scholarly journals A Rare Case of Clear Cell Carcinoma, Müllerian Type in the Renal Pelvis of a 21-Year-Old Woman

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Diandra Perez ◽  
Rana Naous
Keyword(s):  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Neoplastic Cells ◽  
Primary Location ◽  
Foamy Macrophages ◽  
Vacuolated Cytoplasm

Clear Cell Carcinomas of Müllerian origin are extremely rare within the upper urinary system. Their morphology is identical to that of the Clear Cell Carcinomas of the female genital tract. When they arise in the urinary tract, it is thought to be due to ectopic Müllerian embryogenesis. Here, we present a case of a 21-year-old woman with a Clear Cell Carcinoma, Müllerian type, arising from the renal pelvis. Histologically, it consisted of tubulopapillary architecture with associated foamy macrophages and a mucinous background. The neoplastic cells exhibited variably sized round nuclei with prominent nucleoli, eosinophilic to vacuolated cytoplasm with occasional intracytoplasmic mucin vacuoles, and a hobnail appearance. Immunohistochemical stains showed that the neoplastic cells were positive for Pax-8, p53, CK7, HMWK 903, and INI-1 and focally positive for p504s (AMACR). The neoplastic cells were negative for GATA-3, CK5/CK6, p63, CK20, and CDX-2 immunostains, ruling out urothelial or enteric phenotype. Additional immunostains performed by an outside institution showed that the neoplastic cells were positive for HNF-1β. The overall morphology and immunophenotype were consistent with Clear Cell Carcinoma of Müllerian origin arising from the renal pelvis. Follow-up revealed no metastasis or other tumor sites, supporting that this was the primary location.

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

Hyalinizing clear cell carcinoma of the nasopharynx operated by trans-oral and trans-palatal approach

2015 ◽  
Vol 129 (S2) ◽  
pp. S95-S97 ◽  
Author(s):  
T Nakashima ◽  
R Yasumatsu ◽  
M Yamauchi ◽  
S Toh ◽  
T Nakano ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Good Prognosis ◽  
Salivary Gland Neoplasm ◽  
Hyalinizing Clear Cell Carcinoma

AbstractBackground:Hyalinizing clear cell carcinoma is a rare minor salivary gland neoplasm. The treatment of choice is surgical resection with or without post-operative radiotherapy. This tumour often demonstrates a good prognosis.Case report:We report a case of hyalinizing clear cell carcinoma arising in the nasopharynx. A 27-year-old female presented with progressive hearing disturbance and tinnitus. On examination, an expansile mass was observed in her nasopharynx. Biopsy was performed and the pathology results returned as clear cell carcinoma.Results and conclusion:Surgical resection was performed trans-orally accompanied by trans-palatal approach. She has no recurrence during more than two years of follow up.

Renal Clear Cell Carcinoma Appearing as a Left Neck Mass

1996 ◽  
Vol 75 (9) ◽  
pp. 620-622 ◽  
Author(s):  
Michael A. Boggess ◽  
T. Oma Hester ◽  
Sanford M. Archer
Keyword(s):  
Cell Carcinoma ◽  
Head And Neck ◽  
Soft Tissues ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Neck Mass ◽  
Renal Clear Cell Carcinoma ◽  
Primary Tumors ◽  
Left Neck

Malignant clear cell tumors of the head and neck are uncommon. Primary tumors may arise from the salivary glands, thyroid gland, or parathyroid glands, while metastatic tumors most commonly arise from the lungs, kidneys, and female genital tract. Renal cell carcinoma is the third most common metastatic tumor to the bone and soft tissues of the head and neck. Despite this, there have been few reported cases of renal clear cell carcinoma metastases to the neck. Here we report a unique case of an otherwise asymptomatic young woman with a left neck mass as the first clinical sign of advanced renal clear cell carcinoma.

scholarly journals An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Goran Gudelj ◽  
Tena Simunjak ◽  
Marica Zizic ◽  
Boris Simunjak ◽  
Martin Jurlina
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Tumor Location ◽  
Total Recovery ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Left Posterior

Abstract Hyalinizing clear cell carcinoma (HCCC) is a rare, predominantly minor salivary gland tumor. Most of these tumors occur in the oral cavity, mainly the palate and tongue. Primary localization of the tumor in the region of the nasal cavity and paranasal sinuses is extremely rare and, with only a few cases reported in the literature so far. We present an extremely rare case of a 61-year-old woman with hyalinizing clear cell carcinoma (HCCC), occupying the left posterior nasal and nasopharyngeal cavity, as a primary tumor location. The patient total recovery was uneventful, and she is now free of disease at three years postoperative follow-up.

Nine Years of Follow-Up of a Patient with Thyroid Metastasis from Clear Cell Carcinoma: A Case Report

2011 ◽  
pp. P3-646-P3-646
Author(s):  
Jordana B Daltrozo ◽  
Camila G Pereira ◽  
Marcelo F Ronsoni ◽  
Marisa H Coral ◽  
Alexandre Hohl
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Thyroid Metastasis

Neoadjuvant Chemotherapy Followed by Cesarean Radical Hysterectomy in a Triplet Pregnancy Complicated by Clear Cell Carcinoma of the Cervix: A Case Presentation and Literature Review

2012 ◽  
Vol 22 (7) ◽  
pp. 1198-1202 ◽  
Author(s):  
Ali Ayhan ◽  
Polat Dursun ◽  
Burcu Kisa Karakaya ◽  
Ozlem Ozen ◽  
Cagla Tarhan
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Radical Hysterectomy ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Term Pregnancy ◽  
Triplet Pregnancy

ObjectiveTo report a triplet pregnancy complicated by clear cell cervical carcinoma that was managed using neoadjuvant chemotherapy followed by caesarean radical hysterectomy.Patient HistoryA 26-year-old woman had a diagnosis of cervical clear cell carcinoma, which was International Federation of Gynecology and Obstetrics stage IB1, at 18 weeks of gestation during a triplet pregnancy. Owing to the patient’s strong desire for full-term pregnancy, 3 cycles of neoadjuvant chemotherapy was administered after magnetic resonance imaging evaluation of the tumor. The patient underwent cesarean delivery and radical hysterectomy at gestational week 32. The hysterectomy specimen revealed stage IB1 clear cell adenocarcinoma of the cervix. The neonates and the mother did not have any complications related to the treatment during 36 months of follow-up.ConclusionTo the best of our knowledge, this is the first report of a triplet pregnancy complicated by cervical clear cell carcinoma that was successfully treated with neoadjuvant chemotherapy and cesarean radical hysterectomy. Our experience and literature review suggest that neoadjuvant chemotherapy for cervical carcinoma diagnosed during pregnancy is associated with excellent oncologic and fetal outcome; therefore, it may be considered as a temporary fertility-sparing approach in selected patients with a strong desire for full-term pregnancy. Nonetheless, additional research and long-term follow-up are needed to reach a more definitive conclusion.

Low expression of gamma-glutamyl transpeptidase 1 is an independent poor prognostic factor in ovarian clear cell carcinoma, in relation to up-regulation of immune suppressive genes and EMT-related genes.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 6042-6042
Author(s):  
Hiroshi Asano ◽  
Ryosuke Matsuoka ◽  
Kanako C Hatanaka ◽  
Daisuke Endo ◽  
Ayako Nozaki ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ovarian Clear Cell Carcinoma ◽  
Poor Prognostic Factor ◽  
Gsh Metabolism ◽  
Low Expression

6042 Background: Ovarian clear cell carcinoma (OCCC) is a distinct entity from other epithelial ovarian cancers such as the most prevalent high-grade serous cancer (HGSC), and often exhibit less sensitivity to platinum-based chemotherapy. Several studies using cell lines have reported that glutathione (GSH) metabolism plays an important role in chemo-resistance of OCCC. Here, we aimed to correlate the prognosis of OCCC and the expression of gamma-glutamyltransferase 1 (GGT1), one of the key enzymes in GSH metabolism. Methods: We prepared a FFPE-tissue microarray, and analyzed 56 OCCC patients with the follow-up periods over 3 years. Expression level of GGT1 was evaluated by immunohistochemistry (IHC) using H-score (0-300), and was correlated with clinical outcomes. The prognostic significance was assessed by multivariate analysis using Cox regression model. To investigate the possible related pathways, we performed transcriptome analysis using Ion AmpliSeq Transcriptome Human Gene Expression Kit (Thermo Fisher Scientific) from the frozen tissue specimens collected from 33 ovarian cancer patients including 15 OCCC patients and 18 HGSC patients. Results: The OCCC patients were divided into two populations in the histogram of H-score in IHC staining, and the cut-off value was 90; 44 cases showed GGT1-high, and remaining 12 cases were GGT1-low. Follow-up periods, FIGO stage, and optimal surgery rate were not significantly different between two groups. However, platinum-resistant recurrent rate was significantly higher (42% vs. 14%, p=0.027), and overall survival (OS) was significantly shorter (5-year OS; 42% vs. 72%, p=0.0226) in GGT1-low OCCC. Multivariate analysis revealed that low expression of GGT1 was one of the independent poor prognostic factors as well as platinum-drug resistance. In enrichment analysis, the genes related to GSH metabolism, such as SLC3A1, GGT1, CSE, and GPX3 were up-regulated and positively correlated with HNF1B expression in OCCC. The expression level of GGT1 was inversely correlated with that of immune suppressive genes (TGF-b, IFNG, IL10, FOXP3, PD-L1, CTLA4) and epithelial-mesenchymal transition (EMT)-related genes (CDH2, VIM, TWIST1, ZEB1, ZEB2) in OCCC samples. Conclusions: Low expression of GGT1 is an independent poor prognostic factor probably in part due to suppression of tumor immunity and induction of EMT in OCCC.

Cytologic Features of Clear Cell Carcinoma of the Female Genital Tract

2004 ◽  
Vol 48 (1) ◽  
pp. 47-51 ◽  
Author(s):  
José A. Jiménez-Heffernan ◽  
Blanca Vicandi ◽  
Pilar González-Peramato ◽  
Ana Pérez-Campos ◽  
Pilar López-Ferrer ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Genital Tract ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Female Genital
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