometrial invasion and higher stage at presentation. Conclusions. Our results are suggestive of the roles of both PD-1 and PD-L1 in ECCCs as useful therapeutic biomarkers for immunotherapy.

Renal Clear Cell Carcinoma Appearing as a Left Neck Mass

1996 ◽  
Vol 75 (9) ◽  
pp. 620-622 ◽  
Author(s):  
Michael A. Boggess ◽  
T. Oma Hester ◽  
Sanford M. Archer
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Soft Tissues ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Neck Mass ◽  
Renal Clear Cell Carcinoma ◽  
Primary Tumors ◽  
Left Neck

Malignant clear cell tumors of the head and neck are uncommon. Primary tumors may arise from the salivary glands, thyroid gland, or parathyroid glands, while metastatic tumors most commonly arise from the lungs, kidneys, and female genital tract. Renal cell carcinoma is the third most common metastatic tumor to the bone and soft tissues of the head and neck. Despite this, there have been few reported cases of renal clear cell carcinoma metastases to the neck. Here we report a unique case of an otherwise asymptomatic young woman with a left neck mass as the first clinical sign of advanced renal clear cell carcinoma.

Sign in / Sign up

Export Citation Format

Share Document